The isolation of Aspergillus fumigatus from respiratory tract specimens in heart transplant recipients is highly predictive of invasive aspergillosis1

Muñóz, Patricia; Alcalá, Luís; Condé, M.; Palomo, Jesús; Yáñez, Javier; Peláez, Teresa; Bouza, Emilio

doi:10.1097/01.tp.0000044358.99414.b8

Cited by 72 publications

(44 citation statements)

References 19 publications

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“…In immunosupressed patients e.g. post-transplantation, isolation of A. fumigatus from a respiratory specimen is considered to have a high positive predictive value of invasive aspergillosis [5]. In immune-competent patients with CNPA, however, reliable diagnostic criteria are not available and histopathological confirmation cannot always be obtained [6,8].…”

Section: Nontuberculous Mycobacterial Disease H Kunst Et Almentioning

confidence: 99%

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Nontuberculous mycobacterial disease and Aspergillus-related lung disease in bronchiectasis

Kunst

Wickremasinghe²,

Wells³

et al. 2006

European Respiratory Journal

123

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The aim of the present study was to determine whether patients with bronchiectasis and nontuberculous mycobacteria (NTM) have a higher prevalence of Aspergillus-related lung disease.A series of 30 consecutive patients with bronchiectasis and NTM (cases) were compared with 61 patients with bronchiectasis and no evidence of NTM (controls). Aspergillus serology and computerised tomography of the thorax were used to identify Aspergillus-related lung diseases, including aspergilloma, allergic bronchopulmonary aspergillosis and chronic necrotising pulmonary aspergillosis.The rate of positive Aspergillus serology was higher in cases with NTM disease compared with controls (10 out of 30 versus six out of 61). The radiological features of Aspergillus-related lung disease were also more common among patients with NTM disease than controls (six out of 30 versus none out of 61). This association between NTM disease and Aspergillus-related lung disease remained significant after adjustment for confounding effects of age and lung function (adjusted odds ratio 5.1, 95% confidence interval 1.5-17.0).Patients with bronchiectasis and nontuberculous mycobacterial disease have a higher prevalence of coexisting Aspergillus-related lung disease than patients with bronchiectasis and without nontuberculous mycobacteria. Identification of Aspergillus-related lung disease is important as prognosis amongst undetected cases is invariably poor.

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Section: Nontuberculous Mycobacterial Disease H Kunst Et Almentioning

confidence: 99%

“…In addition, sputum examination for Aspergillus fumigatus is often unreliable [5,6]. Pulmonary disease caused by A. fumigatus is traditionally classified into three distinct groups, namely aspergilloma, ABPA and invasive aspergillosis.…”

mentioning

confidence: 99%

Nontuberculous mycobacterial disease and Aspergillus-related lung disease in bronchiectasis

Kunst

Wickremasinghe²,

Wells³

et al. 2006

European Respiratory Journal

123

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“…Recovery of Aspergillus species from respiratory tract cultures, particularly of A. fumigatus, is highly predictive of invasive aspergillosis in these patients (212). Reoperation, CMV disease, posttransplant hemodialysis, and the existence of an episode of invasive aspergillosis in the institution's heart transplant program 2 months before or after the transplantation date have been shown to be independent risk factors for invasive aspergillosis in heart transplant recipients (213).…”

Section: Heart Transplant Recipientsmentioning

confidence: 99%

“…Aspergillus can be detected in ϳ10% of heart transplant recipients after transplantation (212). Recovery of Aspergillus species from respiratory tract cultures, particularly of A. fumigatus, is highly predictive of invasive aspergillosis in these patients (212).…”

Section: Heart Transplant Recipientsmentioning

confidence: 99%

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AspergillusInfections in Transplant Recipients

2005

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Aspergillus infections are occurring with an increasing frequency in transplant recipients. Notable changes in the epidemiologic characteristics of this infection have occurred; these include a change in risk factors and later onset of infection. Management of invasive aspergillosis continues to be challenging, and the mortality rate, despite the use of newer antifungal agents, remains unacceptably high. Performing molecular studies to discern new targets for antifungal activity, identifying signaling pathways that may be amenable to immunologic interventions, assessing combination regimens of antifungal agents or combining antifungal agents with modulation of the host defense mechanisms, and devising diagnostic assays that can rapidly and reliably diagnose infections represent areas for future investigations that may lead to further improvement in outcomes

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Aspergillosis

Richardson

2010

Topley &Amp; Wilson's Microbiology and Microbial Infections

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The isolation of Aspergillus fumigatus from respiratory tract specimens in heart transplant recipients is highly predictive of invasive aspergillosis1

Abstract: The isolation of from the respiratory tract of a heart transplant recipient is highly predictive of invasive aspergillosis.

Cited by 72 publications

References 19 publications

Nontuberculous mycobacterial disease and Aspergillus-related lung disease in bronchiectasis

Nontuberculous mycobacterial disease and Aspergillus-related lung disease in bronchiectasis

AspergillusInfections in Transplant Recipients

Aspergillosis

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