The Italian Multiorgan Donor Cancer Screening Protocol: 2002–2005 Experience

Abstract

Implementation of the multiorgan cancer screening protocol is feasible at a national level in Italy. In view of the increasing demand for organs our protocol provides a useful tool for rationalization of the use of organs from neoplastic marginal donors.

Organ transplantation from donors (cadaveric or living) with a history of malignancy: Review of the literature

“…Another report from Italy found a similar overall cancer transmission rate of 0.2% (14 of 231) in transplant recipients from donors with malignancy [7], while the Spanish National Transplant Organization Registry reported transmission of malignancy in 10 of the 100 (10%) cases of transplants performed using donors with known malignancy. The transmission rates were supposed to be 6 per 10,000 related to the global recipients [8].…”

Donor-Transmitted Malignancies in Organ Transplantation: Assessment of Clinical Risk

“…Interpretation of data regarding cancer in this setting is further complicated by the fact that reports to transplant cancer registries may overestimate transmission, whereas underreporting, at least historically, may be more likely in the general OPTN database. Previous efforts by the Spanish National Transplant Organization (15) and Italian National Transplant Centre (16) have been published.…”

Rapid screening for malignancy in organ donors: 15‐year experience with the Verona “Alert” protocol and review of the literature

“…The definition of risk categories regarding infectious, neoplastic and other transmittable diseases. [5][6][7][8] There are five risk categories: 1) Unacceptable risk: donor excluded from donation 2) Increased but acceptable risk: transplantation is allowed by urgency or by special clinical conditions of recipients 3) Calculated risk: transplantation is allowed for recipients with the same transmittable disease or with a protective serologic status 4) Not assessable risk: the evaluation process does not allow an appropriate risk assessment 5) Standard risk: any transmittable disease identified…”