2022
DOI: 10.1021/acsnano.2c09249
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The Issue of Reliability and Repeatability of Analytical Measurement in Industrial and Academic Nanomedicine

Abstract: The issue of reliability and repeatability of data in the nanomedicine literature is a growing concern among stakeholders. This perspective discusses the key differences between academia and industry in the reproducibility of data acquisition and protocols in the field of nanomedicine. We also discuss what academic researchers can learn from systems implemented in industry to standardize data acquisition and in which ways these can be efficiently adopted by the academic community.

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Cited by 13 publications
(9 citation statements)
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References 27 publications
(50 reference statements)
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“…353 To achieve clinical translation, extensive attention should be paid to data sharing, establishing reliability/repeatability or broad standards for data, which saves time, reduces costs, streamlines processes, and enables the sharing of creative resources. 366 By making experimental designs and methods digitally accessible and reproducible, they are easily documented and viewable and fully transferable to others. For instance, the National Cancer Institute's (NCI) caNanoLab offers implications for future nano-cancer research.…”
Section: Main Challengementioning
confidence: 99%
“…353 To achieve clinical translation, extensive attention should be paid to data sharing, establishing reliability/repeatability or broad standards for data, which saves time, reduces costs, streamlines processes, and enables the sharing of creative resources. 366 By making experimental designs and methods digitally accessible and reproducible, they are easily documented and viewable and fully transferable to others. For instance, the National Cancer Institute's (NCI) caNanoLab offers implications for future nano-cancer research.…”
Section: Main Challengementioning
confidence: 99%
“…Moreover, the clinical translation of nanomedicine in cancer diagnosis and treatment is hindered by the lack of a deep understanding of the biological identity of nanomedicines 86 as well as several regulatory and logistical challenges. 87 The development of nanoparticles involves complex manufacturing processes and requires the development and use of standardized strategies, 88,89 along with extensive preclinical and clinical evaluations to ensure safety and efficacy. Furthermore, the regulatory and ethical considerations related to the use of nanoparticles in humans need to be carefully evaluated and addressed.…”
Section: ■ Conclusion and Perspectivesmentioning
confidence: 99%
“…Increasingly, researchers advocate for the use of refined models to bridge the in vitro -in vivo gap, [1] that can reproduce physiological conditions and generate reliable and reproducible long-term measurements under standard laboratory conditions. [2] DOI: 10.1002/adfm. 202310078 The interaction of nanoparticles with a complex and dynamic microenvironment such as a physiological barrier is affected by multiple nanoparticle-specific factors, including size, chemical composition, surface charge, morphology, and delivery protocol.…”
Section: Introductionmentioning
confidence: 99%