The kisspeptin system genes in teleost fish, their structure and regulation, with particular attention to the situation in Pleuronectiformes

Mechaly, Alejandro S.; Viñas, Jordi; Piferrer, Francesc

doi:10.1016/j.ygcen.2013.04.010

Cited by 56 publications

(39 citation statements)

References 120 publications

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“…Kisspeptins regulate vertebrate reproduction by stimulating GnRH release [Elizur, 2009;Mechaly et al, 2013;Espigares et al, 2015] but may also mediate transitions in social status [Maruska and Fernald, 2011] via their receptors on AVT and IT neurons [Kanda et al, 2013]. IT, the teleost homologue of mammalian oxytocin, is also associated with social status and sex-specific reproductive behaviours [Goodson and Bass, 2000;Lema et al, 2015].…”

Section: Neuroendocrine Control Of Sex Changementioning

confidence: 99%

Bending Genders: The Biology of Natural Sex Change in Fish

Todd

Hui

Muncaster

et al. 2016

Sex Dev

117

126

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Sexual fate is no longer seen as an irreversible deterministic switch set during early embryonic development but as an ongoing battle for primacy between male and female developmental trajectories. That sexual fate is not final and must be actively maintained via continuous suppression of the opposing sexual network creates the potential for flexibility into adulthood. In many fishes, sexuality is not only extremely plastic, but sex change is a usual and adaptive part of the life cycle. Sequential hermaphrodites begin life as one sex, changing sometime later to the other, and include species capable of protandrous (male-to-female), protogynous (female-to-male), or serial (bidirectional) sex change. Natural sex change involves coordinated transformations across multiple biological systems, including behavioural, anatomical, neuroendocrine, and molecular axes. We here review the biological processes underlying this amazing transformation, focussing particularly on its molecular basis, which remains poorly understood, but where new genomic technologies are significantly advancing our understanding of how sex change is initiated and progressed at the molecular level. Knowledge of how a usually committed developmental process remains plastic in sequentially hermaphroditic fishes is relevant to understanding the evolution and functioning of sexual developmental systems in vertebrates generally, as well as pathologies of sexual development in humans.

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Section: Neuroendocrine Control Of Sex Changementioning

confidence: 99%

Bending Genders: The Biology of Natural Sex Change in Fish

Todd

Hui

Muncaster

et al. 2016

Sex Dev

117

126

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“…The neuropeptides kisspeptin (Kiss1 and Kiss2) and gonadotropin-inhibitory-hormone (GnIH) are key regulators of the HPG axis, but their roles in sex change are not yet well studied. Kisspeptin stimulates the expression and secretion of GnRH in the hypothalamic preoptic area of fish (reviewed by Zohar et al, 2010;Mechaly et al, 2013); conversely, GnIH inhibits GnRH and LH release in birds (reviewed by Ubuka et al, 2012Ubuka et al, , 2014 and was reported to reduce serum LH levels in goldfishÀ Àalthough with complicated and stage-dependent effects on gonadotropin synthesis and release (Moussavi et al, 2012(Moussavi et al, , 2013Qi et al, 2013). Opposing expression patterns of kiss2 (Shi et al, 2010) and gnih (Wang et al, 2015) were consistently observed in the hypothalamus of protogynous groupers following 17a-methyltestosterone-induced sex change.…”

Section: Hypothalamic Neuropeptides and Monoaminesmentioning

confidence: 99%

“…For protogynous groupers, 12 hr after injection of GnIH, hypothalamic gnrh1 expression # while gnrh3 "; pituitary lhb expression # while fshb expression was not affected except for GnIH-I treated group (Wang et al, 2015). The functions of teleost orthologs of GnIH remain inconclusive (reviewed by (Ogawa and Parhar, 2014) Kisspeptin (Kiss1/2) Bluehead wrasse: Presumably stimulatory, but kiss2 implantation was not sufficient to induce sex change in females in the presence of TP males (Lamm et al, 2015, unpublished Zohar et al, 2010;Mechaly et al, 2013). Within 6 hr after intraperitoneal Kiss2 injection in mature females of protogynous groupers, hypothalamic gnrh1 and pituitary fshb expression significantly ", while hypothalamic gnrh3…”

Section: Orange-spotted Grouper (Epinephelus Coioides)mentioning

confidence: 99%

Sexual plasticity: A fishy tale

Liu

Todd

Lokman

et al. 2016

Molecular Reproduction Devel

122

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SUMMARYTeleost fish exhibit remarkably diverse and plastic patterns of sexual development. One of the most fascinating modes of plasticity is functional sex change, which is widespread in marine fish including species of commercial importance; however, the regulatory mechanisms remain elusive. In this review, we explore such sexual plasticity in fish, using the bluehead wrasse (Thalassoma bifasciatum) as the primary model. Synthesizing current knowledge, we propose that cortisol and key neurochemicals modulate gonadotropin releasing hormone and luteinizing hormone signaling to promote socially controlled sex change in protogynous fish. Future largescale genomic analyses and systematic comparisons among species, combined with manipulation studies, will likely uncover the common and unique pathways governing this astonishing transformation. Revealing the molecular and neuroendocrine mechanisms underlying sex change in fish will greatly enhance our understanding of vertebrate sex determination and differentiation as well as phenotypic plasticity in response to environmental influences.

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“…[121][122][123][124][125][126][127][128][129][130][131][132] Similar sex difference in most other vertebrates studied to date, including frogs, lizards, birds, and mammals; too numerous to list here but reviewed elsewhere. [138][139][140][141][142] Estrogen receptor Females have more estrogen binding (or, in later studies, more estrogen receptor alpha protein or mRNA) in the POA than do males. 135 Testosterone acts perinatally after conversion to an estrogen; cell death does not seem to be involved in establishing the sex difference.…”

Section: Vasopressin Expressionmentioning

confidence: 90%