The Iron Metabolism of Hemochromatosis

Destruction of the Red Blood Corpuscles in Health and Disease

“…Furthermore, local injurv without blood extravasation may result, under appropriate conditions, "in a local accumulation of hemosiderin (179). And in hemochromatosis, a disease characterized by the extensive deposition of iron-containing pigments, there is no evidence whatever of increased blood-destruction but much that, is practically conclusive against it (131), (205), (92). The peculiar abundance of hemosiderin in the hepatic pa.renchyma of patients with pernicious anemia can scarcely attest, as so many think, to a portIaI disintegration of erythrocytes.…”