The Kinetics of Thermal Injury in Human Renal Carcinoma Cells

He, Xiaoming; Bischof, John C.

doi:10.1007/s10439-005-2508-1

Cited by 58 publications

(50 citation statements)

References 38 publications

(52 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For a specified exposure temperature and time, the Arrhenius fit parameters determine the probability of cell damage. Arrhenius parameters have been determined in several body tissues, including the liver at high temperatures [31][32][33]38]. In the majority of studies, temperature and tissue injury profiles are calculated sequentially, meaning that Arrhenius calculations are not made until temperature calculations are completed [29][30].…”

Section: Introductionmentioning

confidence: 99%

Considerations for Thermal Injury Analysis for RF Ablation Devices

Chang¹

2010

TOBEJ

View full text Add to dashboard Cite

Abstract:Background: The estimation of lesion size is an integral part of treatment planning for the clinical applications of radiofrequency ablation. However, to date, studies have not directly evaluated the impact of different computational estimation techniques for predicting lesion size. In this study, we focus on three common methods used for predicting tissue injury: (1) iso-temperature contours, (2) Cumulative equivalent minutes, (3) Arrhenius based thermal injury. Methods:We created a geometric model of a multi-tyne ablation electrode and simulated thermal and tissue injury profiles that result from three calculation methods after 15 minutes exposure to a constant RF voltage source. A hybrid finite element technique was used to calculate temperature and tissue injury. Time-temperature curves were used in the assessment of iso-temperature thresholds and the method of cumulative equivalent minutes. An Arrhenius-based formulation was used to calculate sequential and recursive thermal injury to tissues. Results: The data demonstrate that while iso-temperature and cumulative equivalent minute contours are similar in shape, these two methodologies grossly over-estimate the amount of tissue injury when compared to recursive thermal injury calculations, which have previously been shown to correlate closely with in vitro pathologic lesion volume measurement. In addition, Arrhenius calculations that do not use a recursive algorithm result in a significant underestimation of lesion volume. The data also demonstrate that lesion width and depth are inadequate means of characterizing treatment volume for multi-tine ablation devices. Conclusions: Recursive thermal injury remains the most physiologically relevant means of computationally estimating lesion size for hepatic tumor applications. Iso-thermal and cumulative equivalent minute approaches may produce significant errors in the estimation of lesion size.

show abstract

Section: Introductionmentioning

confidence: 99%

Considerations for Thermal Injury Analysis for RF Ablation Devices

Chang¹

2010

TOBEJ

View full text Add to dashboard Cite

show abstract

“…The fitting was done with a non-linear optimization procedure (the flexible tolerance method 28 ) to minimize the root mean square between the model predictions and the experimental data, which has been used by the authors in a number of studies to extract multiple parameters in a variety of models for various applications. 22,23,25,26 …”

Section: Determination Of Model Parametersmentioning

confidence: 98%

Biotransport Phenomena in Freezing Mammalian Oocytes

Yang

Veres²,

Szalai³

et al. 2010

Ann Biomed Eng

Self Cite

View full text Add to dashboard Cite

Water transport across the cell plasma membrane and intracellular ice formation (IIF)-the two biophysical events that may cause cell injury during cryopreservation-were studied by cryomicroscopy and modeling using mammalian (Peromyscus) oocytes. Unusually high activation energy for water transport across the cell plasma membrane was identified indicating that the water transport process is unusually sensitive to temperature (and cooling rate). Although literally all studies on IIF were conducted using protocols with ice-seeding (seeding extracellular ice usually at ≥-7 °C), it is not used for cell cryopreservation by vitrification that is becoming increasingly popular today. In this article, we show that ice-seeding has a significant impact on IIF. With ice-seeding and cooling at 60 °C/min, IIF was observed to occur over a wide range from approximately -8 to -48 °C with a clear change of the ice nucleation mechanism (from surface- to volume-catalyzed nucleation) at approximately -43 °C. On the contrary, without ice-seeding, IIF occurred over a much narrower range from approximately -19 to -27 °C without a noticeable change of the nucleation mechanism. Moreover, the kinetics of IIF without ice-seeding was found to be strongly temperature (and cooling rate) dependent. These findings indicate the importance of quantifying the IIF kinetics in the absence of ice-seeding during cooling for development of optimal vitrification protocols of cell cryopreservation.

show abstract

“…The mathematical relationship between ΔE c and A c was summarized by He and Bischof et al [21,23] as…”

Section: S831mentioning

confidence: 99%

A three-dimensional model and numerical simulation regarding thermoseed mediated magnetic induction therapy conformal hyperthermia

Wang¹,

Wu²,

Zhuo³

et al. 2016

THC

View full text Add to dashboard Cite

Abstract. In order to ensure the safety and effectiveness of magnetic induction hyperthermia in clinical applications, numerical simulations on the temperature distributions and extent of thermal damage to the targeted regions must be conducted in the preoperative treatment planning system. In this paper, three models, including a thermoseed thermogenesis model, tissue heat transfer model, and tissue thermal damage model, were established based on the four-dimensional energy field, temperature field, and thermal damage field distributions exhibited during hyperthermia. In addition, a numerical simulation study was conducted using the Finite Volume Method (FVM), and the accuracy and reliability of the magnetic induction hyperthermia model and its numerical calculations were verified using computer simulations and experimental results. Thus, this study promoted the application of computing methods to magnetic induction therapy and conformal hyperthermia, and improved the accuracy of the temperature field and tissue thermal damage distribution predictions.

show abstract

The Kinetics of Thermal Injury in Human Renal Carcinoma Cells

Cited by 58 publications

References 38 publications

Considerations for Thermal Injury Analysis for RF Ablation Devices

Considerations for Thermal Injury Analysis for RF Ablation Devices

Biotransport Phenomena in Freezing Mammalian Oocytes

A three-dimensional model and numerical simulation regarding thermoseed mediated magnetic induction therapy conformal hyperthermia

Contact Info

Product

Resources

About