The kinetics of the hydrolysis of procaine

Impact of Counterion on the Chemical Stability of Crystalline Salts of Procaine

“…In solution, procaine undergoes a pH‐dependent hydrolysis of the ester linkage to yield diethylaminoethanol and para ‐aminobenzoic acid ( p ‐aba) (Fig. 1), with specific acid and base catalysis 33, 34…”

Professor Akira Tsuji: Scientist, Educator, and Leader

“…A method of estimation of 6‐alpha‐glucosylglucogen and gentiobiose formed from glucose” in 1950, in Japanese; this was the first paper reporting the results of chemical kinetics 1. Coincidentally, Professor Takeru Higuchi, the father of modern day pharmaceutics in the United States, also published a paper entitled “The kinetics of the hydrolysis of procaine” in the same year 2. Akira Tsuji enjoyed both mathematics and physical chemistry, and thanks to the inspiring lectures of Professor Yamana, he became very interested in the study of chemical kinetics as a basis for understanding drug stability in solution.…”

A Kinetic Study of the Specific Hydrogen Ion Catalyzed Solvolysis of Chloramphenicol in Water-Propylene Glycol Systems**College of Pharmacy, Rutgers University, Newark 4, N. J.

“…The data obtained were analyzed with a view toward determining, if possible, the degrees of both hydrolytic and non-hydrolytic solvolysis (Figs. 1 and 2 ) as well as the influence of any electrostatic effects. …”