The Isolation of the Toxic Principles of Mamey

Morris, M. P.; Pagan, C

doi:10.1021/ja01102a514

Cited by 22 publications

(6 citation statements)

References 1 publication

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“…Mammea B/BA was first isolated from M. americana by Morris M.P. and Pagán in 1952 from a sample called mamein, which also contained two other coumarins, mammea B/BB and mammea B/BC (Morris and Pagán, 1953;Djerassi et al, 1958Djerassi et al, , 1959Djerassi et al, , 1960Crombie and Games, 1966). Mammea B/BA was also isolated from the bark of Mammea africana, by Ouahouo et al (2004), who demonstrated its anti-staphylococcal effect using the disk diffusion method, presenting an inhibition halo of 18 mm (Ouahouo et al, 2004); it should be noted that at the time of writing this article, the MIC value for this compound was not reported in the literature reviewed, so it is considered that this is the first time that the MIC 90 of 0.5-1 μg/ml has been reported and a MIC 50 value of 0.25 μg/ml, in reference and clinical MSSA and MRSA.…”

Section: Discussionmentioning

confidence: 99%

Mammea B/BA Isolated From the Seeds of Mammea americana L. (Calophyllaceae) is a Potent Inhibitor of Methicillin-Resistant Staphylococcus aureus

et al. 2022

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Staphylococcus aureus remains a pathogen of high concern in public health programs worldwide due to antibiotic resistance and emergence of highly virulent strains. Many phytochemicals have demonstrated activity against S. aureus and other Gram-positive bacteria, but the minimum inhibitory concentration (MIC) values comparable to commonly used antibiotics are needed. In the present study, bio-guided fractionation of the ethanol extract of seeds of Mammea americana L. (Calophyllaceae) throughout the antibacterial activity, against S. aureus strains that are sensitive and resistant to methicillin, led to the isolation of four coumarins identified as mammea B/BA, mammea B/BC, mammea A/AA cyclo D and mammea A/AA cyclo F, and a mixture of mammea B/BA cyclo F plus mammea B/BD cyclo F. The extract inhibited the growth of S. aureus with MIC values of 2–4 μg/ml and Mammea B/BA (MaBBA) presented MIC values in a range between 0.5 and 1.0 μg/ml in six methicillin-sensitive strains and eight methicillin-resistant strains evaluated. We consider MaBBA the most potent of all mammea coumarins reported to date, according to the literature review carried out at the time of writing of this article. Toxicity assessment in vivo against the nematode Caenorhabditis elegans and in vitro against human fibroblasts of the extract and the compound MaBBA indicated that both had low toxicity.

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Section: Discussionmentioning

confidence: 99%

Mammea B/BA Isolated From the Seeds of Mammea americana L. (Calophyllaceae) is a Potent Inhibitor of Methicillin-Resistant Staphylococcus aureus

et al. 2022

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“…Morris and Pagán. were the first to report some properties of mamey, including antimicrobial and toxic properties of fruit seeds of this tree [ 25 ]; other parts of mamey, such as leaves, stems, and fruit, have also shown medicinal properties. Frame et al evaluated the antituberculous effect against Mycobacterium smegmatis from 50 extracts of plants belonging to tropical flora in Puerto Rico.…”

Section: Discussionmentioning

confidence: 99%

Susceptibility ofPorphyromonas gingivalisandStreptococcus mutansto Antibacterial Effect fromMammea americana

Herrera

Ospina

Mercado

et al. 2014

Advances in Pharmacological Sciences

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The development of periodontal disease and dental caries is influenced by several factors, such as microorganisms of bacterial biofilm or commensal bacteria in the mouth. These microorganisms trigger inflammatory and immune responses in the host. Currently, medicinal plants are treatment options for these oral diseases. Mammea americana extracts have reported antimicrobial effects against several microorganisms. Nevertheless, this effect is unknown against oral bacteria. Therefore, the aim of this study was to evaluate the antibacterial effect of M. americana extract against Porphyromonas gingivalis and Streptococcus mutans. For this, an experimental study was conducted. Ethanolic extract was obtained from seeds of M. americana (one oil phase and one ethanolic phase). The strains of Porphyromonas gingivalis ATCC 33277 and Streptococcus mutans ATCC 25175 were exposed to this extract to evaluate its antibacterial effect. Antibacterial activity was observed with the two phases of M. americana extract on P. gingivalis and S. mutans with lower MICs (minimum inhibitory concentration). Also, bactericidal and bacteriostatic activity was detected against S. mutans, depending on the concentration of the extract, while on M. americana extract presented only bacteriostatic activity against P. gingivalis. These findings provide important and promising information allowing for further exploration in the future.

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“…Schneid 0.5–8 μg/mL against Gram-positive bacteria, 2 μg/mL E . coli, < 1 μg/mL against M. smegmatis [ 69 , 70 ] 4 Mammea B/BA Mammea americana L. 0.5–1 μg/mL against methicillin-sensitive and methicillin-resistant S. aureus strains [ 74 , 77 ] 5 Cannabinoids (e.g., cannabidiol, cannabigerol) Cannabis sativa L. 1–4 μg/mL against MRSA , multi-drug resistant Streptococcus pneumoniae, Enterococcus faecalis , and Clostridioides difficile [ 85 , 86 ] 6 27- epi -Scutianine N Scutia buxifolia Reissek 1.56 μg/mL against Enterobater aerogenes [ 126 ] 7 Berberine Hydrastis canadensis. L , Coptis chinensis Franch.…”

Section: Plants As Potential Source Of New Antibacterial Agentsmentioning

confidence: 99%

Plant antibacterials: The challenges and opportunities

Berida,

Adekunle,

Dada-Adegbola

et al. 2024

Heliyon

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The Isolation of the Toxic Principles of Mamey

Cited by 22 publications

References 1 publication

Mammea B/BA Isolated From the Seeds of Mammea americana L. (Calophyllaceae) is a Potent Inhibitor of Methicillin-Resistant Staphylococcus aureus

Mammea B/BA Isolated From the Seeds of Mammea americana L. (Calophyllaceae) is a Potent Inhibitor of Methicillin-Resistant Staphylococcus aureus

Susceptibility ofPorphyromonas gingivalisandStreptococcus mutansto Antibacterial Effect fromMammea americana

Plant antibacterials: The challenges and opportunities

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