The irradiation facility at the AGOR cyclotron

Brandenburg, S.; Ostendorf, Reint; Hofstee, M.A.; Kiewiet, Harry; Beijers, H.

doi:10.1016/j.nimb.2007.04.304

Cited by 10 publications

(8 citation statements)

References 11 publications

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“…The superconducting AGOR cyclotron accelerates protons up to 190 MeV with a frequency range of 24-62 MHz [25]. Details about the setup of the proton beam line can be found in [26].…”

Section: Methodsmentioning

confidence: 99%

Dose and dose rate measurements in proton beams using the luminescence of beryllium oxide

Teichmann¹,

Torres²,

Goethem³

et al. 2018

J. Inst.

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“…The superconducting AGOR cyclotron accelerates protons up to 190 MeV with a frequency range of 24-62 MHz [25]. Details about the setup of the proton beam line can be found in [26].…”

Section: Methodsmentioning

confidence: 99%

Dose and dose rate measurements in proton beams using the luminescence of beryllium oxide

Teichmann¹,

Torres²,

Goethem³

et al. 2018

J. Inst.

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“…The experiments use mainly proton and carbon beams and have two main focal points: in vivo studies of non-local effects in (partial) irradiations of organs such as parotid [86], heart-lung system [87,88], and neural tissues [89] and in vitro studies of various aspects of the radiation response of stem cells [90,91]. For this research, a versatile, modular beamline [92] has been built that is also used for experiments in medical radiation physics and for radiation hardness testing with both protons and various heavy ions. The on-site laboratory facilities for the radiation biology research comprise an animal accommodation for wild-type rodents and two laboratories equipped with CO 2 incubators and flow cabinets.…”

Section: Kvi-cartmentioning

confidence: 99%

“…For this research, a versatile, modular beamline [ 92 ] has been built that is also used for experiments in medical radiation physics and for radiation hardness testing with both protons and various heavy ions. The on-site laboratory facilities for the radiation biology research comprise an animal accommodation for wild-type rodents and two laboratories equipped with CO 2 incubators and flow cabinets.…”

Section: Kvi-cartmentioning

confidence: 99%

Biomedical Research Programs at Present and Future High-Energy Particle Accelerators

et al. 2020

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Biomedical applications at high-energy particle accelerators have always been an important section of the applied nuclear physics research. Several new facilities are now under constructions or undergoing major upgrades. While the main goal of these facilities is often basic research in nuclear physics, they acknowledge the importance of including biomedical research programs and of interacting with other medical accelerator facilities providing patient treatments. To harmonize the programs, avoid duplications, and foster collaboration and synergism, the International Biophysics Collaboration is providing a platform to several accelerator centers with interest in biomedical research. In this paper, we summarize the programs of various facilities in the running, upgrade, or construction phase.

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“…In our experiment, we use a fixed energy of 150 MeV. A detailed description of this accelerator is given in [61]. It has many similarities to the clinical proton cyclotron and is therefore indicated to test all properties of the block detectors with phantom experiments:…”

Section: Acceleratorsmentioning

confidence: 99%

Comparison of LSO and BGO block detectors for prompt gamma imaging in ion beam therapy

Hueso-González¹,

Biegun²,

Dendooven³

et al. 2015

J. Inst.

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A major weakness of ion beam therapy is the lack of tools for verifying the particle range in clinical routine. The application of the Compton camera concept for the imaging of prompt gamma rays, a by-product of the irradiation correlated to the dose distribution, is a promising approach for range assessment and even three-dimensional in vivo dosimetry.Multiple position sensitive gamma ray detectors arranged in scatter and absorber planes, together with an imaging algorithm, are required to reconstruct the prompt gamma emission density map. Conventional block detectors deployed in Positron Emission Tomography (PET), which are based on Lu 2 SiO 5 :Ce (LSO) and Bi 4 Ge 3 O 12 (BGO) scintillators, are suitable candidates for the absorber of a Compton camera due to their high density and absorption efficiency with respect to the prompt gamma energy range (several MeV).We compare experimentally LSO and BGO block detectors in clinical-like radiation fields in terms of energy, spatial and time resolution. The high energy range compensates for the low light yield of the BGO material and boosts significantly its performance compared to the PET scenario. Notwithstanding the overall superiority of LSO, BGO catches up in the field of prompt gamma imaging and can be considered as a competitive alternative to LSO for the absorber plane due to its lower price and the lack of intrinsic radioactivity.

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The irradiation facility at the AGOR cyclotron

Cited by 10 publications

References 11 publications

Dose and dose rate measurements in proton beams using the luminescence of beryllium oxide

Dose and dose rate measurements in proton beams using the luminescence of beryllium oxide

Biomedical Research Programs at Present and Future High-Energy Particle Accelerators

Comparison of LSO and BGO block detectors for prompt gamma imaging in ion beam therapy

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