The IVAIRE project - a randomized controlled study of the impact of ventilation on indoor air quality and the respiratory symptoms of asthmatic children in single family homes

Lajoie, Pierre; Aubin, Daniel; Gingras, Véronique; Daigneault, Patrick; Ducharme, Francine M; Gauvin, Denis; Fugler, Don; Leclerc, Jean-Marc; Won, Doyun; Courteau, Marilène; Gingras, Suzanne; Héroux, Marie Eve; Yang, Wenjing; Schleibinger, Hans

doi:10.1111/ina.12181

Cited by 32 publications

(22 citation statements)

References 41 publications

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“…One of these studies estimated that VRs increased by 0.18 L/s with added MV; however, indoor CO 2 concentrations decreased by only 16%, compared to a 9% decrease in control homes. In the second of these studies, the VR increased by 0.17 h −1 in intervention homes compared to a 0.03 h −1 increase in control homes.…”

Section: Resultsmentioning

confidence: 97%

“…Overall, 11 of 20 studies reported a SS improvement in one or more health outcomes with increased VRs or with lower CO 2 concentrations that indicate higher VRs. Most of these studies included assessments of multiple additional health outcomes that were not statistically significantly associated with VRs.…”

Section: Resultsmentioning

confidence: 99%

“…In seven of eight intervention studies, the health effects of occupants of homes were assessed before and after, or with and without, adding a mechanical ventilation (MV) system . One intervention study assessed health effects before and after small reductions in the rates of ventilation provided by preexisting MV systems.…”

Section: Resultsmentioning

confidence: 99%

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How home ventilation rates affect health: A literature review

Fisk

2018

Indoor Air

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This paper reviews studies of the relationships between ventilation rates (VRs) in homes and occupant health, primarily respiratory health. Five cross-sectional studies, seven case-control studies, and eight intervention studies met inclusion criteria. Nearly all studies controlled for a range of potential confounders and most intervention studies included placebo conditions. Just over half of studies reported one or more statistically significant (SS) health benefits of increased VRs. Wheeze was most clearly associated with VR. No health outcomes had SS associations with VRs in the majority of statistical tests. Most studies that reported SS health benefits from increased VRs also had additional health outcomes that did not improve with increased VRs. Overall, the number of SS improvements in health with increased VRs exceeded the anticipated chance improvements by approximately a factor of seven. The magnitude of the improvements in health outcomes with increased VRs ranged from 20% to several-fold improvements. In summary, the available research indicates a tendency for improvements in respiratory health with increased home VRs; however, health benefits do not occur consistently and other exposure control measures should be used together with ventilation. The research did not enable identification of a threshold VR below which adverse health effects occur.

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Section: Resultsmentioning

confidence: 97%

Section: Resultsmentioning

confidence: 99%

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How home ventilation rates affect health: A literature review

Fisk

2018

Indoor Air

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“…Bisher ist in der Literatur nur eine Interventionsstudie im Kindesalter publiziert, die auch Messungen der Formaldehyd-Konzentration in der Innenraumluft umfasste [3]. In ihr wurden 83 asthmatische Kinder im Alter von 3-12 Jahren, die in schlecht belüfteten Wohnräumen (Lüftungsra-ten unter 0,3 h -1 , im Mittel 0,18 h -1 ) lebten, über 2 Jahre verfolgt.…”

Section: Interventionsstudienunclassified

“…In gesundheitlicher Hinsicht wurden bei der primären Zielvariablen "Anzahl der Tage mit Symptomen" keine Unterschiede zwischen den Gruppen beobachtet. Aber in der Interventionsgruppe wurde eine verminderte Häufigkeit folgender sekundä-rer Zielvariablen gefunden: mindestens eine Wheezing-Episode im Jahr zu ha-m 3 …”

Section: Interventionsstudienunclassified

Zur Frage eines Asthma auslösenden bzw. verschlechternden Potenzials von Formaldehyd in der Innenraumluft bei Kindern

2016

Bundesgesundheitsbl

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EinleitungAls Hauptwirkung eingeatmeten Formaldehyds wird allgemein die Reizwirkung auf den oberen Atemtrakt angesehen. Bei chronischer Einwirkung können sehr hohe Formaldehyd-Konzentrationen zytotoxische und kanzerogene Wirkungen in diesem Gewebe nach sich ziehen [1]. Während bei Ratten Formaldehyd fast ausschließlich in der Nase resorbiert wird (zu 99 % bei 0,1-1 mg/m 3 ), wird es nach Modellabschätzungen im gleichen Konzentrationsbereich bei Primaten und Menschen nur zu 87 % bzw. zu 85 % in der Nase, aber zu einem geringen Anteil auch im oberen Atemtrakt (Rachen, Luftröhre und Bronchien) aufgenommen [2].

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