The kinetic mechanism of cations induced protein nanotubes self-assembly and their application as delivery system

Zhang, Jipeng; Liu, Bin; Li, Dan; Zhang, Huijuan; Wang, Pengjie; Liu, Jinfang; Hou, Guohua; Li, Xin; Yuan, Y. Connie; Li, Zekun; Yan, Huiling; Li, Yuan

doi:10.1016/j.biomaterials.2022.121600

Cited by 22 publications

(41 citation statements)

References 59 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As a consequence, the peptides undergo self-polymerization in the aqueous solution, with the hydrophobic groups aggregating to form a core, while the hydrophilic groups form a shell that interacts with the surrounding water, which results in the formation of simple hydrophobic aggregates. Once the peptide solution reaches a critical concentration threshold, these aggregates further undergo self-assembly into more regular and stable structures driven by kinetic and thermodynamic factors, as well as noncovalent interactions …”

Section: The Forming Mechanism Of the Fpdmps Self-assemblymentioning

confidence: 99%

“…Once the peptide solution reaches a critical concentration threshold, these aggregates further undergo self-assembly into more regular and stable structures driven by kinetic and thermodynamic factors, as well as noncovalent interactions. 23 On the other hand, the self-assembly capability of FPDMPs is often closely associated with their secondary structures, including α-helices, β-sheets, and β-hairpins. 24 α-Helices maintain their stability by means of hydrogen bonding interactions that allow the amino acid side chains to extend outward, forming a helical arrangement.…”

Section: The Forming Mechanism Of the Fpdmps Self-assemblymentioning

confidence: 99%

“…51 The mechanism of nanotube formation was described clearly by previous studies. 23,50 First, partial hydrolysis of α-la results in the release of a few peptide fragments from the original α-la, inducing a conformational change of α-la and exposing the calcium-binding loop. Subsequently, monomeric peptides might assemble into dimers, presumably by hydrophobic interactions and β-sheet stacking, and align together in an orderly manner to form the helical ribbon.…”

Section: Self-assembled Fpdmps With Fibrils Morphologymentioning

confidence: 99%

“…Generally, the self-assembly of FPDMPs involves synergistic noncovalent interactions that result in the formation of well-defined nanostructures. For example, the self-assembly of α-la peptide into nanotubes involves dimerization via hydrophobic interactions, followed by the formation of helical ribbons due to electrostatic repulsion of the carboxyl groups, and finally, the helical ribbons were further self-assembled into nanotubes via electrostatic interactions . Shen et al reported that hydrophobic interactions were mainly responsible for the formation of soy peptide nanoparticles (NPs), while hydrogen bonds and disulfide bonds stabilize the external and internal structure of NPs, respectively .…”

Section: The Forming Mechanism Of the Fpdmps Self-assemblymentioning

confidence: 99%

See 3 more Smart Citations

A Comprehensive Review of Self-Assembled Food Protein-Derived Multicomponent Peptides: From Forming Mechanism and Structural Diversity to Applications

Liu

Zhang

et al. 2023

J. Agric. Food Chem.

View full text Add to dashboard Cite

Food protein-derived multicomponent peptides (FPDMPs) are a natural blend of numerous peptides with various bioactivities and multiple active sites that can assume several energetically favorable conformations in solutions. The remarkable structural characteristics and functional attributes of FPDMPs make them promising codelivery carriers that can coassemble with different bioactive ingredients to induce multidimensional structures, such as fibrils, nanotubes, and nanospheres, thereby producing specific health benefits. This review offers a prospective analysis of FPDMPs-based self-assembly nanostructures, focusing on the mechanism of formation of self-assembled FPDMPs, the internal and external stimuli affecting peptide self-assembly, and their potential applications. In particular, we introduce the exciting prospect of constructing functional materials through precursor template-induced self-assembly of FPDMPs, which combine the bioactivity and self-assembly capacity of peptides and could dramatically broaden the functional utility of peptide-based materials.

show abstract

Section: The Forming Mechanism Of the Fpdmps Self-assemblymentioning

confidence: 99%

Section: The Forming Mechanism Of the Fpdmps Self-assemblymentioning

confidence: 99%

Section: Self-assembled Fpdmps With Fibrils Morphologymentioning

confidence: 99%

Section: The Forming Mechanism Of the Fpdmps Self-assemblymentioning

confidence: 99%

See 2 more Smart Citations

A Comprehensive Review of Self-Assembled Food Protein-Derived Multicomponent Peptides: From Forming Mechanism and Structural Diversity to Applications

Liu

Zhang

et al. 2023

J. Agric. Food Chem.

View full text Add to dashboard Cite

show abstract

“…In a very recent report, Zhang et al [184] utilized amphiphilic α-lactalbumin nanotubes to encapsulate curcumin and improve its solubility, stability, bioavailability, and bioactivity. The fabrication mechanism of the nanotubes was investigated by regulating the self-assembly phenomenon of the building block based on enzymolyzed protein at 50 °C.…”

Section: Bioinspired Nanotubular Carriersmentioning

confidence: 99%

Biopolymer Nanovehicles for Oral Delivery of Natural Anticancer Agents

Falsafi

Wang

Ashaolu

et al. 2022

Adv Funct Materials

View full text Add to dashboard Cite

Cancer is the second leading cause of death throughout the world. Nature‐inspired anticancer agents (NAAs) that are a gift of nature to humanity have been extensively utilized in the alleviation/prevention of the disease due to their numerous pharmacological activities. While the oral route is an ideal and common way of drug administration, the application of NAAs through the oral pathway has been extremely limited owing to their inherent features, e.g., poor solubility, gastrointestinal (GI) instability, and low bioavailability. With the development of nano‐driven encapsulation strategies, polymeric vehicles, especially those with natural origins, have demonstrated a potent platform, which can professionally shield versatile NAAs against GI barricades and safely deliver them to the site of action. In this review, the predicament of orally delivering NAAs and the encapsulation strategy solutions based on biopolymer matrices are summarized. Proof‐of‐concept in vitro/in vivo results are also discussed for oral delivery of these agents by various biopolymer vehicles, which can be found so far from the literature. Last but not the least, the challenges and new opportunities in the field are highlighted.

show abstract

Natural Phenolic‐Metal Framework Strengthened Mesona Chinensis Polysaccharides Microgels for Improved Viability of Probiotics to Alleviate the Liver Injury and Gut Microbiota Dysbiosis

Zhang,

Liu

et al. 2024

Adv Funct Materials

View full text Add to dashboard Cite

Oral probiotics meet challenges during processing, storage, and gastrointestinal harsh conditions. Polysaccharide‐based hydrogels delivery system is promising in probiotic protection, but its semi‐solid and weak strength, and often requires additional cross‐links to solidify its structure. Herein a ferric ion co‐crosslinked microgel of Mesona chinensis polysaccharides and mechanically strengthened by phenolic‐metal frameworks of naturally bound brown bioactives is designed. These microgels has an intact structure in acidic condition and ruptured only at pH neutral conditions which can responsively release highly viable probiotics with high mucoadhesion and colonization. Brown bioactives are naturally bound to polysaccharides (MCPC) by hydrophobic interactions and hydrogen bonding, and they exhibited outstanding anti‐inflammatory and antioxidant properties. Moreover, these brown bioactives are the precise prebiotics which can specifically improve the abundance of Akkermansia genus in gut in vivo. Then, the probiotics Akkermansia muciniphila (AKK) are loaded into brown bioactives frameworks strengthened microgels. There is a more synergistic healthy benefit between MCPC components and loaded AKK compared with free and pasteurized AKK. MCPC microgels can deliver high viable AKK specifically to gut consequently modulating the microbiota balance, and protecting the intestinal barriers. MCPC microgels also delivered the antioxidant brown bioactives specifically into liver to alleviate the hepatic oxidative stress and inflammation.

show abstract

The kinetic mechanism of cations induced protein nanotubes self-assembly and their application as delivery system

Cited by 22 publications

References 59 publications

A Comprehensive Review of Self-Assembled Food Protein-Derived Multicomponent Peptides: From Forming Mechanism and Structural Diversity to Applications

A Comprehensive Review of Self-Assembled Food Protein-Derived Multicomponent Peptides: From Forming Mechanism and Structural Diversity to Applications

Biopolymer Nanovehicles for Oral Delivery of Natural Anticancer Agents

Natural Phenolic‐Metal Framework Strengthened Mesona Chinensis Polysaccharides Microgels for Improved Viability of Probiotics to Alleviate the Liver Injury and Gut Microbiota Dysbiosis

Contact Info

Product

Resources

About