The Kinetic Change of the Serum Angiogenin Level in Patients with Acute Cerebral Infarction

Abstract

Serum angiogenin (ANG) levels were measured with ELISA in 30 cerebral infarction patients at different time points (within 48 h and on days 3, 7 and 14 after onset of cerebral infarction) and in 20 control subjects. Serum ANG levels in patients were 415.1 ± 76.8, 410.6 ± 82.1, 443.6 ± 91.1 and 395.3 ± 83.9 ng/ml within 48 h and on days 3, 7 and 14 after cerebral infarction, respectively. Serum ANG level in control group was 334.9 ± 93.9 ng/ml. Serum ANG levels were significantly higher in patients with cerebral infarction within 48 h and on days 3 and 7 than in the control group (p < 0.05). Serum ANG level decreased on day 14. Serum ANG levels were significantly higher in patients with large infarction than in those with moderate and small infarction at each time point (p < 0.05). Our observations that serum ANG levels increase significantly in patients with cerebral infarction and the increase in ANG levels correlates with the infarct size suggest that ANG might be involved in the pathophysiologic process of ischemic brain damage.

Vascular Disruption and the Role of Angiogenic Proteins After Spinal Cord Injury

“…Certain patterns of change present after SCI in our sample population could potentially have been masked by this great inter-individual variation, as it would be logistically impossible to acquire a non-SCI baseline measure for each SCI patient enrolled in this study to use as a comparison for their post-SCI expression values. However, a majority of the values recorded for our non-SCI controls reflect the values of controls which have previously been reported (Table 3) [6, 29, 31, 68, 80, 84, 95, 98, 101, 103, 112, 138, 140, 141, 152, 157, 174, 192]. …”

Importance of Angiogenin and Endothelial Progenitor Cells After Rehabilitation Both in Ischemic Stroke Patients and in a Mouse Model of Cerebral Ischemia

“…Angiogenin has also been studied in cardiovascular diseases showing an increase in blood in chronic heart failure or in acute coronary syndrome in association with severity or prognosis ( 51 , 52 ). In the context of stroke, Huang et al reported that higher serum angiogenin levels within the first week after stroke are associated with larger infarct size ( 53 ). This up-regulation of angiogenin in the acute phase of cardiovascular diseases has also been observed in our study by identifying angiogenin in neurons or vessels of the brain within the first 4 days in infarcted areas.…”

Effects of Chitosan on the Secretion of Cytokines and Expression of Inducible Nitric Oxide Synthase mRNA in Peritoneal Macrophages of Broiler Chicken

“…The levels of IL-1, IL-2 and TNF-α in the culture liquid of peritoneal macrophage were measured by radioimimunoassay according to the manufacturer's instructions (Zhang et al 2008). The kits of the three cytokines were produced by Beijing Huaying Institute of Biotechnology and the detecting instrument was GC-911-γ-radioimmunity arithmometer.…”