The Kinetics of Intravenously Administered Methyl Mercury in Man

Smith, J. C.; Allen, Patrick; Turner, Michael D.; Most, Bernard M.; Fisher, Henry L.; Hall, Larry L.

doi:10.1006/taap.1994.1204

Cited by 104 publications

(61 citation statements)

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“…10 ~ 15 μg/dl as the background level (Mahaffey et al, 1982), may be cited. Most human studies using an isotope-labeled metal (Aberg et al, 1969;Miettinen et al, 1971;Smith et al, 1994) ignored the background levels or did not exactly present them. Rather, the above formula initially must have been practical in light of the background uncertainties (Rabinowitz et al, 1976).…”

Section: Discussionmentioning

confidence: 99%

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Hair-to-blood ratio and biological half-life of mercury: experimental study of methylmercury exposure through fish consumption in humans

et al. 2012

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Section: Discussionmentioning

confidence: 99%

“…Some experimental studies of the MeHg kinetics in humans were conducted several decades ago (Aberg et al, 1969;Birke et al, 1972;Hislop et al, 1983;Kershaw et al, 1980;Miettinen et al, 1971;Sherlock et al, 1984;Smith et al, 1994). The exposure settings of those studies may differ from our current state in general, i.e.…”

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confidence: 99%

Hair-to-blood ratio and biological half-life of mercury: experimental study of methylmercury exposure through fish consumption in humans

et al. 2012

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“…Refering to the scientific literature devoted to the pharmacokinetics of MeHg in the human body (see Rahola et al [1972], Smith et al [1994], Smith and Farris [1996], IPCS [1987]), the biological half-life fluctuates at around 44 days. This numerical value, converted in hours, is thus retained for performing simulations, leading to pick log 2/(44 × 24) for the acceleration parameter estimateθ.…”

Section: Contamination Data Cmentioning

confidence: 99%

Statistical analysis of a dynamic model for dietary contaminant exposure

Bertail

Clémençon

Tressou

2009

Journal of Biological Dynamics

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This paper is devoted to the statistical analysis of a stochastic model introduced in Bertail, Clémençon & Tressou (2008) for describing the phenomenon of exposure to a certain food contaminant. In this modeling, the temporal evolution of the contamination exposure is entirely determined by the accumulation phenomenon due to successive dietary intakes and the pharmacokinetics governing the elimination process in between intakes, in such a way that the exposure dynamic through time is described as a piecewise deterministic Markov process. Paths of the contamination exposure process are scarcely observable in practice, therefore intensive computer simulation methods are crucial for estimating the timedependent or steady-state features of the process. Here we consider simulation estimators based on consumption and contamination data and investigate how to construct accurate bootstrap confidence intervals for certain quantities of considerable importance from the epidemiology viewpoint. Special attention is also paid to the problem of computing the probability of certain rare events related to the exposure process path arising in dietary risk analysis using multilevel splitting or importance sampling techniques. Applications of these statistical methods to a collection of datasets related to dietary methyl mercury contamination are discussed thoroughly.

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“…The movement of Hg through the system was based on studies that examined the relationship between intake and blood MeHg (Sherlock et al 1984), blood MeHg and hair total Hg (THg) , and blood MeHg and fetal blood MeHg (Stern and Smith 2003). Studies examining the rates of excretion of Hg and the ratio between blood and tissue MeHg were also used to increase the accuracy of the simulation (Smith et al 1994;Cernichiari et al 2007;Clarkson et al 2007). …”

Section: Introductionmentioning

confidence: 99%

Analysis of potential mercury policies: The impact of stream basin characteristics on susceptible populations

Chan

Jacobs

2012

Integr Envir Assess & Manag

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Human exposure to Hg through fish consumption from local waterways is an ongoing concern to regulatory decision makers. Previously described population exposure and bioaccumulation models were combined to analyze the impact of potential policies on susceptible populations. The combined model simulated the problem of Hg exposure by examining the system from the point of Hg in the water column to its concentration in population biomarkers. Evaluated policy scenarios included the protectiveness of fish consumption advisories, total maximum daily load changes, and watershed management strategies. Simulations indicated that the characteristics of a basin combined with the unique pattern of intake rates of susceptible populations determine the risk associated with fish consumption from a given waterway. Each population had a unique pattern of biomarker response to changes in fish tissue Hg. Management strategies that lowered bioaccumulation rates also reduced ecosystem services. Reducing fish tissue contamination through reductions in Hg loading to watersheds is a long-term solution. For the short-term, fish consumption advisories should be used to protect populations from adverse exposures. The combination of characteristics of the basin and the populations that fish from the waterway should be the determinant for setting advisories. Integr Environ Assess Manag 2013;9:124-133. ß 2012 SETAC

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The Kinetics of Intravenously Administered Methyl Mercury in Man

Cited by 104 publications

References 0 publications

Hair-to-blood ratio and biological half-life of mercury: experimental study of methylmercury exposure through fish consumption in humans

Hair-to-blood ratio and biological half-life of mercury: experimental study of methylmercury exposure through fish consumption in humans

Statistical analysis of a dynamic model for dietary contaminant exposure

Analysis of potential mercury policies: The impact of stream basin characteristics on susceptible populations

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