2001
DOI: 10.1002/bies.10016
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The JAK/STAT pathway and Drosophila development

Abstract: The JAK/STAT signal transduction pathway plays a critical role in mammalian cells, particularly in hematopoiesis and immune responses. Several components of this pathway have been identified and characterized in Drosophila. Mutational analyses of these components have revealed a number of interesting developmental roles, and provide a mechanism to identify other interacting molecules and pathways. Hence, the JAK/STAT pathway in Drosophila serves as an attractive model for in vivo functional analyses of JAK/STA… Show more

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Cited by 53 publications
(40 citation statements)
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References 69 publications
(86 reference statements)
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“…Melanotic tumors have previously been reported in a number of mutant backgrounds and are generally caused by neoplastic transformation of the larval blood cells. The circulating cells (hemocytes) of the larval blood or hemolymph provide one tier of the innate immune system of insects by encapsulating or engulfing pathogens (for review, see Immler and Hoffman 2001;Luo and Dearolf 2001;Tzou et al 2002). A number of mutations have been shown to trigger the overproliferation and premature differentiation of hemocytes.…”
Section: Mutations In Nurf Subunits Affect Hematopoietic Developmentmentioning
confidence: 99%
“…Melanotic tumors have previously been reported in a number of mutant backgrounds and are generally caused by neoplastic transformation of the larval blood cells. The circulating cells (hemocytes) of the larval blood or hemolymph provide one tier of the innate immune system of insects by encapsulating or engulfing pathogens (for review, see Immler and Hoffman 2001;Luo and Dearolf 2001;Tzou et al 2002). A number of mutations have been shown to trigger the overproliferation and premature differentiation of hemocytes.…”
Section: Mutations In Nurf Subunits Affect Hematopoietic Developmentmentioning
confidence: 99%
“…The Drosophila JAK/STAT signaling pathway is composed of several major factors: the three ligands Unpaired (Upd) (Harrison et al, 1998), Upd2 (Gilbert et al, 2005;Hombria et al, 2005) and Upd3 (Agaisse et al, 2003); the transmembrane receptor Domeless (Dome) (Brown et al, 2001;Chen et al, 2002); the JAK homolog Hopscotch (Hop) (Binari and Perrimon, 1994); and the STAT homolog Stat92E (Hou et al, 1996;Yan et al, 1996). JAK/STAT signaling is involved in many developmental processes, including segmentation in embryogenesis, eye morphogenesis, hematopoiesis and stem cell maintenance (Arbouzova and Zeidler, 2006;Luo and Dearolf, 2001;Zeidler et al, 2000). Here, we report a novel mechanism underlying NB (neural progenitor) formation and discuss its role in establishing a precise topographic map in the visual system.…”
Section: Introductionmentioning
confidence: 99%
“…The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) cascade is a signal transduction pathway that was originally identified in the vertebrate system [1,2] and has been extensively studied during the last decade in several model organisms, including Drosophila [1,3,4,5]. This pathway was identified through studies on the transcriptional activation response to a variety of cytokines and growth factors [6,7] and is highly conserved and capable of transmitting a multitude of signals for development and homeostasis in animals from flies to humans.…”
Section: Introductionmentioning
confidence: 99%