The JAK/STAT pathway and <i>Drosophila</i> development

Luo, Hong; Dearolf, Charles R.

doi:10.1002/bies.10016

Cited by 53 publications

(40 citation statements)

References 69 publications

(86 reference statements)

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“…Melanotic tumors have previously been reported in a number of mutant backgrounds and are generally caused by neoplastic transformation of the larval blood cells. The circulating cells (hemocytes) of the larval blood or hemolymph provide one tier of the innate immune system of insects by encapsulating or engulfing pathogens (for review, see Immler and Hoffman 2001;Luo and Dearolf 2001;Tzou et al 2002). A number of mutations have been shown to trigger the overproliferation and premature differentiation of hemocytes.…”

Section: Mutations In Nurf Subunits Affect Hematopoietic Developmentmentioning

confidence: 99%

Biological functions of the ISWI chromatin remodeling complex NURF

Badenhorst

Voas²,

Rebay³

et al. 2002

Genes Dev.

211

203

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The nucleosome remodeling factor (NURF) is one of several ISWI-containing protein complexes that catalyze ATP-dependent nucleosome sliding and facilitate transcription of chromatin in vitro. To establish the physiological requirements of NURF, and to distinguish NURF genetically from other ISWI-containing complexes, we isolated mutations in the gene encoding the large NURF subunit, nurf301. We confirm that NURF is required for transcription activation in vivo. In animals lacking NURF301, heat-shock transcription factor binding to and transcription of the hsp70 and hsp26 genes are impaired. Additionally, we show that NURF is required for homeotic gene expression. Consistent with this, nurf301 mutants recapitulate the phenotypes of Enhancer of bithorax, a positive regulator of the Bithorax-Complex previously localized to the same genetic interval. Finally, mutants in NURF subunits exhibit neoplastic transformation of larval blood cells that causes melanotic tumors to form.

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Section: Mutations In Nurf Subunits Affect Hematopoietic Developmentmentioning

confidence: 99%

Biological functions of the ISWI chromatin remodeling complex NURF

Badenhorst

Voas²,

Rebay³

et al. 2002

Genes Dev.

211

203

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“…The Drosophila JAK/STAT signaling pathway is composed of several major factors: the three ligands Unpaired (Upd) (Harrison et al, 1998), Upd2 (Gilbert et al, 2005;Hombria et al, 2005) and Upd3 (Agaisse et al, 2003); the transmembrane receptor Domeless (Dome) (Brown et al, 2001;Chen et al, 2002); the JAK homolog Hopscotch (Hop) (Binari and Perrimon, 1994); and the STAT homolog Stat92E (Hou et al, 1996;Yan et al, 1996). JAK/STAT signaling is involved in many developmental processes, including segmentation in embryogenesis, eye morphogenesis, hematopoiesis and stem cell maintenance (Arbouzova and Zeidler, 2006;Luo and Dearolf, 2001;Zeidler et al, 2000). Here, we report a novel mechanism underlying NB (neural progenitor) formation and discuss its role in establishing a precise topographic map in the visual system.…”

Section: Introductionmentioning

confidence: 99%

Drosophilaoptic lobe neuroblasts triggered by a wave of proneural gene expression that is negatively regulated by JAK/STAT

et al. 2008

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Neural stem cells called neuroblasts (NBs) generate a variety of neuronal and glial cells in the central nervous system of the Drosophila embryo. These NBs, few in number, are selected from a field of neuroepithelial (NE) cells. In the optic lobe of the third instar larva, all NE cells of the outer optic anlage (OOA) develop into either NBs that generate the medulla neurons or lamina neuron precursors of the adult visual system. The number of lamina and medulla neurons must be precisely regulated because photoreceptor neurons project their axons directly to corresponding lamina or medulla neurons. Here, we show that expression of the proneural protein Lethal of scute [L(1)sc] signals the transition of NE cells to NBs in the OOA. L(1)sc expression is transient, progressing in a synchronized and ordered 'proneural wave' that sweeps toward more lateral NEs. l(1)sc expression is sufficient to induce NBs and is necessary for timely onset of NB differentiation. Thus, proneural wave precedes and induces transition of NE cells to NBs. Unpaired (Upd), the ligand for the JAK/STAT signaling pathway, is expressed in the most lateral NE cells. JAK/STAT signaling negatively regulates proneural wave progression and controls the number of NBs in the optic lobe. Our findings suggest that NBs might be balanced with the number of lamina neurons by JAK/STAT regulation of proneural wave progression, thereby providing the developmental basis for the formation of a precise topographic map in the visual center.

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“…The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) cascade is a signal transduction pathway that was originally identified in the vertebrate system [1,2] and has been extensively studied during the last decade in several model organisms, including Drosophila [1,3,4,5]. This pathway was identified through studies on the transcriptional activation response to a variety of cytokines and growth factors [6,7] and is highly conserved and capable of transmitting a multitude of signals for development and homeostasis in animals from flies to humans.…”

Section: Introductionmentioning

confidence: 99%

JAK/STAT signaling regulates tissue outgrowth and male germline stem cell fate in Drosophila

2005

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In multicellular organisms, biological activities are regulated by cell signaling. The various signal transduction pathways regulate cell fate, proliferation, migration, and polarity. Miscoordination of the communicative signals will lead to disasters like cancer and other fatal diseases. The JAK/STAT signal transduction pathway is one of the pathways, which was first identified in vertebrates and is highly conserved throughout evolution. Studying the JAK/STAT signal transduction pathway in Drosophila provides an excellent opportunity to understand the molecular mechanism of the cell regulation during development and tumor formation. In this review, we discuss the general overview of JAK/STAT signaling in Drosophila with respect to its functions in the eye development and stem cell fate determination.

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The JAK/STAT pathway and Drosophila development

Cited by 53 publications

References 69 publications

Biological functions of the ISWI chromatin remodeling complex NURF

Biological functions of the ISWI chromatin remodeling complex NURF

Drosophilaoptic lobe neuroblasts triggered by a wave of proneural gene expression that is negatively regulated by JAK/STAT

JAK/STAT signaling regulates tissue outgrowth and male germline stem cell fate in Drosophila

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