The Key Genes Underlying Pathophysiology Correlation Between the Acute Myocardial Infarction and COVID-19

You, Hongjian; Zhao, Qianqian; Dong, Mingjie

doi:10.2147/ijgm.s354885

Cited by 7 publications

(5 citation statements)

References 74 publications

(61 reference statements)

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“…Cardiovascular complications caused by COVID-19 have been the focus of much attention, including the pathogenesis of COVID-19 comorbidities of cardiovascular diseases, such as acute myocardial infarction and myocarditis [ 19 , 20 ]. Disease signature genes for COVID-19 or ICM have also been reported.…”

Section: Discussionmentioning

confidence: 99%

Exploring Potential Biomarkers and Molecular Mechanisms of Ischemic Cardiomyopathy and COVID-19 Comorbidity Based on Bioinformatics and Systems Biology

Luo

Zhang

et al. 2023

IJMS

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Cardiovascular complications combined with COVID-19 (SARS-CoV-2) lead to a poor prognosis in patients. The common pathogenesis of ischemic cardiomyopathy (ICM) and COVID-19 is still unclear. Here, we explored potential molecular mechanisms and biomarkers for ICM and COVID-19. Common differentially expressed genes (DEGs) of ICM (GSE5406) and COVID-19 (GSE164805) were identified using GEO2R. We performed enrichment and protein–protein interaction analyses and screened key genes. To confirm the diagnostic performance for these hub genes, we used external datasets (GSE116250 and GSE211979) and plotted ROC curves. Transcription factor and microRNA regulatory networks were constructed for the validated hub genes. Finally, drug prediction and molecular docking validation were performed using cMAP. We identified 81 common DEGs, many of which were enriched in terms of their relation to angiogenesis. Three DEGs were identified as key hub genes (HSP90AA1, HSPA9, and SRSF1) in the protein–protein interaction analysis. These hub genes had high diagnostic performance in the four datasets (AUC > 0.7). Mir-16-5p and KLF9 transcription factor co-regulated these hub genes. The drugs vindesine and ON-01910 showed good binding performance to the hub genes. We identified HSP90AA1, HSPA9, and SRSF1 as markers for the co-pathogenesis of ICM and COVID-19, and showed that co-pathogenesis of ICM and COVID-19 may be related to angiogenesis. Vindesine and ON-01910 were predicted as potential therapeutic agents. Our findings will contribute to a deeper understanding of the comorbidity of ICM with COVID-19.

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Section: Discussionmentioning

confidence: 99%

Exploring Potential Biomarkers and Molecular Mechanisms of Ischemic Cardiomyopathy and COVID-19 Comorbidity Based on Bioinformatics and Systems Biology

Luo

Zhang

et al. 2023

IJMS

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“…Alternative polyadenylation of innate, immune-related mRNAs is observed in COVID-19 patients [81]. Moreover, CPSF2 has been identified amongst the top-30 hub genes that underlie the pathophysiological link between acute myocardial infarction and COVID-19 [82].…”

Section: Genes/proteins Identified By 1-l Transcription Of N-(aa)n-c ...mentioning

confidence: 99%

“…In patients with severe COVID-19, infected cells and monocytes upregulate their surface expression of NECTIN2/CD112, leading to NK cell exhaustion and, hence, to SARS-CoV-2 escape [67]. CPSF2 was identified among the top-30 hub genes underlying the pathophysiological correlation between acute myocardial infarction and COVID-19 [82].…”

Section: Genes/proteins Known To Be Related To Covid-19mentioning

confidence: 99%

1-L Transcription of SARS-CoV-2 Spike Protein S1 Subunit

Nahalka

2024

IJMS

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The COVID-19 pandemic prompted rapid research on SARS-CoV-2 pathogenicity. Consequently, new data can be used to advance the molecular understanding of SARS-CoV-2 infection. The present bioinformatics study discusses the “spikeopathy” at the molecular level and focuses on the possible post-transcriptional regulation of the SARS-CoV-2 spike protein S1 subunit in the host cell/tissue. A theoretical protein–RNA recognition code was used to check the compatibility of the SARS-CoV-2 spike protein S1 subunit with mRNAs in the human transcriptome (1-L transcription). The principle for this method is elucidated on the defined RNA binding protein GEMIN5 (gem nuclear organelle-associated protein 5) and RNU2-1 (U2 spliceosomal RNA). Using the method described here, it was shown that 45% of the genes/proteins identified by 1-L transcription of the SARS-CoV-2 spike protein S1 subunit are directly linked to COVID-19, 39% are indirectly linked to COVID-19, and 16% cannot currently be associated with COVID-19. The identified genes/proteins are associated with stroke, diabetes, and cardiac injury.

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“…Interestingly, the autophagy-lysosome pathway plays an important role in inflammatory injury during infections, such as with the pathogen severe acute respiratory syndrome coronavirus (SARS-CoV-2) [223][224][225][226][227][228][229][230][231]. Yet, processes involving autophagy hold a significant role in cognitive function [27,95,98,[232][233][234][235].…”

Section: Cellular Metabolism and The Role Of Apoptosis Autophagy And ...mentioning

confidence: 99%

“…In particular, APOE-ε4 may promote the susceptibility of viral infection and cerebrovascular disease during COVID-19 [368]. The β-coronavirus family virion, severe acute respiratory syndrome (SARS) -CoV-2 (SARS-CoV-2), has led to multiple and repeated infections throughout the global population [8,27,[223][224][225][226][227][228]312,350,[369][370][371][372]. Coronaviruses are ribonucleic acid (RNA) viruses and are members of the family of Coronaviridae and the subfamily of Orthocoronavirinae [27,241,[373][374][375][376][377].…”

Section: Cellular Metabolism and The ε4 Allele Of The Apolipoprotein ...mentioning

confidence: 99%

Cellular Metabolism: A Fundamental Component of Degeneration in the Nervous System

Maiese

2023

Biomolecules

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It is estimated that, at minimum, 500 million individuals suffer from cellular metabolic dysfunction, such as diabetes mellitus (DM), throughout the world. Even more concerning is the knowledge that metabolic disease is intimately tied to neurodegenerative disorders, affecting both the central and peripheral nervous systems as well as leading to dementia, the seventh leading cause of death. New and innovative therapeutic strategies that address cellular metabolism, apoptosis, autophagy, and pyroptosis, the mechanistic target of rapamycin (mTOR), AMP activated protein kinase (AMPK), growth factor signaling with erythropoietin (EPO), and risk factors such as the apolipoprotein E (APOE-ε4) gene and coronavirus disease 2019 (COVID-19) can offer valuable insights for the clinical care and treatment of neurodegenerative disorders impacted by cellular metabolic disease. Critical insight into and modulation of these complex pathways are required since mTOR signaling pathways, such as AMPK activation, can improve memory retention in Alzheimer’s disease (AD) and DM, promote healthy aging, facilitate clearance of β-amyloid (Aß) and tau in the brain, and control inflammation, but also may lead to cognitive loss and long-COVID syndrome through mechanisms that can include oxidative stress, mitochondrial dysfunction, cytokine release, and APOE-ε4 if pathways such as autophagy and other mechanisms of programmed cell death are left unchecked.

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The Key Genes Underlying Pathophysiology Correlation Between the Acute Myocardial Infarction and COVID-19

Cited by 7 publications

References 74 publications

Exploring Potential Biomarkers and Molecular Mechanisms of Ischemic Cardiomyopathy and COVID-19 Comorbidity Based on Bioinformatics and Systems Biology

Exploring Potential Biomarkers and Molecular Mechanisms of Ischemic Cardiomyopathy and COVID-19 Comorbidity Based on Bioinformatics and Systems Biology

1-L Transcription of SARS-CoV-2 Spike Protein S1 Subunit

Cellular Metabolism: A Fundamental Component of Degeneration in the Nervous System

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