The isolation of cytotoxic necrotizing factor (CNF)-producing Escherichia coli from the intestinal contents of babies who died of Sudden Infant Death Syndrome (SIDS) and other causes as well as from the faeces of healthy babies

Bettelheim, K. A.; Evangelidis, H.; Pearce, J.L.; Goldwater, Paul N.; Luke, R. K. J.

doi:10.1016/0147-9571(93)90065-d

Cited by 12 publications

(7 citation statements)

References 10 publications

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“…Blood and lung tissue taken aseptically during the post‐mortem examination were studied microbiologically. Intestinal cultures were also taken as reported in previous studies [13–15]. The determination of the cause of death was performed independently following a standard protocol.…”

Section: Methodsmentioning

confidence: 99%

“…As is common in SIDS research, the choice of appropriate controls posed a problem. In a number of our earlier investigations in which faecal specimens were examined, healthy babies of similar age and sex were used [13–15]; however, in a study such as this which is dependent on the use of post‐mortem specimens, we were totally reliant on similar specimens from other dead infants. Infants who died from causes other than SIDS during the period of study in Victoria were included as a control group.…”

Section: Methodsmentioning

confidence: 99%

“…The studies of Bettelheim et al [13–15] showed a possible association between SIDS and the presence of toxigenic E. coli in the intestine. These have been confirmed by studies from Tasmania [16].…”

Section: Introductionmentioning

confidence: 99%

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ExtraintestinalEscherichia coliisolations from SIDS cases and other cases of sudden death in Victoria, Australia

Pearce

Luke

Bettelheim

1999

FEMS Immunology &Amp; Medical Microbiology

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This investigation is an extension of previous studies on the possible role of intestinal Escherichia coli in sudden infant death syndrome (SIDS) to include the isolation of extraintestinal E. coli. The lungs of 52 and the blood of 144 SIDS infants were cultured and isolates were investigated. E. coli was isolated from about a quarter of post-mortem lung samples and about 15% of blood samples from SIDS infants. The isolates were subjected to microbiological studies, including serotyping and haemolysin assays. The majority were found to belong to serogroups commonly associated with bacteraemia. These results may indicate that extraintestinal E. coli plays a role in SIDS.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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ExtraintestinalEscherichia coliisolations from SIDS cases and other cases of sudden death in Victoria, Australia

Pearce

Luke

Bettelheim

1999

FEMS Immunology &Amp; Medical Microbiology

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“…So hat z. B. die Arbeitsgruppe von Bettelheim et al [2] ausgiebige Untersuchungen in dieser Richtung angestellt, jedoch gezeigt, dass entweder keine Unterschiede zwischen SIDS-und Nicht-SIDS-Kindern vorhanden waren, oder es war bei keinem der untersuchten Fälle das typische Bild einer schweren Kolitis nachweisbar.…”

Section: Diskussionunclassified

Akute, fatal verlaufende, nekrotisierende Kolitis bei einem Säugling

Koch¹,

Reich²,

Woziwodzki³

et al. 2000

Monatsschrift Kinderheilkunde

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“…One of these reasons is challenge by an infecting agent or antigen such as a toxin [8]. Recent literature has identified several species of toxigenic bacteria or their toxins in SIDS infants [9–41]. Our group has concentrated on enteric organisms and their toxins and it is antibodies to these toxins that are studied in this report.…”

Section: Introductionmentioning

confidence: 99%

Immunological evidence for a bacterial toxin aetiology in sudden infant death syndrome

Siarakas

Brown

Murrell

1999

FEMS Immunology &Amp; Medical Microbiology

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Toxin-specific antibodies to clostridial, enterobacterial and staphylococcal toxins implicated in sudden infant death syndrome were studied in sera from sudden infant death syndrome infants and a comparison group of infants (babies with phenylketonuria). The results indicated a higher proportion of sera from sudden infant death syndrome infants contained IgA that bound to clostridial and enterobacterial toxins but a higher proportion of sera from the phenylketonuria comparison group contained IgA that bound staphylococcal toxins. The higher proportion of serum samples with IgG and IgM in the healthy comparison babies serum probably indicated immunity in this group of babies to these toxins. The effect of gender and age had a minimal effect on the incidence of these antibodies. The presence of toxin-specific antibodies in sudden infant death syndrome and the of comparison infants suggests that all infants are exposed to these toxins and most babies successfully overcome the toxic challenge. Some infants with predisposing risk factors (temperature change, smoking, infection, immune development, sleeping position, etc.) that could affect the baby's immune competency could succumb to these and possibly other toxins. This immunological evidence further strengthens the view that bacterial toxins are a significant cause of sudden infant death syndrome.

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The isolation of cytotoxic necrotizing factor (CNF)-producing Escherichia coli from the intestinal contents of babies who died of Sudden Infant Death Syndrome (SIDS) and other causes as well as from the faeces of healthy babies

Cited by 12 publications

References 10 publications

ExtraintestinalEscherichia coliisolations from SIDS cases and other cases of sudden death in Victoria, Australia

ExtraintestinalEscherichia coliisolations from SIDS cases and other cases of sudden death in Victoria, Australia

Akute, fatal verlaufende, nekrotisierende Kolitis bei einem Säugling

Immunological evidence for a bacterial toxin aetiology in sudden infant death syndrome

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