PURPOSE Twenty-four-hour ambulatory blood pressure (ABP) is the reference standard of blood pressure control. Home blood pressure (HBP) is superior to clinic blood pressure for assessing control, but a barrier to its use is the need for physicians to calculate average blood pressure from patient diaries. We sought to develop a quick and pragmatic method to assess blood pressure control from patients' HBP diaries.METHODS Seven-day HBP and 24-hour ABP were measured in 286 patients with uncomplicated treated hypertension (aged 64 ± 8 years; 53% female). We determined the optimal ratio of home systolic blood pressure readings above threshold (≥135 mm Hg) for the last 10 recorded that would best predict elevated 24-hour ABP. Uncontrolled blood pressure was defined as 24-hour ABP systolic blood pressure ≥130 mm Hg or 24-hour ABP daytime systolic blood pressure ≥135 mm Hg. Validation by corroborative evidence was tested by association with markers of end-organ disease.
RESULTSThe best predictor of 24-hour ABP systolic blood pressure above treatment/target threshold was having 3 or more (≥30%) of the last 10 home systolic blood pressure readings ≥135 mm Hg (area under the receiver operating characteristic curve = 0.71). Importantly, patients meeting this criterion had evidence of target organ disease, with significantly higher aortic stiffness, left ventricular relative wall thickness, and left atrial area, and lower left ventricular ejection fraction, compared with those who did not meet this criterion.CONCLUSIONS To facilitate uptake of HBP monitoring, we propose that physicians can determine the percentage of the last 10 home systolic blood pressure values ≥135 mm Hg for a patient and tailor management accordingly.
INTRODUCTIONC linic blood pressure is widely used for patient management, but the method has some limitations that may result in inaccurate assessment of true underlying blood pressure.1 Methods to assess out-of-clinic blood pressure using self-measured home blood pressure (HBP, the average blood pressure over 7 days) or 24-hour ambulatory blood pressure (ABP) have demonstrated superior prognostic utility with respect to target organ disease (eg, cardiac hypertrophy), 2-4 cardiovascular events, and cardiovascular and all-cause mortality.5-9 HBP has an advantage of already being in wide use, even if not in a standardized fashion. 10,11 It also helps to reduce health system costs, improve adherence to therapy, and achieve better blood pressure control.12-17 Accordingly, use of HBP as a tool to help guide management of high blood pressure is advocated in many countries. [18][19][20][21][22][23][24][25] A disadvantage of HBP is the requirement for manual calculation of the average of multiple values from patient diaries (eg, up to 28 recordings over 7 days) when using blood pressure devices that do not have storage memory, which currently predominate the market. If the patient has not calculated the average (which has its own reliability issue), the physician is James E. Sharman, BHMS (Hons)
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