The Israeli public health response to wild poliovirus importation

Kaliner, Ehud; Kopel, Eran; Anis, Emilia; Mendelson, Ella; Moran-Gilad, Jacob; Shulman, Lester M.; Singer, Shepherd Roee; Manor, Yossi; Somekh, Eli; Rishpon, Shmuel; Leventhal, Alex; Rubin, Lisa; Tasher, Diana; Honovich, Mira; Moerman, Larisa; Shohat, Tamy; Bassal, Ravit; Sofer, Danit; Gdalevich, Michael; Lev, Baruch; Gamzu, Ronni; Grotto, Itamar

doi:10.1016/s1473-3099(15)00064-x

Cited by 47 publications

(52 citation statements)

References 26 publications

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“…The immunity level against poliovirus type 1 was determined by retrospective analysis of sera obtained from 104 children (6e7 years old scheduled to receive an IPV booster), and from serum samples of a nationally representative sample of 400 individuals in a prospective fashion. Seroprotective level of neutralizing antibodies against WPV1 was confirmed for 100% and 98.2% of the participants, respectively [15].…”

Section: Assessment Of Protectionmentioning

confidence: 88%

Public health response to the silent reintroduction of wild poliovirus to Israel, 2013–2014

Moran-Gilad

Kaliner

Gdalevich

et al. 2016

Clinical Microbiology and Infection

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During 2013/14, Israel witnessed the silent reintroduction and sustained transmission of wild poliovirus type 1 (WPV1) detected through routine environmental surveillance performed on sewage samples. The public health response to silent poliovirus transmission in a population with high inactivated polio vaccine (IPV) coverage poses an emerging challenge towards the 'End Game' of global poliovirus eradication. This paper reviews the risk assessment, risk management and risk communication aspects of this poliovirus incident. Special emphasis is placed on the use of scientific data generated in the risk assessment phase to inform the public health response. Reintroducing a live vaccine in supplemental immunization activities in response to transmission of WPV or vaccine-derived poliovirus should be considered close to the 'End Game' of polio eradication, especially if targeting the population at risk is feasible. Such circumstances require a comprehensive contingency plan that will support the generation of important public health evidence at the risk assessment stage, thereby allowing to tailor the risk management approaches and underpin appropriate risk communication.

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Section: Assessment Of Protectionmentioning

confidence: 88%

Public health response to the silent reintroduction of wild poliovirus to Israel, 2013–2014

Moran-Gilad

Kaliner

Gdalevich

et al. 2016

Clinical Microbiology and Infection

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“…Recently, wastewater-based epidemiology was used as an early indicator of poliovirus outbreaks to target vaccination campaigns (Manor 2014, Kaliner 2015, to monitor asymptomatic virus circulation (Berchenko 2017), and as a novel source of data on illicit drug consumption in Australia (Australian Report) and over 60 European cities and towns (van Nuijs 2018, Thomas 2012, Baz-Lomba 2016. More recently, wastewater analysis has been proposed as a promising tool to tackle the severe opioid epidemic in the U.S. and Canada (Keshaviah 2016, Keshaviah 2017 as well as to monitor antimicrobial resistance (Pehrsson 2017, Initiatives 2018, obesity levels, and lifestyle biomarkers (Daughton 2018, Arnaud 2018, Newton 2015.…”

Section: Introductionmentioning

confidence: 99%

24-hour multi-omics analysis of residential sewage reflects human activity and informs public health

Matus¹,

Duvallet

Soule

et al. 2019

Preprint

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High-throughput molecular analysis of sewage is a promising tool for precision public health. Here, we combine sewer network and demographic data to identify a residential catchment for sampling, and explore the potential of applying untargeted genomics and metabolomics to sewage to collect actionable public health data. We find that wastewater sampled upstream in a residential catchment is representative of the human microbiome and metabolome, and we are able to identify glucuronidated compounds indicative of direct human excretion, which are typically degraded too quickly to be detected at treatment plants. We show that diurnal variations during 24-hour sampling can be leveraged to discriminate between biomarkers in sewage that are associated with human activity from those related to the environmental background. Finally, we putatively annotate a suite of human-associated metabolites, including pharmaceuticals, food metabolites, and biomarkers of human health and activity, suggesting that mining untargeted data derived from residential sewage can expand currently-used biomarkers with direct public health or policy relevance. process sewage non-stop through one day, and for Herbie from Cambridge Public Works for providing his good humor and professional insights during our many sampling trips. We thank the generous sponsorship of the Kuwait Foundation for Advancement of Sciences, and the MIT Center for Microbiome Informatics and Therapeutics provided support for computational resources. We thank the WHOI FT-MS facility for sample analysis and Krista Longnecker for training in metabolomics data analysis and discussions throughout the study.

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“…Nevertheless, in midAugust the MOH decided to re-vaccinate all children aged between 0 to 9 years, with the bivalent oral polio vaccine (OPV) in order to stop the spreading of wild type poliovirus. 24,25 The new polio vaccination campaign led to an animated public debate which took place in the formal media, as well as on the online platforms.…”

mentioning

confidence: 99%

Using the social structure of markets as a framework for analyzing vaccination debates: The case of emergency polio vaccination

Connelly

Ziv

Goren³

et al. 2016

Human Vaccines & Immunotherapeutics

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The Israeli public health response to wild poliovirus importation

Cited by 47 publications

References 26 publications

Public health response to the silent reintroduction of wild poliovirus to Israel, 2013–2014

Public health response to the silent reintroduction of wild poliovirus to Israel, 2013–2014

24-hour multi-omics analysis of residential sewage reflects human activity and informs public health

Using the social structure of markets as a framework for analyzing vaccination debates: The case of emergency polio vaccination

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