The joint role of methylation and immune-related lncRNAs in ovarian cancer: Defining molecular subtypes and developing prognostic signature

Gao, Kefei; Lian, Wenqin; Zhao, Rui; Huang, Wei‐Ming; Xiong, Jie

doi:10.1016/j.tranon.2023.101704

Cited by 2 publications

(3 citation statements)

References 53 publications

(53 reference statements)

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“…Clustering analysis performed in the context of CRC and ovarian cancers have revealed a heightened prevalence of Tregs within the high-risk patient cohort. This elevated accumulation of Tregs aligns with an associated decline in overall survival 90 , 96 .…”

Section: The Roles Of M7g Modification In Immune Cell Biologysupporting

confidence: 53%

“…In the context of head and neck squamous cell carcinoma (HNSCC), cluster analysis utilizing the ESTIMATE and CIBERSORT algorithms has revealed a higher proportion of CD8 + T cells in the low-risk group 85 . Studies conducted in CRC, prostate cancer, soft tissue sarcoma (STS), gastric cancer (GC), and ovarian cancer have suggested a similar regulatory pattern 86 - 90 . However, CD4 + cells displayed varying abundances across different cancer subtypes and types.…”

Section: The Roles Of M7g Modification In Immune Cell Biologymentioning

confidence: 99%

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M7G-related tumor immunity: novel insights of RNA modification and potential therapeutic targets

Han,

Huang,

et al. 2024

Int. J. Biol. Sci.

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RNA modifications play a pivotal role in regulating cellular biology by exerting influence over distribution features and molecular functions at the post-transcriptional level. Among these modifications, N7-methylguanosine (m7G) stands out as one of the most prevalent. Over recent years, significant attention has been directed towards understanding the implications of m7G modification. This modification is present in diverse RNA molecules, including transfer RNAs, messenger RNAs, ribosomal RNAs, and other noncoding RNAs. Its regulation occurs through a series of specific methyltransferases and m7G-binding proteins. Notably, m7G modification has been implicated in various diseases, prominently across multiple cancer types. Earlier studies have elucidated the significance of m7G modification in the context of immune biology regulation within the tumor microenvironment. This comprehensive review culminates in a synthesis of findings related to the modulation of immune cells infiltration, encompassing T cells, B cells, and various innate immune cells, all orchestrated by m7G modification. Furthermore, the interplay between m7G modification and its regulatory proteins can profoundly affect the efficacy of diverse adjuvant therapeutics, thereby potentially serving as a pivotal biomarker and therapeutic target for combinatory interventions in diverse cancer types.

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Section: The Roles Of M7g Modification In Immune Cell Biologysupporting

confidence: 53%

Section: The Roles Of M7g Modification In Immune Cell Biologymentioning

confidence: 99%

M7G-related tumor immunity: novel insights of RNA modification and potential therapeutic targets

Han,

Huang,

et al. 2024

Int. J. Biol. Sci.

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“…Long noncoding RNAs (lncRNAs) are capable of regulating diverse biological processes, including differentiation, development, and the cell cycle [ 6 ]. Evidence supports the implication of lncRNAs as either triggers or suppressors of cell viability, metastasis, and tumor development in ovarian cancer [ 7 – 10 ]. The lncRNA family with sequence similarity 225 members B (FAM225B, also called LINC00256B) is a newly discovered lncRNA whose expression is altered in several cancers, such as renal cell carcinoma, bladder cancer, and papillary thyroid carcinoma [ 11 – 13 ].…”

Section: Introductionmentioning

confidence: 96%

LncRNA FAM225B Regulates PDIA4-Mediated Ovarian Cancer Cell Invasion and Migration via Modulating Transcription Factor DDX17

Yao,

Zeng,

Liu

et al. 2023

The Breast Journal

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Objective. This study aimed to explore the roles and mechanisms of lncRNA FAM225B and PDIA4 in ovarian cancer. Methods. RT-qPCR and Western blot assays were performed to detect the expression levels of the lncRNAs FAM225B, DDX17, and PDIA4 in the serum of patients with ovarian cancer and cell lines. Cells were transfected with lncRNA FAM225B- and PDIA4-related vectors to determine the malignant phenotypes using functional experiments. The mutual binding of lncRNA FAM225B and DDX17 was verified using RNA pull-down and RIP assays. Results. The expression of lncRNAs FAM225B and PDIA4 was decreased in the serum of patients with ovarian cancer and cell lines. Restoration of lncRNA FAM225B or PDIA4 reduced cell proliferation, migration, and invasion abilities and elevated the apoptosis rate, whereas suppression of lncRNA FAM225B or PDIA4 exhibited an inverse trend. RNA pull-down and RIP assays revealed a direct interaction between lncRNA FAM225B and DDX17. ChIP assay revealed a relationship between DDX17 and the PDIA4 promoter. LncRNA FAM225B and DDX17 positively regulate PDIA4 expression. Downregulation of PDIA4 expression counteracts the suppressive effect of lncRNA FAM225B overexpression in ovarian cancer cells. Conclusion. This research study supports the fact that lncRNA FAM225B in ovarian cancer can upregulate PDIA4 by directly binding to DDX17, inhibiting the activities of ovarian cancer cells.

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The joint role of methylation and immune-related lncRNAs in ovarian cancer: Defining molecular subtypes and developing prognostic signature

Cited by 2 publications

References 53 publications

M7G-related tumor immunity: novel insights of RNA modification and potential therapeutic targets

M7G-related tumor immunity: novel insights of RNA modification and potential therapeutic targets

LncRNA FAM225B Regulates PDIA4-Mediated Ovarian Cancer Cell Invasion and Migration via Modulating Transcription Factor DDX17

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