The ketamine metabolite (2R,6R)‐hydroxynorketamine rescues hippocampal mRNA translation, synaptic plasticity and memory in mouse models of Alzheimer's disease
Felipe C. Ribeiro,
Danielle Cozachenco,
Elentina K. Argyrousi
et al.
Abstract:INTRODUCTIONImpaired brain protein synthesis, synaptic plasticity, and memory are major hallmarks of Alzheimer's disease (AD). The ketamine metabolite (2R,6R)‐hydroxynorketamine (HNK) has been shown to modulate protein synthesis, but its effects on memory in AD models remain elusive.METHODSWe investigated the effects of HNK on hippocampal protein synthesis, long‐term potentiation (LTP), and memory in AD mouse models.RESULTSHNK activated extracellular signal‐regulated kinase 1/2 (ERK1/2), mechanistic target of … Show more
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