The juvenile hormones: historical facts and speculations on future research directions

Gilbert, Lawrence I.; Granger, Noelle A.; Roe, R. Michael

doi:10.1016/s0965-1748(00)00034-5

Cited by 385 publications

(296 citation statements)

References 180 publications

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“…22,23 It has been demonstrated that hexamerins are endocytosed by fat body cells and act as storage proteins during larval feeding prior to metamorphosis. 24 The hexamerin receptor is classified as a member of the low density lipoprotein superfamily 22 and Figure 3. hemolymph protein binding profile from larvae primed with A. fumigatus conidia.…”

Section: ©2 0 1 1 L a N D E S B I O S C I E N C E D O N O T D I S Tmentioning

confidence: 99%

Pre-exposure ofGalleria mellonellalarvae to different doses ofAspergillus fumigatusconidia causes differential activation of cellular and humoral immune responses

2011

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Section: ©2 0 1 1 L a N D E S B I O S C I E N C E D O N O T D I S Tmentioning

confidence: 99%

Pre-exposure ofGalleria mellonellalarvae to different doses ofAspergillus fumigatusconidia causes differential activation of cellular and humoral immune responses

2011

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“…[reviewed in (Gilbert et al, 2000)]. For instance, in the wing polymorphism of crickets, it has been strongly suggested that the reduced JHE activity elevates JH titers, specifying the development of the short-winged morph (Zera, 2003;Zera, 2006;Zera et al, 2007).…”

Section: Jhes Are Known To Play Important Roles In Jh Degradation Lomentioning

confidence: 99%

Juvenile hormone titre and related gene expression during the change of reproductive modes in the pea aphid

Ishikawa

Ogawa

Gotoh

et al. 2011

Insect Molecular Biology

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Most aphids show reproductive polyphenism, i.e. they alternate their reproductive modes from parthenogenesis to sexual reproduction in response to short photoperiod. Although juvenile hormone (JH) has been considered a likely candidate for regulating the transition from asexual to sexual reproduction after photoperiod sensing, there are few studies investigating the direct relationship between JH titers and the reproductive mode change. In addition, the sequencing of the pea aphid genome now allows identification of the genes involved in the JH pathway which then allows us to examine their expression levels in relation to the reproductive-mode switch. Using LC-MS in the pea aphid, JHIII titer was shown to be lower in aphids producing sexual morphs under short-days than in aphids producing parthenogenetic morphs in long-days. The expression levels of genes upstream and downstream of JH action were quantified by real-time qRT-PCR across the reproductive mode change. The expression level of JH esterase (JHE), which is responsible for JH degradation, was significantly higher in aphids reared under short-days. This suggests that the up-regulation of the JH degradation pathway may be responsible for the lower JHIII titer in aphids exposed to short-days, leading to the production of sexual morphs.

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“…The mode of JH action, however, is still not fully understood (Wheeler and Nijhout, 2003). The lipidsoluble nature of JH has suggested action directly on the genome through nuclear receptors similar to the action of ecdysteroids and the vertebrate steroid/thyroid/ retinoid hormones (Jones, 1995;Gilbert et al, 2000). However, the action of JH through the cell membrane was also documented (Yamamoto et al, 1988;Sevala and Davey, 1989).…”

Section: Introductionmentioning

confidence: 99%

Interaction of proteins involved in ecdysone and juvenile hormone signal transduction

Bitra

Palli

2008

Arch Insect Biochem Physiol

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Ecdysteroids and juvenile hormones (JH) regulate a variety of developmental, physiological, behavioral, and metabolic processes. Ecdysteroids function through a heterodimeric complex of two nuclear receptors, ecdysone receptor (EcR) and ultraspiracle (USP). An 85 kDa protein identified in Drosophila melanogaster methoprene‐tolerant (Met) mutant binds to JH III with high affinity, and the mutant flies are resistant to juvenile hormone analog (JHA), methoprene. Reporter assays using the yeast two‐hybrid system were performed in order to study the molecular interactions between EcR, USP and Met. As expected, EcR fused to the B42 activation domain and USP fused to the LexA DNA binding domain interacted with each other and supported induction of the reporter gene in the presence of stable ecdysteroid analog, RG‐102240 or steroids, muristerone A and ponasterone A. The USP:USP homodimers supported expression of the reporter gene in the absence of ligand, and there was no significant increase in the reporter activity after addition of a JHA, methoprene. Similarly, Met:Met homodimers as well as Met:EcR and Met:USP heterodimers induced reporter activity in the absence of ligand and addition of ecdysteroid or JH analogs did not increase the reporter activity regulated by either homodimers or heterodimers of Met protein. Two‐hybrid assays in insect cells and in vitro pull‐down assays confirmed the interaction of Met with EcR and USP. These data suggest that the proteins that are involved in signal transduction of ecdysteroids (EcR and USP) and juvenile hormones (Met) interact to mediate cross‐talk between these two important hormones. Arch. Insect Biochem. Physiol. 2008. © 2008 Wiley‐Liss, Inc.

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The juvenile hormones: historical facts and speculations on future research directions

Cited by 385 publications

References 180 publications

Pre-exposure ofGalleria mellonellalarvae to different doses ofAspergillus fumigatusconidia causes differential activation of cellular and humoral immune responses

Pre-exposure ofGalleria mellonellalarvae to different doses ofAspergillus fumigatusconidia causes differential activation of cellular and humoral immune responses

Juvenile hormone titre and related gene expression during the change of reproductive modes in the pea aphid

Interaction of proteins involved in ecdysone and juvenile hormone signal transduction

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