1993
DOI: 10.1002/dmr.5610090105
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The kidney disease of diabetes mellitus (KDDM): A cell and molecular biology approach

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Cited by 41 publications
(24 citation statements)
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“…Diabetes mellitus is a common metabolic disorder in which the hyperglycemic state seems to adversely affect the homeostasis of various organ systems, including the kidney (1,2). The pathologic changes of the kidney are characterized by biochemical alterations of the extracellular matrix (ECM) 1 macromolecules; the latter are believed to regulate morphogenesis of different organ systems (3,4).…”
Section: Introductionmentioning
confidence: 99%
“…Diabetes mellitus is a common metabolic disorder in which the hyperglycemic state seems to adversely affect the homeostasis of various organ systems, including the kidney (1,2). The pathologic changes of the kidney are characterized by biochemical alterations of the extracellular matrix (ECM) 1 macromolecules; the latter are believed to regulate morphogenesis of different organ systems (3,4).…”
Section: Introductionmentioning
confidence: 99%
“…MC have been postulated to be major contributors to glomerulosclerotic lesions (19) and have been demonstrated to express MMP-9 in certain species and experimental conditions (20 -22). The behavior of MC in vitro might be different from that in vivo, and behavior is influenced by the substrate and cell culture conditions (23).…”
mentioning
confidence: 99%
“…A subgroup ofpatients with diabetes mellitus may experience glomerulosclerosis as a result of mesangial expansion, a process that can progress to renal failure (1). The proximal cause of this process differs from that of the nephrosclerosis of aging, which more likely reflects the effects of vascular lesions with atrophic glomeruli and ischemia (2).…”
mentioning
confidence: 99%