The kinetics of solubilisate exchange between water droplets of a water-in-oil microemulsion

Fletcher, Paul D. I.; Howe, Andrew M.; Robinson, Brian H.

doi:10.1039/f19878300985

Cited by 494 publications

(528 citation statements)

References 11 publications

Supporting

Mentioning

474

Contrasting

Unclassified

Order By: Relevance

“…The droplets are sequestered from each other by the solvent and the only communication between two water droplets is through the formation of transient reverse micelle dimers. 38 Intermicellar solute exchange can occur in these transient dimers. 39 However, the rate of exchange of large molecules, such as proteins, is dramatically slower than the rate of exchange of small molecules and salts.…”

Section: Two-step Condensation Methodsmentioning

confidence: 99%

A novel N-acyl phosphatidylethanolamine-containing delivery vehicle for spermine-condensed plasmid DNA

Shangguan¹,

Cabral-Lilly²,

Purandare³

et al. 2000

Gene Ther

View full text Add to dashboard Cite

A unique method for formulation of plasmid DNA with phospholipids has been devised for the purpose of producing vehicles that can mediate gene delivery and transfection of living cells. The polycation, spermine, was used to condense plasmid DNA within a water-in-chloroform emulsion stabilized by phospholipids. After organic solvent removal, the particles formed could be extruded to a number average size of about 200 nm and retained DNA that was protected from nuclease digestion. This resulted in a relatively high protected DNA-to-lipid ratio of approximately 1 g DNA/ mol lipid. The size distribution of the preparation was relatively homogeneous as judged by light microscopy and quasi-elastic light scattering. Electron microscopic studies showed structural heterogeneity, but suggested that at least some of the plasmid DNA in this preparation was in the form of the previously observed spermine-condensed bent rods and toroids and was encapsulated within liposomal membranes.

show abstract

Section: Two-step Condensation Methodsmentioning

confidence: 99%

A novel N-acyl phosphatidylethanolamine-containing delivery vehicle for spermine-condensed plasmid DNA

Shangguan¹,

Cabral-Lilly²,

Purandare³

et al. 2000

Gene Ther

View full text Add to dashboard Cite

show abstract

“…In water-in-oil microemulsions, the aqueous droplets continuously collide, coalesce and break apart resulting in a continuous exchange of solute content [32,56]. The collision process depends upon the diffusion of the aqueous droplets in the continuous media, i.e.…”

Section: Reactions In Microemulsionsmentioning

confidence: 99%

“…The collision process depends upon the diffusion of the aqueous droplets in the continuous media, i.e. oil, while the exchange process depends on the attractive interactions between the surfactant tails and the rigidity of the interface, as the aqueous droplets approach close to each other [32].…”

Section: Reactions In Microemulsionsmentioning

confidence: 99%

See 1 more Smart Citation

Preparation of nanoparticles of silver halides, superconductors and magnetic materials using water-in-oil microemulsions as nano-reactors

Pillai

Kumar

Hou

et al. 1995

Advances in Colloid and Interface Science

249

121

View full text Add to dashboard Cite

“…[116] Fletcher et al also provided a detailed investigation of the temperature, oil solvents and additives on the exchange kinetics in AOT systems. [117] By the superb advantages of such interfacial film of surfactants to split the confined nanoreactors of the encompassing solution as well as its ability for exchanging material, microemulsions (typically 1-50 nm in diameter) [118] can serve as a proper asset to stabilize the entire solution [119] and offer excellent control over shape, size and phase of the produced nanoparticles. [57] Synthesis of MNPs under microemulsion process entails simple stages as follows:…”

Section: Reverse Micelle (Microemulsion)mentioning

confidence: 99%

Synthesis, Functionalization, and Design of Magnetic Nanoparticles for Theranostic Applications

Mosayebi

Kiyasatfar

Laurent

2017

Adv Healthcare Materials

193

171

View full text Add to dashboard Cite

In order to translate nanotechnology into medical practice, magnetic nanoparticles (MNPs) have been presented as a class of non‐invasive nanomaterials for numerous biomedical applications. In particular, MNPs have opened a door for simultaneous diagnosis and brisk treatment of diseases in the form of theranostic agents. This review highlights the recent advances in preparation and utilization of MNPs from the synthesis and functionalization steps to the final design consideration in evading the body immune system for therapeutic and diagnostic applications with addressing the most recent examples of the literature in each section. This study provides a conceptual framework of a wide range of synthetic routes classified mainly as wet chemistry, state‐of‐the‐art microfluidic reactors, and biogenic routes, along with the most popular coating materials to stabilize resultant MNPs. Additionally, key aspects of prolonging the half‐life of MNPs via overcoming the sequential biological barriers are covered through unraveling the biophysical interactions at the bio–nano interface and giving a set of criteria to efficiently modulate MNPs' physicochemical properties. Furthermore, concepts of passive and active targeting for successful cell internalization, by respectively exploiting the unique properties of cancers and novel targeting ligands are described in detail. Finally, this study extensively covers the recent developments in magnetic drug targeting and hyperthermia as therapeutic applications of MNPs. In addition, multi‐modal imaging via fusion of magnetic resonance imaging, and also innovative magnetic particle imaging with other imaging techniques for early diagnosis of diseases are extensively provided.

show abstract

The kinetics of solubilisate exchange between water droplets of a water-in-oil microemulsion

Cited by 494 publications

References 11 publications

A novel N-acyl phosphatidylethanolamine-containing delivery vehicle for spermine-condensed plasmid DNA

A novel N-acyl phosphatidylethanolamine-containing delivery vehicle for spermine-condensed plasmid DNA

Preparation of nanoparticles of silver halides, superconductors and magnetic materials using water-in-oil microemulsions as nano-reactors

Synthesis, Functionalization, and Design of Magnetic Nanoparticles for Theranostic Applications

Contact Info

Product

Resources

About