The Jellyfish Cassiopea Exhibits a Sleep-like State

Nath, Ravi D.; Bedbrook, Claire N.; Abrams, Michael J.; Basinger, Ty; Bois, Justin S.; Prober, David A.; Sternberg, Paul W.; Gradinaru, Viviana; Goentoro, Lea

doi:10.1016/j.cub.2017.08.014

Cited by 181 publications

(150 citation statements)

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“…In animals, the sleep–wake cycle is arguably the most conspicuous, ubiquitous, and important circadian rhythm. All animals—even simple animals, including jellyfish (Nath et al., ) and flatworms (Omond et al., )—sleep. Sleep can have important benefits for development and learning (Derégnaucourt, Mitra, Fehér, Pytte, & Tchernichovski, ; Kayser, Yue, & Sehgal, ), attention, motivation and emotional reactivity (Van Dongen, Maislin, Mullington, & Dinges, ), hand–eye coordination (Dawson & Reid, ), memory (Diekelmann & Born, ), immune function (Imeri & Opp, ), neurological waste clearance (Xie et al., ), and energy homeostasis (Schmidt, ; Schmidt, Swang, Hamilton, & Best, ).…”

Section: Introductionmentioning

confidence: 99%

Impacts of artificial light at night on sleep: A review and prospectus

et al. 2018

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Natural cycles of light and darkness govern the timing of most aspects of animal behavior and physiology. Artificial light at night (ALAN)-a recent and pervasive form of pollution-can mask natural photoperiodic cues and interfere with biological rhythms. One such rhythm vulnerable to perturbation is the sleep-wake cycle. ALAN may greatly influence sleep in humans and wildlife, particularly in animals that sleep predominantly at night. There has been some recent evidence for impacts of ALAN on sleep, but critical questions remain. Some of these can be addressed by adopting approaches already entrenched in sleep research. In this paper, we review the current evidence for impacts of ALAN on sleep, highlight gaps in our understanding, and suggest opportunities for future research.

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Section: Introductionmentioning

confidence: 99%

Impacts of artificial light at night on sleep: A review and prospectus

et al. 2018

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“…Animals ranging from jellyfish to humans display a homeostatic rebound following sleep deprivation [6,47]. Here we describe a functional and molecular mechanism underlying resilience to starvation-induced sleep loss.…”

Section: Discussionmentioning

confidence: 99%

Drosophila insulin-like peptide 2mediates dietary regulation of sleep intensity

Brown

Shah

Faville³

et al. 2019

Preprint

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18Sleep is a nearly universal behavior that is regulated by diverse environmental and physiological 19 stimuli. A defining feature of sleep is a homeostatic rebound following deprivation, where 20 animals compensate for lost sleep by increasing sleep duration and/or sleep depth. Fruit flies 21 exhibit robust recovery sleep following deprivation and represent a powerful model to study 22 neural circuits regulating sleep homeostasis. Numerous neuronal populations have been 23 identified in modulating sleep homeostasis as well as depth, raising the possibility that recovery 24 sleep is differentially regulated by environmental or physiological processes that induce sleep 25 deprivation. Here, we find that unlike most pharmacological and environmental manipulations 26 commonly used to restrict sleep, starvation potently induces sleep loss without a subsequent 27 rebound in sleep duration or depth. We find that both starvation and a sucrose-only diet result in 28 reduced metabolic rate and increased sleep depth, suggesting that dietary yeast protein is 29 essential for normal sleep depth and homeostasis. Finally, we find that Drosophila insulin like 30 peptide 2 (Dilp2) is required for starvation-induced changes in sleep depth without regulating the 31 duration of sleep. Remarkably, Dilp2 mutant flies require rebound sleep following sleep 32 deprivation, suggesting Dilp2 underlies resilience to sleep loss. Together, these findings reveal 33 innate resilience to starvation-induced sleep loss and identify distinct mechanisms that underlie 34 starvation-induced changes in sleep duration and depth.35 3 Author Summary 36 Sleep is nearly universal throughout the animal kingdom and homeostatic regulation represents 37 a defining feature of sleep, where animals compensate for lost sleep by increasing sleep over 38 subsequent time periods. Despite the robustness of this feature, surprisingly little is known 39 about how recovery-sleep is regulated in response to different types of sleep deprivation. Fruit 40 flies provide a powerful model for investigating the genetic regulation of sleep, and like 41 mammals, display robust recovery sleep following deprivation. Here, we find that unlike most 42 stimuli that suppress sleep, sleep deprivation by starvation does not require a homeostatic 43 rebound. These findings appear to be due to flies engaging in deeper sleep during the period of 44 partial deprivation, suggesting a natural resilience to starvation-induced sleep loss. This unique 45 resilience to starvation-induced sleep loss is dependent on Drosophila insulin-like peptide 2, 46 suggesting a critical role for insulin signaling in regulating interactions between diet and sleep 47 homeostasis. 48 4 Introduction 49Sleep is a near universal behavior that is modulated in accordance with internal and external 50 environments [1][2][3]. Numerous environmental factors can alter sleep including daily changes in 51 light and temperature, stress, social interactions, and nutrient availability [4,5]. A central factor 52 defining sleep i...

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“…Sleep is one example of a neural state that dramatically alters an animal's sensorimotor transformations [22,23]. Studies of sleep across the phylogenetic tree have shown that sensory systems transition to a reduced activity state that leads to a decreased animal response to external stimuli [24][25][26][27][28]. Additionally, sleep and wakefulness have been shown to correspond with distinct patterns of neural activity in humans [22,23], cats [29], rodents [23], and fruit flies [30,31].…”

Section: Introductionmentioning

confidence: 99%

Satiety, Thermosensation and Mechanosensation Regulate a Spontaneous C. elegans Sleep State

Gonzales

Zhou

2019

Preprint

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One remarkable feature of behavior is an animal's ability to rapidly switch between activity states such as locomotion and quiescence; however, how the brain regulates these spontaneous transitions based on the animal's perceived environment is not well understood. Here we show a C. elegans sleep-like state on a scalable platform that enables simultaneous control of multiple environmental factors including temperature, mechanical stress, and food availability. This brief quiescent state, we refer to as "μSleep," occurs spontaneously in microfluidic chambers, which allows us to track animal movement and perform whole-brain imaging. With these capabilities, we establish that μSleep meets the behavioral requirements of C. elegans sleep and depends on multiple external factors. Specifically, we show that μSleep is regulated by satiety and temperature, which is consistent with prior reports of C. elegans sleep. Additionally, we show for the first time that C. elegans sleep can be induced through mechanosensory pathways. Together, these results establish a rich model system for studying how animals process multiple sensory pathways to regulate behavioral states.

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The Jellyfish Cassiopea Exhibits a Sleep-like State

Cited by 181 publications

References 44 publications

Impacts of artificial light at night on sleep: A review and prospectus

Impacts of artificial light at night on sleep: A review and prospectus

Drosophila insulin-like peptide 2mediates dietary regulation of sleep intensity

Satiety, Thermosensation and Mechanosensation Regulate a Spontaneous C. elegans Sleep State

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