The Ketogenic Diet in Epilepsy

Peterman, M. G.

doi:10.1001/jama.1925.02660520007003

Cited by 163 publications

(75 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In 1920, refractory epilepsia in children was treated in such a way with considerable success [114,115]. Currently, the ketogenic diet is an adjunct therapy of choice, supporting the pharmacological treatment of epilepsy, or as a principal treatment method in drug-resistant cases, highlighting the efficacy in decreasing seizure frequency, especially in children [116,117].…”

Section: Neuroprotective and Therapeutic Activity Of Ketone Bodiesmentioning

confidence: 99%

Regulation of Ketone Body Metabolism and the Role of PPARα

Grabacka

Pierzchalska

Dean

et al. 2016

IJMS

241

202

View full text Add to dashboard Cite

Ketogenesis and ketolysis are central metabolic processes activated during the response to fasting. Ketogenesis is regulated in multiple stages, and a nuclear receptor peroxisome proliferator activated receptor α (PPARα) is one of the key transcription factors taking part in this regulation. PPARα is an important element in the metabolic network, where it participates in signaling driven by the main nutrient sensors, such as AMP-activated protein kinase (AMPK), PPARγ coactivator 1α (PGC-1α), and mammalian (mechanistic) target of rapamycin (mTOR) and induces hormonal mediators, such as fibroblast growth factor 21 (FGF21). This work describes the regulation of ketogenesis and ketolysis in normal and malignant cells and briefly summarizes the positive effects of ketone bodies in various neuropathologic conditions.

show abstract

Section: Neuroprotective and Therapeutic Activity Of Ketone Bodiesmentioning

confidence: 99%

Regulation of Ketone Body Metabolism and the Role of PPARα

Grabacka

Pierzchalska

Dean

et al. 2016

IJMS

241

202

View full text Add to dashboard Cite

show abstract

“…The clinical success of this diet has been well described for nearly 80 years [Wilder, 1921;Peterman, 1925;Helmholz and Keith, 1930;Huttenlocher et al, 1971;Livingston, 1972;DeVivo et al, 1973;Schwartz et al, 1989;Kinsman et al, 1992;Freeman et al, 1994;Nordli and DeVivo, 1997;Swink et al, 1997;Freeman et al, 1998]. Nevertheless, there is little known about the mechanism of action of the diet as a treatment for epileptic children.…”

Section: Introductionmentioning

confidence: 99%

Path Analysis Shows That Increasing Ketogenic Ratio, but Not β-Hydroxybutyrate, Elevates Seizure Threshold in the Rat

Bough¹,

Chen²,

Eagles³

1999

Dev Neurosci

View full text Add to dashboard Cite

Previous work has identified several criteria that may be important in determining the efficacy of the ketogenic diet as a treatment for intractable epilepsy in children. The present study was designed to investigate the influence of four major variables on seizure threshold, i.e. ketogenic ratio, body weight, age at diet onset and β-hydroxybutyrate in rats. Path analysis was used to statistically model and quantify the causal relationships among variables. Results indicate that seizure threshold was significantly elevated with increasing ketogenic ratios (i.e. more fats vs. carbohydrates and proteins) and decreasing weight. Conversely, age at diet onset and plasma levels of β-OHB showed no causal relation to seizure resistance. These results suggest that the efficacy of the ketogenic diet is independent of the level of ketonemia but is markedly influenced by diet and growth.

show abstract

“…The fi rst results demonstrating the benefi cial effects of the KD on seizure reduction in epileptic children were published by Dr. M. G. Peterman, a pediatrician from the Mayo Clinic ( 25,26 ). And during an era when anti-seizure drugs (ASDs) were scarce, the KD became quickly popularized in large medical centers.…”

mentioning

confidence: 99%