The Korean Severe Asthma Registry (KoSAR): real world research in severe asthma

Kim, Sang‐Heon; Lee, Hyun; Park, Soyoung; Park, So Young; Song, Woo-Jung; Kim, Joohee; Park, Heung-Woo; Cho, You Sook; Yoon, Ho Joo

doi:10.3904/kjim.2021.403

Cited by 16 publications

(12 citation statements)

References 66 publications

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“…Cognitive debriefing verified that the Korean version of the questionnaire items were well understood and did not require further modification. Through these steps, a Korean version of the SAQ was generated to be used as an assessment tool for health-related QOL in further clinical studies of severe asthma patients in Korea ( 25 ).…”

Section: Discussionmentioning

confidence: 99%

Development and linguistic validation of the Korean version of the Severe Asthma Questionnaire

Kang¹,

Ahn²,

Lee³

et al. 2023

J Thorac Dis

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Background Severe asthma, compared with mild to moderate asthma, has a larger impact on the quality of life (QOL) of the affected patients and their families. These findings underscore the need for patient-reported outcomes that are specific to severe asthma. The Severe Asthma Questionnaire (SAQ) is a validated disease-specific questionnaire that addresses the impact of severe asthma on patients. The present study aimed to develop the Korean language version of the SAQ (SAQ-K), with the translation and linguistic validation. Methods The development of SAQ-K was achieved through a process of forward translation, reconciliation, back translation, reconciliation, cognitive debriefing involving severe asthmatics, proofreading, and the final report. Results Two medical personnel who were fluent in Korean and English independently translated the original English version of the SAQ into Korean. After incorporating these translations into a single reconciled version, two other bilingual personnel translated the Korean draft back into English. Discrepancies between the original form and the first Korean translation were then reviewed by the panel. The translated questionnaire was then tested in cognitive debriefing interviews with 15 severe asthma patients. Through this cognitive debriefing process, the second version was verified and finally proofread to check for spelling, grammar, layout, and formatting as the final version. Conclusions We have generated the SAQ-K to enable clinicians and researchers to assess the health status of severe asthma patients in Korea.

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Section: Discussionmentioning

confidence: 99%

Development and linguistic validation of the Korean version of the Severe Asthma Questionnaire

Kang¹,

Ahn²,

Lee³

et al. 2023

J Thorac Dis

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“…We used the Korean Severe Asthma Registry (KoSAR) for this study, which is the representative severe asthma registry in Korea established by the Working Group on Severe Asthma, the Korean Academy of Asthma, Allergy, and Clinical Immunology (KAAACI) in 2010. 16 17 18 Currently, 25 university hospitals are participating in the KoSAR. The registry is composed of adult patients (≥ 18 years) with severe asthma who have been treated by asthma specialists for at least one year.…”

Section: Methodsmentioning

confidence: 99%

Clinical Characteristics and Disease Burden of Severe Asthma According to Oral Corticosteroid Dependence: Real-World Assessment From the Korean Severe Asthma Registry (KoSAR)

Lee

Kim

Park

et al. 2022

Allergy Asthma Immunol Res

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Purpose Oral corticosteroids (OCS) are commonly used in patients with severe asthma, but they are associated with several adverse events. We estimated the prevalence of patients with OCS-dependent asthma in a large nationwide registry for severe asthma and delineated their clinical characteristics. Methods This cross-sectional study analyzed enrollment data of the patients recruited in the Korean Severe Asthma Registry (KoSAR) from 2010 to 2019. The clinical characteristics of patients were compared according to OCS dependency, which was defined as maintenance OCS treatment lasting at least 6 months during the 12 months prior to enrollment. Results Among the 562 patients with severe asthma, 121 (21.5%) patients were defined as having OCS-dependent asthma. Compared with the OCS-independent group, the OCS-dependent group was older at symptom onset and had a higher prevalence of anxiety, worse lung function, and used more medication than the control group. Despite the higher doses of daily ICS and 6-month cumulative OCS, the OCS-dependent group reported greater consumption of relievers and a higher prevalence of unscheduled emergency room visits and repeated OCS bursts. Although anti-interleukin-5 was more commonly prescribed for patients with OCS-dependent asthma, only a limited proportion of patients with severe asthma received biologics. Conclusions One-fifth of patients with severe asthma had OCS-dependency, which was associated with a greater disease burden compared to those with OCS-independent asthma. Active intervention including initiation of biologics and regular assessment of OCS-induced morbidities is warranted to reduce the use of OCS and its potential adverse effects.

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“…Large-scale patient registries may serve as databases. 65,71 In the Korean Severe Asthma Registry phase 2 (KoSAR-2) study, 97 we have added a module for systematic assessment of potentially treatable traits and expect to generate the data on major treatable traits in terms of the frequency and impact on longitudinal outcomes in Korean patients with severe asthma ( Table 2 ). Given the future potential risks of mortality and treatment-related morbidity, 47 long-term outcomes should be investigated in relation to specific traits and treatments.…”

Section: The Concept Of Treatable Traits In Severe Asthmamentioning

confidence: 99%

Evolving Concept of Severe Asthma: Transition From Diagnosis to Treatable Traits

Park

Kang

Song

et al. 2022

Allergy Asthma Immunol Res

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In recent decades, the concept of severe asthma has evolved from an umbrella term encompassing patients with high-intensity treatment needs to a clinical syndrome with heterogeneous, albeit distinct, pathophysiological processes. Biased and unbiased cluster approaches have been used to identify several clinical phenotypes. In parallel, cellular and molecular approaches allow for the development of biological therapies, especially targeting type 2 (T2) cytokine pathways. Although T2-biologics have significantly improved clinical outcomes for patients with severe asthma in real-world practice, questions on the proper use of biologics remain open. Furthermore, a subset of severe asthma patients remains poorly controlled. The unmet needs require a new approach. The “treatable traits” concept has been suggested to address a diversity of pathophysiological factors in severe asthma and overcome the limitations of existing treatment strategies. With a tailored therapy that targets the treatable traits in individual patients, better personalized medical care and outcomes should be achieved.

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The Korean Severe Asthma Registry (KoSAR): real world research in severe asthma

Cited by 16 publications

References 66 publications

Development and linguistic validation of the Korean version of the Severe Asthma Questionnaire

Development and linguistic validation of the Korean version of the Severe Asthma Questionnaire

Clinical Characteristics and Disease Burden of Severe Asthma According to Oral Corticosteroid Dependence: Real-World Assessment From the Korean Severe Asthma Registry (KoSAR)

Evolving Concept of Severe Asthma: Transition From Diagnosis to Treatable Traits

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