The JMJD Family Histone Demethylases in Crosstalk Between Inflammation and Cancer

Jia, Yang; Hu, Yuan; Zhang, Binjing; Liang, Xiao; Li, Xin

doi:10.3389/fimmu.2022.881396

Cited by 7 publications

(3 citation statements)

References 191 publications

(175 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The JmjC domain–containing enzymes can be divided into seven subfamilies (i.e., KDM2 to KDM8). This family is known to include 33 proteins in humans, of which 18 are reported to function as histone demethylases [ 54 , 55 ]. Target residues for the demethylation of histone include H3K4 (KDM5 family), H3K9 (KDM3 family), H3K27 (KDM6 family), H3K36 (KDM2 and KDM4 families), and H4K20 (KDM7 family).…”

Section: Inhibitors Of Jmjc Domain–containing Lysine Demethylasesmentioning

confidence: 99%

Chemical Inhibitors Targeting the Histone Lysine Demethylase Families with Potential for Drug Discovery

2023

View full text Add to dashboard Cite

The dynamic regulation of histone methylation and demethylation plays an important role in the regulation of gene expression. Aberrant expression of histone lysine demethylases has been implicated in various diseases including intractable cancers, and thus lysine demethylases serve as promising therapeutic targets. Recent studies in epigenomics and chemical biology have led to the development of a series of small-molecule demethylase inhibitors that are potent, specific, and have in vivo efficacy. In this review, we highlight emerging small-molecule inhibitors targeting the histone lysine demethylases and their progress toward drug discovery.

show abstract

Section: Inhibitors Of Jmjc Domain–containing Lysine Demethylasesmentioning

confidence: 99%

Chemical Inhibitors Targeting the Histone Lysine Demethylase Families with Potential for Drug Discovery

2023

View full text Add to dashboard Cite

show abstract

“…Histone demethylases do not change the DNA sequence, and dynamically regulate in specific chromatin regions. They are important regulators of the physiological functions of embryonic development, gene regulation, cell reprogramming and other physiological functions, and they maintain genome integrity and epigenetic stability ( 97 ). Their role in cancer is particularly important, and it is closely related to the pathogenesis of the disease, including the demethylation of the oncogenes/tumor suppressor genes for mastering the cell fate, the enrichment of transcription factors, gene copy number alterations, and increased mutations.…”

Section: Classification and Biological Functions Of Histone Methyltra...mentioning

confidence: 99%

The role of histone methylase and demethylase in antitumor immunity: A new direction for immunotherapy

Zhang

Chen²,

Liu³

et al. 2023

Front. Immunol.

View full text Add to dashboard Cite

Epigenetic modifications may alter the proliferation and differentiation of normal cells, leading to malignant transformation. They can also affect normal stimulation, activation, and abnormal function of immune cells in the tissue microenvironment. Histone methylation, coordinated by histone methylase and histone demethylase to stabilize transcription levels in the promoter area, is one of the most common types of epigenetic alteration, which gained increasing interest. It can modify gene transcription through chromatin structure and affect cell fate, at the transcriptome or protein level. According to recent research, histone methylation modification can regulate tumor and immune cells affecting anti-tumor immune response. Consequently, it is critical to have a thorough grasp of the role of methylation function in cancer treatment. In this review, we discussed recent data on the mechanisms of histone methylation on factors associated with immune resistance of tumor cells and regulation of immune cell function.

show abstract

“…Histone methylation refered to the process of transferring methyl from methionine to histone amino acids lysine (K) or arginine (R). Demethylation of different sites could lead to different effects, including the inhibition or activation of target genes [ 9 ]. Interestingly, abnormal histone demethylation levels are closely associated with various inflammatory diseases, including kidney injury, liver injury, and autoimmune diseases [ 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

Histone demethylases in the regulation of immunity and inflammation

Yin

Zhao

et al. 2023

Cell Death Discov.

View full text Add to dashboard Cite

Pathogens or danger signals trigger the immune response. Moderate immune response activation removes pathogens and avoids excessive inflammation and tissue damage. Histone demethylases (KDMs) regulate gene expression and play essential roles in numerous physiological processes by removing methyl groups from lysine residues on target proteins. Abnormal expression of KDMs is closely associated with the pathogenesis of various inflammatory diseases such as liver fibrosis, lung injury, and autoimmune diseases. Despite becoming exciting targets for diagnosing and treating these diseases, the role of these enzymes in the regulation of immune and inflammatory response is still unclear. Here, we review the underlying mechanisms through which KDMs regulate immune-related pathways and inflammatory responses. In addition, we also discuss the future applications of KDMs inhibitors in immune and inflammatory diseases.

show abstract

The JMJD Family Histone Demethylases in Crosstalk Between Inflammation and Cancer

Cited by 7 publications

References 191 publications

Chemical Inhibitors Targeting the Histone Lysine Demethylase Families with Potential for Drug Discovery

Chemical Inhibitors Targeting the Histone Lysine Demethylase Families with Potential for Drug Discovery

The role of histone methylase and demethylase in antitumor immunity: A new direction for immunotherapy

Histone demethylases in the regulation of immunity and inflammation

Contact Info

Product

Resources

About