The known genetic loci for telomere length may be involved in the modification of telomeres length after birth

Weng, Qiao; Du, Jiangbo; Yu, Fei; Huang, Tingpei; Chen, Mengxi; Lv, Hong; Ma, Hongxia; Hu, Zhibin; Jin, Guangfu; Hu, Yali; Shen, Hongbing

doi:10.1038/srep38729

Cited by 18 publications

(17 citation statements)

References 40 publications

(52 reference statements)

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“…We also observed that during fetal development, telomere length improves in cord blood; thus, mothers had a shorter length than a cord in our study which has also been observed by Weng et al (p < 0.001) [50].…”

Section: Discussionsupporting

confidence: 90%

Telomere reprogramming during fetal life in low socioeconomic mothers

Farrukh

Baig

Hussain

et al. 2019

Egypt J Med Hum Genet

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Background: Relative telomere length (RTL), the biological chronometer, varies considerably among individuals under the influence of multiple risk factors such as socioeconomic status (SES). It is anticipated that during fetal life, telomeres undergo reprogramming. The purpose of this study is to find the association between SES and telomere length of mother-newborn and genetic remodeling that occurs during fetal life. Results: The mean telomere/single gene copy (T/S) ratio and RTL (base pairs) among 250 mother-newborn dyads were higher in cord blood of newborns (1.18 ± 0.23) (6765 ± 1350 bp) (95% confidence level) compared to maternal blood (1.13 ± 0.18) (6432 ± 1350 bp) of all SES of the Pakistani population. A positive association (r = 0.396, p < 0.05) (F (2,238) = 9.229, p < 0.05) was found between maternal and newborn telomere length by using Spearman's correlation and regression analyses. Calculated RTL by Kruskal Wallis was found significant in low SES maternal and cord blood (5916 ± 754-6214 ± 596) compared to high SES maternal and cord blood (6818 ± 1248-7471 ± 1851). Conclusion: Significantly longer RTL in cord blood than maternal blood was observed in the targeted Pakistani population, including the low socioeconomic group highlighting fetal telomere reprogramming. High education appears to have a strong determining factor for longer RTL.

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Section: Discussionsupporting

confidence: 90%

Telomere reprogramming during fetal life in low socioeconomic mothers

Farrukh

Baig

Hussain

et al. 2019

Egypt J Med Hum Genet

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“…Recent studies indicated that rs10936599 in TERC was associated with telomere length and with an increased risk of cancers, but the conclusions were inconsistent [ 20 , 25 , 26 ]. To date, there no report on the association between rs10936599 and lung cancer risk.…”

Section: Discussionmentioning

confidence: 99%

Genetic variations inTERCandTERTgenes are associated with lung cancer risk in a Chinese Han population

Tan²,

Meng

et al. 2017

Oncotarget

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The study was aimed to explore whether the TERT and TERC polymorphisms are associated with the lung cancer risk. Five TERC and TERT polymorphisms were genotyped from 554 lung cancer patients and 603 healthy controls. We used χ2 test, genetic model, linkage disequilibrium (LD) and haplotype analyses to evaluate the association between the polymorphisms and lung cancer risk. We found that the allele “C” of rs10936599 (TERC) and the allele “T” of rs10069690 (TERT) were associated with increased risk of lung cancer (OR = 1.32, 95% CI: 1.12-1.55, P = 0.001; OR = 1.41, 95% CI: 1.14-1.76, P = 0.002, respectively). The genotype of “CC” of rs10936599, genotype “CT” of rs10069690 and genotype “GG and “AG” of rs2853677 were also associated with increased the risk of lung cancer. In addition, rs10936599 under the dominant, recessive and log-additive models; rs10069690 under the dominant, overdominant and log-additive models; rs2853677 under the dominant and log-additive models were found to be associated with increased lung cancer risk. The SNP rs2242652 was found to be associated with an increased lung cancer risk under the dominant and overdominant models without adjustment. The haplotype “TA” of TERT was also associated with an increased risk of lung cancer. Our study indicated that rs10936599 (TERC) and rs10069690, rs2242652 and rs2853677 in TERT and haplotype “TA” of TERT were revealed as risk factors of lung cancer in a Chinese Han population. However, it required to verify our result and investigate the function genetic variants and mechanism of lung cancer.

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“…One of the possible reasons for this might be the heterogeneity between populations, as studies were performed in healthy African-American children and adolescents [57] and in a healthy European population [58]. Genotyping of the SNPs identified in the European cohort was also performed in newborns in an Asian population, but no significant association for any individual variant was detected [59].…”

Section: Genetic Determinants Of Tlmentioning

confidence: 99%

Telomere length determinants in childhood

Gorenjak

Petrelis

Stathopoulou

et al. 2019

Clinical Chemistry and Laboratory Medicine (CCLM)

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Telomere length (TL) is a dynamic marker that reflects genetic predispositions together with the environmental conditions of an individual. It is closely related to longevity and a number of pathological conditions. Even though the extent of telomere research in children is limited compared to that of adults, there have been a substantial number of studies providing first insights into child telomere biology and determinants. Recent discoveries revealed evidence that TL is, to a great extent, determined already in childhood and that environmental conditions in adulthood have less impact than first believed. Studies have demonstrated that large inter-individual differences in TL are present among newborns and are determined by diverse factors that influence intrauterine development. The first years of child growth are associated with high cellular turnover, which results in fast shortening of telomeres. The rate of telomere loss becomes stable in early adulthood. In this review article we summarise the existing knowledge on telomere dynamics during the first years of childhood, highlighting the conditions that affect newborn TL. We also warn about the knowledge gaps that should be filled to fully understand the regulation of telomeres, in order to implement them as biomarkers for use in diagnostics or treatment.

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The known genetic loci for telomere length may be involved in the modification of telomeres length after birth

Cited by 18 publications

References 40 publications

Telomere reprogramming during fetal life in low socioeconomic mothers

Telomere reprogramming during fetal life in low socioeconomic mothers

Genetic variations inTERCandTERTgenes are associated with lung cancer risk in a Chinese Han population

Telomere length determinants in childhood

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