The Iron Chelator, DIBI, Reduces Bacterial Load and Inflammation in Experimental Lung Infection
Xiyang Zhang,
Rhea Nickerson,
Lauren Burton
et al.
Abstract:Iron plays a critical role in lung infections due to its function in the inflammatory immune response but also as an important factor for bacterial growth. Iron chelation represents a potential therapeutic approach to inhibit bacterial growth and pathologically increased pro-inflammatory mediator production. The present study was designed to investigate the impact of the iron chelator, DIBI, in murine lung infection induced by intratracheal Pseudomonas aeruginosa (strain PA14) administration. DIBI (80mg/kg) wa… Show more
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