The JAK1/JAK2 inhibitor ruxolitinib inhibits mediator release from human basophils and mast cells
Remo Poto,
Leonardo Cristinziano,
Gjada Criscuolo
et al.
Abstract:IntroductionThe Janus kinase (JAK) family includes four cytoplasmic tyrosine kinases (JAK1, JAK2, JAK3, and TYK2) constitutively bound to several cytokine receptors. JAKs phosphorylate downstream signal transducers and activators of transcription (STAT). JAK-STAT5 pathways play a critical role in basophil and mast cell activation. Previous studies have demonstrated that inhibitors of JAK-STAT pathway blocked the activation of mast cells and basophils.MethodsIn this study, we investigated the in vitro effects o… Show more
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