The Itel-MMSE: an Italian telephone version of the Mini-Mental State Examination

Metitieri, Tiziana; Geroldi, Cristina; Pezzini, Alessandra; Frisoni, Giovanni B.; Bianchetti, Angelo; Trabucchi, Marco

doi:10.1002/1099-1166(200102)16:2<166::aid-gps290>3.0.co;2-m

Cited by 47 publications

(36 citation statements)

References 4 publications

(5 reference statements)

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“…mRS is largely determined by motor performance, hence the need for the presence of motor symptoms and signs at enrolment. Prespecified secondary outcomes at day 90 included activities of daily living (Barthel index); 31 cognition (modified telephone mini-mental state examination 32 and telephone interview for cognition scale 33 ); health-related quality of life (European quality of life-5 dimensions, EQ-5D, 34 from which health utility status was calculated [EQ-5D-HUS]); and mood (short Zung depression score 35 ). 36 At discharge from initial admittance to hospital, investigators recorded duration of stay, and discharge destination (to institution or home).…”

Section: Methodsmentioning

confidence: 99%

Efficacy of nitric oxide, with or without continuing antihypertensive treatment, for management of high blood pressure in acute stroke (ENOS): a partial-factorial randomised controlled trial

2015

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SummaryBackgroundHigh blood pressure is associated with poor outcome after stroke. Whether blood pressure should be lowered early after stroke, and whether to continue or temporarily withdraw existing antihypertensive drugs, is not known. We assessed outcomes after stroke in patients given drugs to lower their blood pressure.MethodsIn our multicentre, partial-factorial trial, we randomly assigned patients admitted to hospital with an acute ischaemic or haemorrhagic stroke and raised systolic blood pressure (systolic 140–220 mm Hg) to 7 days of transdermal glyceryl trinitrate (5 mg per day), started within 48 h of stroke onset, or to no glyceryl trinitrate (control group). A subset of patients who were taking antihypertensive drugs before their stroke were also randomly assigned to continue or stop taking these drugs. The primary outcome was function, assessed with the modified Rankin Scale at 90 days by observers masked to treatment assignment. This study is registered, number ISRCTN99414122.FindingsBetween July 20, 2001, and Oct 14, 2013, we enrolled 4011 patients. Mean blood pressure was 167 (SD 19) mm Hg/90 (13) mm Hg at baseline (median 26 h [16–37] after stroke onset), and was significantly reduced on day 1 in 2000 patients allocated to glyceryl trinitrate compared with 2011 controls (difference −7·0 [95% CI −8·5 to −5·6] mm Hg/–3·5 [–4·4 to −2·6] mm Hg; both p<0·0001), and on day 7 in 1053 patients allocated to continue antihypertensive drugs compared with 1044 patients randomised to stop them (difference −9·5 [95% CI −11·8 to −7·2] mm Hg/–5·0 [–6·4 to −3·7] mm Hg; both p<0·0001). Functional outcome at day 90 did not differ in either treatment comparison—the adjusted common odds ratio (OR) for worse outcome with glyceryl trinitrate versus no glyceryl trinitrate was 1·01 (95% CI 0·91–1·13; p=0·83), and with continue versus stop antihypertensive drugs OR was 1·05 (0·90–1·22; p=0·55).InterpretationIn patients with acute stroke and high blood pressure, transdermal glyceryl trinitrate lowered blood pressure and had acceptable safety but did not improve functional outcome. We show no evidence to support continuing prestroke antihypertensive drugs in patients in the first few days after acute stroke.FundingUK Medical Research Council.

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Section: Methodsmentioning

confidence: 99%

Efficacy of nitric oxide, with or without continuing antihypertensive treatment, for management of high blood pressure in acute stroke (ENOS): a partial-factorial randomised controlled trial

2015

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“…(2) Cognitive status was assessed through a phone version of the Mini Mental State Examination (Itel-MMSE) ( 35 ). Itel-MMSE is a validated Italian tool which shows strong correlations with paper-and-pencil MMSE ( r = 0.85 in the whole sample and r = 0.77 in MCI subjects) ( 36 ) and it is predictive of domain-specific cognitive test performances ( 37 ).…”

Section: Methodsmentioning

confidence: 99%

The Effects of COVID-19 and Quarantine Measures on the Lifestyles and Mental Health of People Over 60 at Increased Risk of Dementia

et al. 2020

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Background: The lockdown strategies adopted to limit the spread of COVID-19 infection may lead to adopt unhealthy lifestyles which may impact on the mental well-being and future risk of dementia. Older adults with mild cognitive impairment (MCI) or subjective cognitive decline (SCD) may suffer important mental health consequences from measures of quarantine and confinement. Aims: The study aimed to explore the effects of COVID-19 and quarantine measures on lifestyles and mental health of elderly at increased risk of dementia. Methods: One hundred and twenty six community-dwelling seniors with MCI or SCD were phone-interviewed and assessed with questions regarding variables related to COVID-19 pandemic, lifestyle changes and scales validated for the assessment of depression, anxiety, and apathy. Results: The sample included 55.6% patients with MCI and 56 people with SCD. Over 1/3 of the sample reduced their physical activity and nearly 70% reported an increase in idle time. Adherence to the Mediterranean diet decreased in almost 1/3 of respondents and over 35% reported weight gain. Social activities were abolished and 1/6 of participants also decreased productive and mental-stimulating activities. 19.8% were depressed, 9.5% anxious, and 9.5% apathetic. A significant association existed between depression and living alone or having a poor relation with cohabitants and between anxiety and SCD, cold or flu symptoms, and reduction in productive leisure activities. Conclusions: Seniors with SCD and MCI underwent lifestyle changes that are potentially harmful to their future cognitive decline, even if, with the exception of leisure activities, they do not appear to be cross-sectionally associated with psychiatric symptoms.

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“…Inclusion criteria included: (i) age > 18 years, (ii) mini mental state examination (MMSE) score > 26 (in person (Folstein et al, 1975) or telephone version (Metitieri et al, 2001)) or a score equal to 0 at the Clinical Dementia Rating Scale (CDR), (iii) availability of 3D T1-weighted MR images with no artifacts affecting atrophy assessment with MTA and PA scales. As exclusion criteria, we considered: developmental cognitive disorders, learning disabilities, diagnosis of a psychiatric disease and evidence of any major neurological disease (brain mass, white matter hyperintensities in patients undergoing MRI for suspected multiple sclerosis or suspected ischemic lesions, aneurysm larger than 10 mm, arteriovenous malformation besides developmental venous anomalies, congenital malformations of the central nervous system) after radiological assessment.…”

Section: Methodsmentioning

confidence: 99%

Medial temporal lobe atrophy and posterior atrophy scales normative values

Ramusino

Altomare

Bacchin

et al. 2019

NeuroImage: Clinical

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Objectives The medial temporal lobe atrophy (MTA) and the posterior atrophy (PA) scales allow to assess the degree hippocampal and parietal atrophy from magnetic resonance imaging (MRI) scans. Despite reliable, easy and widespread employment, appropriate normative values are still missing. We aim to provide norms for the Italian population. Methods Two independent raters assigned the highest MTA and PA score between hemispheres, based on 3D T1-weighted MRI of 936 Italian Brain Normative Archive subjects (age: mean ± SD: 50.2 ± 14.7, range: 20–84; MMSE>26 or CDR = 0). The inter-rater agreement was assessed with the absolute intraclass correlation coefficient (aICC). We assessed the association between MTA and PA scores and sociodemographic features and APOE status, and normative data were established by age decade based on percentile distributions. Results Raters agreed in 90% of cases for MTA (aICC = 0.86; 95% CI = 0.69–0.98) and in 86% for PA (aICC = 0.82; 95% CI = 0.58–0.98). For both rating scales, score distribution was skewed, with MTA = 0 in 38% of the population and PA = 0 in 52%, while a score ≥ 2 was only observed in 12% for MTA and in 10% for PA. Median denoted overall hippocampal (MTA: median = 1, IQR = 0–1) and parietal (PA: median = 0, IQR = 0–1) integrity. The 90th percentile of the age-specific distributions increased from 1 (at age 20–59) for both scales, to 2 for PA over age 60, and up to 4 for MTA over age 80. Gender, education and APOE status did not significantly affect the percentile distributions in the whole sample, nor in the subset over age 60. Conclusions Our normative data for the MTA and PA scales are consistent with previous studies and overcome their main limitations (in particular uneven representation of ages and missing percentile distributions), defining the age-specific norms to be considered for proper brain atrophy assessment.

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The Itel-MMSE: an Italian telephone version of the Mini-Mental State Examination

Cited by 47 publications

References 4 publications

Efficacy of nitric oxide, with or without continuing antihypertensive treatment, for management of high blood pressure in acute stroke (ENOS): a partial-factorial randomised controlled trial

Efficacy of nitric oxide, with or without continuing antihypertensive treatment, for management of high blood pressure in acute stroke (ENOS): a partial-factorial randomised controlled trial

The Effects of COVID-19 and Quarantine Measures on the Lifestyles and Mental Health of People Over 60 at Increased Risk of Dementia

Medial temporal lobe atrophy and posterior atrophy scales normative values

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