The kinetics of reversal of pre‐sickled erythrocytes by the aqueous extract of<i> Cajanus cajan</i> seeds

Onah, Johnson Ogoda; Akubue, P. I.; Okide, George B.

doi:10.1002/ptr.1026

Cited by 29 publications

(10 citation statements)

References 11 publications

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“…Antisickling action of many plants of medicinal value and other naturally existing compounds may be attributed to the presence of amino acids [ 88 ]. Phenylalanine present in an herbal plant Cajanuscajan, and hydroxybenzoic acid present in another medicinal plant of the Vitex family are thought to be the reason for their antisickling effect [ 89 ]. Amino acids display their antisickling behavior by increasing the cell volume of the RBC’s, thereby decreasing the concentration of intracellular hemoglobin below the gelling threshold [ 90 ].…”

Section: Introductionmentioning

confidence: 99%

Precipitating factors and targeted therapies in combating the perils of sickle cell disease--- A special nutritional consideration

et al. 2016

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Nutritional research in sickle cell disease has been the focus in recent times owing to not only specific nutritional deficiencies, but also the improvements associated with less painful episodes. Though hydroxyurea remains the drug of choice, certain adverse health effects on long term supplementation makes room for researches of different compounds. Macro and micro nutrient deficiencies, along with vitamins, play an important role in not only meeting the calorific needs, but also reducing clinical complications and growth abnormalities. Symptoms of hyper protein metabolism, increased cell turnover, increased cardiac output, and appetite suppression due to enhanced cytokine production, might give us leads for better understanding of the mechanisms involved. Different nutritional approaches comprising of traditional herbal therapies, antioxidants, flavonoids, vitamins, minerals etc., reducing oxidative stress and blood aggregation, have been tried out to increase the health potential. Nutritional therapies may also serve complementary to the newer therapies using ozone, hematopoietic stem cell transplantation, antifungal medications, erythropoietin etc. Herein we try to present a holistic picture of the different patho-physiological mechanisms, and nutritional strategies adopted.

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Section: Introductionmentioning

confidence: 99%

Precipitating factors and targeted therapies in combating the perils of sickle cell disease--- A special nutritional consideration

et al. 2016

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“…The kinetics of reversal of presickled erythrocytes by aqueous extract of C. cajan seeds was reported [47] as well as the antisickling properties of Parquetina nigrescens and a Nigerian herbal formula, Ajawaron HF, using the method of sodium metabisulphite-inhibition of sickling for the analysis [26, 48]. …”

Section: Antisickling Agentsmentioning

confidence: 99%

“…A herbal preparation of Cajanus cajan was found to contain phenylalanine, carjaminose, and hydroxybenzoic acid as active constituents and are thought to be the reason for its antisickling effect [47]. Folk medicine reportedly uses Parquetina nigrescens L. (Asclepiadaceae) as a herbal remedy for the management of sickle cell anemia.…”

Section: Current Trends In Alternative Herbal Treatment Of Sickle mentioning

confidence: 99%

Phytomedicines and Nutraceuticals: Alternative Therapeutics for Sickle Cell Anemia

Imaga

2013

The Scientific World Journal

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Sickle cell anemia is a genetically inherited disease in which the “SS” individual possesses an abnormal beta globin gene. A single base substitution in the gene encoding the human β-globin subunit results in replacement of β6 glutamic acid by valine, leading to the devastating clinical manifestations of sickle cell disease. This substitution causes drastic reduction in the solubility of sickle cell hemoglobin (HbS) when deoxygenated. Under these conditions, the HbS molecules polymerize to form long crystalline intracellular mass of fibers which are responsible for the deformation of the biconcave disc shaped erythrocyte into a sickle shape. First-line clinical management of sickle cell anemia include, use of hydroxyurea, folic acid, amino acids supplementation, penicillinprophylaxis, and antimalarial prophylaxis to manage the condition and blood transfusions to stabilize the patient's hemoglobin level. These are quite expensive and have attendant risk factors. However, a bright ray of hope involving research into antisickling properties of medicinal plants has been rewarding. This alternative therapy using phytomedicines has proven to not only reduce crisis but also reverse sickling (in vitro). The immense benefits of phytomedicines and nutraceuticals used in the management of sickle cell anemia are discussed in this paper.

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“…ABC transporters play a crucial role in the growth and development of plants by detoxifying exogenous toxins in response to abiotic stress, and transporting metabolites including intercellular peptides, sugars, lipids, alkaloids, inorganic ions and other metabolic substances (Mendez & Salas, 2001;Morris & Zhang, of the pigeon pea play an important role in the adaptation of the plant to its adverse environment (Shepherd & Bhardwaj, 1986). It also possesses medicinal properties and is used widely in the chemical industry (Ogoda, Akubue & Okide, 2002;Pandey & Pandey, 1991).…”

Section: Introductionmentioning

confidence: 99%

The functional analysis of ABCG transporters in the adaptation of pigeon pea (Cajanus cajan) to abiotic stresses

Niu

Song

et al. 2021

PeerJ

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ATP-binding cassette (ABC) transporters are a class of proteins found in living organisms that mediate transmembrane transport by hydrolyzing ATP. They play a vital role in the physiological processes of growth and development in plants. The most numerous sub-type transporter in the ABC transporter family is the ABCG group and which have the most complex function in a plant’s response to abiotic stresses. Our study focused on the effect of ABCG transporters in the adaptation of the pigeon pea to adverse environments (such as drought, salt, temperature, etc.). We conducted a functional analysis of ABCG transporters in the pigeon pea and their role in response to abiotic stresses. A total of 51 ABCG genes (CcABCGs) were identified, and phylogenetic analysis was conducted. We also identified the physicochemical properties of the encoded proteins, predicted their subcellular localization, and identified of the conserved domains. Expression analysis showed that ABCG genes have different expression profiles with tissues and abiotic stresses. Our results showed that CcABCG28 was up-regulated at low temperatures, and CcABCG7 was up-regulated with drought and aluminum stress. The initial results revealed that ABCG transporters are more effective in the abiotic stress resistance of pigeon peas, which improves our understanding of their application in abiotic stress resistance.

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The kinetics of reversal of pre‐sickled erythrocytes by the aqueous extract of Cajanus cajan seeds

Cited by 29 publications

References 11 publications

Precipitating factors and targeted therapies in combating the perils of sickle cell disease--- A special nutritional consideration

Precipitating factors and targeted therapies in combating the perils of sickle cell disease--- A special nutritional consideration

Phytomedicines and Nutraceuticals: Alternative Therapeutics for Sickle Cell Anemia

The functional analysis of ABCG transporters in the adaptation of pigeon pea (Cajanus cajan) to abiotic stresses

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