The Italian Program for Surveillance of Acute Plant Protection Pesticide-Related Poisoning

Settimi, Laura; Davanzo, Franca; Cossa, Loide; Urbani, Elisabetta; Giordano, F

doi:10.1093/eurpub/ckv175.140

Cited by 2 publications

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“…Even though two-thirds of the 350,000 annual pesticide-related deaths occur in developing countries, figures remain of significant relevance also for high income countries [ 10 , 11 ]. In Italy, for example, a total of around 2,500 occupational cases of acute pesticide intoxications were identified between 2005 and 2011, representing 5% of all poisonings [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Health and Safety of Pesticide Applicators in a high income agricultural setting: a knowledge, attitude, practice, and toxicity study from North-Eastern Italy

Riccò

Vezzosi

Gualerzi

2018

Journal of Preventive Medicine and Hygiene

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Section: Introductionmentioning

confidence: 99%

Health and Safety of Pesticide Applicators in a high income agricultural setting: a knowledge, attitude, practice, and toxicity study from North-Eastern Italy

Riccò

Vezzosi

Gualerzi

2018

Journal of Preventive Medicine and Hygiene

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“…Dormex ® 's precise mode of toxicity is unknown. However, many studies suggested that Dormex ® causes oxidative stress and uncoupling of oxidative phosphorylation [6]. Oxidative stress has been identified as a factor that can cause damage to several organs, including the liver, kidney, and lungs, as well as the central nervous system, cardiovascular system, and hemopoietic system [7].…”

Section: Introductionmentioning

confidence: 99%

Hepatotoxic Effect of Hydrogen Cyanamide (Dormex®) in Albino Rats and the Ameliorative Effect of Melatonin

Mohammed,

Salah El Sayed

2024

IJMTFM

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Background: Hydrogen cyanamide (Dormex®) is used as a fertilizer sprayed on fruits, especially grapes to stimulate buds’ opening. It causes oxidative stress leading to hepatic, renal, and lung damage. Melatonin is derived primarily from the amino acid tryptophan, produced from the pineal gland, and has antioxidant effects. This study aimed to examine the effects of acute hydrogen cyanamide (Dormex®) exposure on the liver of albino rats and evaluate the biochemical and histological changes caused by Dormex® toxicity. Additionally, the study evaluated the potential ameliorative role of melatonin in these harmful effects. Methods: Forty adult male albino rats were divided into four groups; group I: Negative control, group II: Melatonin-treated (100 mg/kg/day), group III: Dormex®-treated (100 mg/kg) as a single dose, and group IV: Receiving melatonin (100 mg/kg/day)+Dormex® (100 mg/kg). After 24 hours, all animals were evaluated for liver enzymes (alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, and bilirubin), hepatic markers for oxidative stress (malondialdehyde (MDA), reduced glutathione (GSH), and superoxide dismutase (SOD)) and histopathological examination was done for hepatic tissues. Results: The Dormex®-treated group showed significantly elevated liver enzymes, elevated MDA, and decreased GSH and SOD. Histopathological examination revealed normal structure in groups 1 and 2 while group 3 showed several histopathological changes characterized by inflammation and hepatic necrosis. Administration of melatonin with Dormex® in group 4 caused a decrease in liver enzymes and MDA and an increase in GSH and SOD with improvement in liver histopathology. Conclusion: Melatonin showed an ameliorative effect and can be used as a protective agent against Dormex®-induced hepatic injury.

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The Italian Program for Surveillance of Acute Plant Protection Pesticide-Related Poisoning

Cited by 2 publications

References 0 publications

Health and Safety of Pesticide Applicators in a high income agricultural setting: a knowledge, attitude, practice, and toxicity study from North-Eastern Italy

Health and Safety of Pesticide Applicators in a high income agricultural setting: a knowledge, attitude, practice, and toxicity study from North-Eastern Italy

Hepatotoxic Effect of Hydrogen Cyanamide (Dormex®) in Albino Rats and the Ameliorative Effect of Melatonin

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