The jet-like chromatin structure defines active secondary metabolism in fungi
Wenyong Shao,
Jingrui Wang,
Yueqi Zhang
et al.
Abstract:Eukaryotic genomes are spatially organized within the nucleus in a nonrandom manner. However, fungal genome arrangement and its function in development and adaptation remain largely unexplored. Here, we show that the high-order chromosome structure of Fusarium graminearum is sculpted by both H3K27me3 modification and ancient genome rearrangements. Active secondary metabolic gene clusters form a structure resembling chromatin jets. We demonstrate that these jet-like domains, which can propagate symmetrically fo… Show more
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