The Isolation and General Properties of Terramycin and Terramycin Salts

Regna, Peter P.; Solomons, I. A.; Murai, Kotaro; Timreck, Albert E.; Brunings, K. J.; Lazier, Wilbur A.

doi:10.1021/ja01153a050

Cited by 63 publications

(17 citation statements)

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“…The various tetracyclines have been the subject of thorough investigations regarding their chemical and physical as well as pharmacological properties (Regna et al 1951, Stephens et al 1952, Boothe et al 1953, Cunningham et al 1953, Conover et al 1953, Dowling 1955, Regna 1955, Lepper 1956, Musselman 1956, Kunin et al 1959, Kunin and Finland 1961, Spitzy 1962.…”

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confidence: 99%

“…Hydrochloride compound is partly soluble in water but then forms an acid solution which limits its use (Regna et al 1951, Stephens et al 1952, Conover et al 1953, Regna 1955, Spitzy 1962. Hydrochloride compound is partly soluble in water but then forms an acid solution which limits its use (Regna et al 1951, Stephens et al 1952, Conover et al 1953, Regna 1955, Spitzy 1962.…”

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confidence: 99%

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Daily Growth in Length of Diaphysis Measured by Oxytetracycline in Rabbit Normally

Hansson

1967

Acta Orthopaedica Scandinavica

111

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confidence: 99%

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confidence: 99%

Daily Growth in Length of Diaphysis Measured by Oxytetracycline in Rabbit Normally

Hansson

1967

Acta Orthopaedica Scandinavica

111

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“…[4][5][6][7] Both anionic sites are stabilized by resonance, and they are separated from each other by carbon 12a. This sp 3 hybrid atom isolates the two lightabsorbing regions and makes it possible to determine their pK a values independently by spectrophotometry.…”

Section: Resultsmentioning

confidence: 99%

Spectrophotometric determination of acidity constants of 4‐dedimethylamino sancycline (Col‐3), a new antitumor drug

Pinsuwan

Alvarez‐Núñez

Tabibi

et al. 1999

Journal of Pharmaceutical Sciences

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A spectrophotometric technique was used to determine the acidity constants of 4-dedimethylamino sancycline (Col-3), a new antitumor drug. The apparent pKa values of Col-3 in 0.5% methanol aqueous media at approximately 25 degrees C with a constant ionic strength of 0.2 were calculated manually and graphically to be 5.64 +/- 0.17 (pKa1) and 8.35 +/- 0.07 (pKa2). In addition, the computer program SQUAD was used to confirm Col-3 pKa values. The pKa values obtained by SQUAD were pKa1 5.63 +/- 0.14 and pKa2 8.39 +/- 0.04. These results are in agreement with the tetracycline-like structure of Col-3.

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“…The marked tendency of OTC to form complexes with certain inorganic salts was noted by REGNA et al (1951). ALBERT (1953) and ALBERT and REES (1956) studied in some detail the affinity of CTC, OTC and TC for metallic ions.…”

Section: Chelation Of Metal Ionsmentioning

confidence: 94%

Antibiotics

1967

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AII rights, especially that of tnmslation into foreign languages, reserved. It is also forbidden to reproduce this book, either whole DedicationFor most areas of scientific pursuit, there is usually that rare investigator who has the imagination to conceive ideas, who has faith in his visions, and who has the ability to critically test his concepts in the laboratory. Almost invariably, this scientist also inspires younger men to enthusiastically enter into his research program. To him should go the accolades and the recognitions of the esteem in which he is held. As only a small part of this esteem, we wish to dedicate these books to Professor SELMAN A. W AKSMAN in appreciation of his leadership and contributions in all facets of antibiotic research. PrefaceThe idea for publishing these books on the mechanism of action and on the biosynthesis of antibiotics was born of frustration in our attempts to keep abreast of the literature. Gone were the years when we were able to keep a bibliography on antibiotics and feel confident that we could find everything that was being published on this subject. These fields of investigation were moving forward so rapidly and were encompassing so wide a range of specialized areas in microbiology and chemistry that it was almost impossible to keep abreast of developments. In our naivete and enthusiasm, however, we were unaware that we were toying with an idea that might enmesh us, that we were creating an entity with a life of its own, that we were letting loose a Golom who instead of being our servant would be our master.That we set up ideals for these books is obvious; they would be current guides to developments and information in the areas of mechanism of action and biosynthesis of antibiotics. For almost every subject, we wished to enlist the aid of an investigator who himself had played a part in determining the nature of the phenomena that were being discussed. One concept for the books was that they include only antibiotics for which a definitive, well-documented mechanism of action or biosynthetic pathway was known. Yet, such an approach would not entirely serve the purpose we projected, for it would not encompass all of the information available in these fields of antibiotic investigations and blind searches for the original literature would still have to be made. We therefore chose to include any and all antibiotics about which some pertinent information had been published. It was obvious even at the start that such a compilation, integration, and analysis of information could never be complete unless scientific investigations ceased at the moment the last manuscript was submitted-an end that was neither desirable nor possible. An addendum was therefore included at the end of the volume and left open for the addition of new information until the last pages of the regular articles had been printed.The original concept has also been further expanded as the authors of several papers found it advisable to elaborate on their subject. Some of the articles included discussions...

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The Isolation and General Properties of Terramycin and Terramycin Salts

Cited by 63 publications

References 0 publications

Daily Growth in Length of Diaphysis Measured by Oxytetracycline in Rabbit Normally

Daily Growth in Length of Diaphysis Measured by Oxytetracycline in Rabbit Normally

Spectrophotometric determination of acidity constants of 4‐dedimethylamino sancycline (Col‐3), a new antitumor drug

Antibiotics

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