The Isolation of a New<i>S</i>-Methyl Benzothioate Compound from a Marine-Derived<i>Streptomyces</i>sp.

Mahyudin, Nor Ainy; Blunt, John W.; Cole, A. L. J.; Munro, Murray H. G.

doi:10.1155/2012/894708

Cited by 13 publications

(14 citation statements)

References 12 publications

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“…Streptomyces are widely distributed in global marine ecosystems, such as marine sediments and seawater, marine animals and algae (Blunt et al 2013). Streptomyces have been isolated from six kinds of ascidians (Aplidium lenticulum, Didemnum sp., E. turbinata, Molgula manhattensis, Styela canopus and Styela clava) (Chen et al 2018b), and some compounds have been isolated from ascidian-derived Streptomyces, such as polyketides (bisanthraquinones 1-2, griseorhodin A, germicidin), alkaloids (piericidin C7, C8, A1, A2, bohemamine, etc) and other compounds (Li and Piel 2002;Socha et al 2006;Hayakawa et al 2007;Mahyudin et al 2012;Pei et al 2017;Chen et al 2018b). Among the 135 strains with antimicrobial activity, 39 strains (28Á89%) belonged to the genus Streptomyces in this study.…”

Section: Discussionmentioning

confidence: 99%

Phylogenetic analysis and screening of antimicrobial and cytotoxic activities of culturable bacteria associated with the ascidian Botryllus schlosseri

Chen

Liu

et al. 2020

J. Appl. Microbiol.

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Aims Isolating culturable bacteria associated with ascidian (Botryllus schlosseri) and investigating their bioactivities to discover new marine microbial resources with potential to produce novel bioactive natural products. Methods and Results A total of 357 bacteria were isolated from the ascidian B. schlosseri from the coast of Weihai in the north Yellow Sea, China. Of these, 203 isolates were identified by 16S rRNA gene sequencing and they belonged to 52 genera from 30 families in five phyla. The antimicrobial activities and cytotoxic activities of all isolates were determined. Of the 357 isolates, 135 isolates demonstrated antimicrobial activities, and the crude extracts of five isolates showed strong cytotoxicity against human hepatocellular carcinoma Bel 7402 or human cervical carcinoma HeLa cells. Conclusions Our study revealed the diversity of bacteria associated with the ascidian B. schlosseri and reported a broad spectrum of antimicrobial and cytotoxic activities displayed by these isolates. Significance and Impact of the Study Our results suggest that the culturable bacteria associated with the ascidian B. schlosseri may be a potential source for novel bioactive compounds.

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Section: Discussionmentioning

confidence: 99%

Phylogenetic analysis and screening of antimicrobial and cytotoxic activities of culturable bacteria associated with the ascidian Botryllus schlosseri

Chen

Liu

et al. 2020

J. Appl. Microbiol.

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“…This phenazine has antimicrobial activity against Vibrio anguillarum and Vibrio parahaemolyticus , lethal activity against Artemia salina , and enzyme inhibiting activity against Alpha-glucosidase [ 53 ]. Bohemamine ( 85 ) was isolated from Streptomyces sp., a bacterial associated with an unidentified ascidian collected from Lyttelton Harbor, New Zealand [ 115 ]. Four known diketopiperazine alkaloids, cyclo (6-OH- d -Pro- l -Phe) ( 86 ), bacillusamide B ( 87 ), cyclo ( l -Pro- l -Leu) ( 88 ) and cyclo ( l -Pro- l -Ile) ( 89 ), were isolated from actinobacteria Streptomyces sp.…”

Section: Structure and Bioactivities Of Natural Productsmentioning

confidence: 99%

Biological and Chemical Diversity of Ascidian-Associated Microorganisms

Chen

et al. 2018

Marine Drugs

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Ascidians are a class of sessile filter-feeding invertebrates, that provide unique and fertile niches harboring various microorganisms, such as bacteria, actinobacteria, cyanobacteria and fungi. Over 1000 natural products, including alkaloids, cyclic peptides, and polyketides, have been isolated from them, which display diverse properties, such as antibacterial, antifungal, antitumor, and anti-inflammatory activities. Strikingly, direct evidence has confirmed that ~8% of natural products from ascidians are actually produced by symbiotic microorganisms. In this review, we present 150 natural products from microorganisms associated with ascidians that have been reported up to 2017.

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“…without biological evaluation. 12 Hexasubstituted benzothioates are rarely found from sources other than actinobacteria, with the only examples being mortivinactin B from the fungus Mortierella vinacea 13 and polycarpamine B from the marine ascidian Polycarpa auzata. 14 Using a cell-based assay to evaluate antidiabetic compounds, we observed that suncheonosides A−D (1−4, respectively) increased the production of adiponectin during adipogenesis in human bone marrow mesenchymal stem cells (hBM-MSCs).…”

Section: Journal Of Natural Productsmentioning

confidence: 99%

Suncheonosides A–D, Benzothioate Glycosides from a Marine-Derived Streptomyces sp.

et al. 2015

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A marine-derived Streptomyces strain, SSC21, was isolated from the sediment of Suncheon Bay, Republic of Korea. Chemical analysis of the bacterial strain resulted in the isolation of four new metabolites, suncheonosides A-D (1-4, respectively), each bearing a sulfur atom. The planar structures of the suncheonosides were identified as hexasubstituted benzothioate glycosides by combined spectroscopic analyses. Analysis of the configuration of the sugar moieties based on ROESY nuclear magnetic resonance correlations, one-bond (1)H-(13)C coupling constant analysis, and chemical derivatizations indicated that the suncheonosides incorporate only l-rhamnose. Suncheonosides A, B, and D promoted adiponectin production in a concentration-dependent manner during adipogenesis in human mesenchymal stem cells, suggesting antidiabetic potential.

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The Isolation of a NewS-Methyl Benzothioate Compound from a Marine-DerivedStreptomycessp.

Cited by 13 publications

References 12 publications

Phylogenetic analysis and screening of antimicrobial and cytotoxic activities of culturable bacteria associated with the ascidian Botryllus schlosseri

Phylogenetic analysis and screening of antimicrobial and cytotoxic activities of culturable bacteria associated with the ascidian Botryllus schlosseri

Biological and Chemical Diversity of Ascidian-Associated Microorganisms

Suncheonosides A–D, Benzothioate Glycosides from a Marine-Derived Streptomyces sp.

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