The IUPS human physiome project

Abstract

The Physiome Project of the International Union of Physiological Sciences (IUPS) is attempting to provide a comprehensive framework for modelling the human body using computational methods which can incorporate the biochemistry, biophysics and anatomy of cells, tissues and organs. A major goal of the project is to use computational modelling to analyse integrative biological function in terms of underlying structure and molecular mechanisms. To support that goal the project is establishing web-accessible physiological databases dealing with model-related data, including bibliographic information, at the cell, tissue, organ and organ system levels. Here we discuss the background and goals of the project, the problems of modelling across multiple spatial and temporal scales, and the development of model ontologies and markup languages at all levels of biological function.

Modeling Biology in Modelica: The Human Baroreflex

“…Recent support comes in form of mathematical models, forming the field of systems biology. A strong mathematical foundation can help where intuition fails and indeed there are now projects such as the Virtual Liver Network (Holzhütter et al, 2012), the Blue Brain Project (Markram, 2006) or the Physiome Project (Hunter et al, 2002) that are on the way of building comprehensive multi-scale models for complete human organs.…”

Modular Modeling of Biological Systems

“…It is supported by International Union of Physiological Sciences Physiome Project [Hunter et al, 2002] and EuroPhysiome initiative [Fenner et al, 2008] coordinating the efforts of many research groups around the world. One of its major challenges is models integration and coupling [Fenner et al, 2008].…”

A Mathematical Model for Evolution of Human Functional Disorders Influenced by Environment Factors

“…В качестве информационного ресурса для таких работ выступает международный проект Physiome [21,22], содержащий работы, ориентированные на математическое моделирование физиологических процессов. Главной целью проекта является разработка модели человеческого организма, с использованием методов, объединяющих биохимию, биофизику и анатомию клеток, тканей и органов.…”