The journey of multifunctional bone scaffolds fabricated from traditional toward modern techniques

Bigham, Ashkan; Foroughi, Firoozeh; Ghomi, Erfan Rezvani; Rafienia, Mohammad; Neisiany, Rasoul Esmaeely; Ramakrishna, Seeram

doi:10.1007/s42242-020-00094-4

Cited by 76 publications

(45 citation statements)

References 165 publications

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“…Bone is a self-healing tissue when a small defect occurs. However, treating critical defects, such as pathological fractures and complex breaks, is still a big challenge [ 164 , 165 ]. PLLA-based scaffolds could provide functional support for bone tissue repair.…”

Section: Applications Of Plla-based Scaffold In Tissue Engineeringmentioning

confidence: 99%

Poly-l-Lactic Acid (PLLA)-Based Biomaterials for Regenerative Medicine: A Review on Processing and Applications

et al. 2022

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Synthetic biopolymers are effective cues to replace damaged tissue in the tissue engineering (TE) field, both for in vitro and in vivo application. Among them, poly-l-lactic acid (PLLA) has been highlighted as a biomaterial with tunable mechanical properties and biodegradability that allows for the fabrication of porous scaffolds with different micro/nanostructures via various approaches. In this review, we discuss the structure of PLLA, its main properties, and the most recent advances in overcoming its hydrophobic, synthetic nature, which limits biological signaling and protein absorption. With this aim, PLLA-based scaffolds can be exposed to surface modification or combined with other biomaterials, such as natural or synthetic polymers and bioceramics. Further, various fabrication technologies, such as phase separation, electrospinning, and 3D printing, of PLLA-based scaffolds are scrutinized along with the in vitro and in vivo applications employed in various tissue repair strategies. Overall, this review focuses on the properties and applications of PLLA in the TE field, finally affording an insight into future directions and challenges to address an effective improvement of scaffold properties.

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Section: Applications Of Plla-based Scaffold In Tissue Engineeringmentioning

confidence: 99%

Poly-l-Lactic Acid (PLLA)-Based Biomaterials for Regenerative Medicine: A Review on Processing and Applications

et al. 2022

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“…Type I collagen is extensively common in animals, 55 chiefly composing the organic phase of the ECM of noncartilaginous tissues, such as dermis, tendon, cornea, and bones 56 . These tissues are composed of complex fibrils with distinct morphologies and functionalities.…”

Section: Introductionmentioning

confidence: 99%

Collagen‐based biomaterials for biomedical applications

et al. 2021

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Collagen is an insoluble fibrous protein that composes the extracellular matrix in animals. Although collagen has been used as a biomaterial since 1881, the properties and the complex structure of collagen are still extensive study subjects worldwide. In this article, several topics of importance for understanding collagen research are reviewed starting from its historical milestones, followed by the description of the collagen superfamily and its complex structures, with a focus on type I collagen. Subsequently, some of the superior properties of collagen‐based biomaterials, such as biocompatibility, biodegradability, mechanical properties, and cell activities, are pinpointed. These properties make collagen applicable in biomedicine, such as wound healing, tissue engineering, surface coating of medical devices, and skin supplementation. Moreover, some antimicrobial strategies and the general host tissue responses regarding collagen as a biomaterial are presented. Finally, the current status and clinical application of the three‐dimensional (3D) printing techniques for the fabrication of collagen‐based scaffolds and the reconstruction of the human heart's constituents, such as capillary structures or even the entire organ, are discussed. Besides, an overall outlook for the future of this unique biomaterial is provided.

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“…Furthermore, with the inherent biocompatible properties of nylon, it has been used in the biomedical industry since the 1970s. Nylon has recently drawn more attention in biomedical industries because its promising potential in tissue engineering and regenerative medicine had become more evident 10,11 …”

Section: Introductionmentioning

confidence: 99%

Nylon—A material introduction and overview for biomedical applications

Shakiba

Ghomi

Khosravi

et al. 2021

Polymers for Advanced Techs

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Nylon is a human‐made material and has been applied in many industrial fields. This literature review explores the use of nylon in biomedical applications and discusses the properties and three‐dimensional (3D) printability of this material. Nylon is studied due to its versatility as an engineering plastic that can be easily transformed into fibers, films, and molded parts. Due to nylon's biocompatible nature, it has desirable chemical stability and tunable mechanical properties making this material and its derivatives widely used as sutures, catheters, dentures, and so on. However, the interactions between nylon and human body tissues have yet to be fully understood. Nevertheless, nylon is hybridized with different materials and used as skin dressings. In recent years, nylon composites have been actively researched in tissue engineering as an alternative to metallic implants with an appropriate bioactivity potential for bone growth. As nylon is supposed to be in contact with the tissue for a long time, hence researchers are developing antimicrobial strategies for the nylon materials to even promote their potential a step further. The 3D printing of nylon is currently confined to specific applications due to the printing technology's current limitations.

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The journey of multifunctional bone scaffolds fabricated from traditional toward modern techniques

Cited by 76 publications

References 165 publications

Poly-l-Lactic Acid (PLLA)-Based Biomaterials for Regenerative Medicine: A Review on Processing and Applications

Poly-l-Lactic Acid (PLLA)-Based Biomaterials for Regenerative Medicine: A Review on Processing and Applications

Collagen‐based biomaterials for biomedical applications

Nylon—A material introduction and overview for biomedical applications

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