2008
DOI: 10.1016/j.jhep.2008.05.015
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The JNK inhibitor SP600129 enhances apoptosis of HCC cells induced by the tumor suppressor WWOX

Abstract: WWOX induces apoptosis and inhibits human HCC cell growth through a mechanism enhanced by JNK inhibition.

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Cited by 43 publications
(42 citation statements)
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“…One of the roles of WWOX protein is participation in steroid hormone metabolism (14,15). Results of previous studies showed that WWOX is also associated with apoptosis, proliferation, adhesion and cell signaling pathways (16)(17)(18)(19). Additionally, WWOX has been shown to bind to PPxY motif-containing proteins, and inactivate their transcription transactivation function by sequestering them in the cytoplasm (20,21).…”
Section: Introductionmentioning
confidence: 99%
“…One of the roles of WWOX protein is participation in steroid hormone metabolism (14,15). Results of previous studies showed that WWOX is also associated with apoptosis, proliferation, adhesion and cell signaling pathways (16)(17)(18)(19). Additionally, WWOX has been shown to bind to PPxY motif-containing proteins, and inactivate their transcription transactivation function by sequestering them in the cytoplasm (20,21).…”
Section: Introductionmentioning
confidence: 99%
“…Chang et al determined that WWOX is the key factor of p53 in apoptosis (11). WWOX may therefore enhance the apoptosis-inducing activity of p53 (6). In addition, A549 is a p53-positive cell line.…”
Section: Discussionmentioning
confidence: 99%
“…To date, seven alternatively spliced WWOX protein variants have been identified. The aberrant expression of WWOX has been reported in various cancer cell types including breast (2), ovarian (3), prostate (4), gastric (5) and hepatic cancer (6), osteosarcoma (7), and lung cancer (8).…”
Section: Introductionmentioning
confidence: 99%
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“…37,38 It was also shown that forced expression of WWOX could decrease FGF2-mediated proliferation and enhanced JNK inhibitorinduced apoptosis in human hepatocellular carcinoma cells. 39 Recent studies using human lung adenocarcinoma cell lines revealed that ectopic expression of WWOX could cause activation of procaspase-3 and caspase-9, and the release of cytochrome C thus leads to apoptosis. 40 P73, the p53 homolog, was also identified as the binding partner of WWOX through its PPxY motif in the C-terminal domain Tyrosin (Y) 33 in the first domain of WWOX was revealed as the target for phosphorylation by the Src kinase family and Src kinase mediated the phosphorylation of WWOX which enhances its interaction with p73.…”
Section: Wwox Tumor Suppressor's Functionmentioning
confidence: 99%