The Irritable Bowel Syndrome: A Paroxysmal Motor Disorder

Gastrointestinal Motility Disorders in Patients with Inactive Crohn's Disease

“…The clustered contraction pattern probably corresponds to the repetitive bursts of action potentials observed in ligated loops of rabbit ileum exposed to invasive strains of bacteria (9,(32)(33)(34) or substances producing mucosal damage (35). This pattern is rarely observed in normal subjects (13) but is more frequent in the irritable bowel syndrome (36)(37)(38), after meals in patients with mechanical obstruction (25), in patients with radiation enteropathy (39), and also in healthy adults aged more than 55-60 years (21). It was observed in 24 of our 35 Crohn's disease patients, with an incidence up to hundred times higher than in healthy controls.…”

Guidelines on the irritable bowel syndrome: mechanisms and practical management

“…This may account for some inconsistencies in published reports, as many studies have been small and of short duration. Small bowel motor disturbances reported include: increased frequency and duration of discrete cluster contractions,138 – 141 increased frequency of the migrating motor complex (MMC),140 – 142 more retrograde duodenal and jejunal contractions,140 143 and an exaggerated motor response to meal ingestion,140 142 ileal distension, and cholecystokinin (CCK) 142. Corticotrophin releasing hormone (CRH) has been reported to increase the number of discrete cluster contractions 144.…”

Lactose Intolerance

“…Visceral sensitivity [98], as well as bowel motor abnormalities [99,100] have been documented in irritable bowel syndrome. Compared with healthy people, patients with irritable bowel syndrome or functional dyspepsia, i.e.…”