The iPSYCH2012 case–cohort sample: new directions for unravelling genetic and environmental architectures of severe mental disorders

Pedersen, Carsten Bøcker; Bybjerg‐Grauholm, Jonas; Pedersen, Marianne Giørtz; Grove, Jakob; Agerbo, Esben; Bækvad-Hansen, Marie; Poulsen, Jesper Buchhave; Hansen, Christine Søholm; McGrath, John J.; Als, Thomas Damm; Goldstein, Jackie; Neale, B. M.; Daly, Mark J.; Hougaard, David M.; Mors, Ole; Nordentoft, Merete; Børglum, Anders D.; Werge, Thomas; Mortensen, Preben Bo

doi:10.1038/mp.2017.196

Cited by 280 publications

(325 citation statements)

References 87 publications

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“…Given the high prevalence of premorbid intelligence deficits or ID in the (neuro)psychiatric population (Stratta et al 2008;Verhoeven & Egger 2014;Pedersen et al 2018), development of specific tasks is needed to disentangle g and specific domaindependent cognitive processes in this group.…”

Section: Discussionmentioning

confidence: 99%

“…Several key risk factors of neuropsychiatric disorders (e.g. schizophrenia, bipolar disorder, affective disorder, autism or attention deficit hyperactivity disorder) are being documented, such as paternal age, psychiatric family history, neonatal vitamin D deficiency or socioeconomic adversity (Pedersen et al 2018). Level of intelligence also seems to be a causal factor in psychiatric illness, showing people with ID of all ages to show substantially more health problems (e.g.…”

Section: Introductionmentioning

confidence: 99%

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Inhibition, shifting and updating in relation to psychometric intelligence across ability groups in the psychiatric population

Biesmans

Aken

Frunt³

et al. 2018

J intellect Disabil Res

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Background Assessment of intelligence and executive function (EF) is common in complex neuropsychiatric practice. Although previous studies have shown that EF and intelligence are related, it is unknown whether these constructs relate to one another in a similar manner across different ability groups (mild intellectual disability, borderline intellectual disability and normal/high intelligence). This study therefore examines the relation between three EFs (inhibition, shifting and updating) and intelligence in a heterogeneous psychiatric sample. It is hypothesised that the strength of the relation between intelligence and the three EFs decreases when the level of intelligence increases, in accordance with Spearman's Law of Diminishing Returns. Methods In a cross‐sectional, between and within subject design, one of the three intelligence tests (Kaufman Adolescent and Adult Intelligence Test and Wechsler Adult Intelligence Scale – third and fourth editions) and several EF tests (Stroop Colour–Word Test, Trail Making Test and Spatial Working Memory task) were administered to 250 neuropsychiatric inpatients and outpatients (Mage = 39.8, standard deviation = 14.3, 52.8% male). Based upon their full‐scale IQ score, patients were divided into three ability groups (mild intellectual disability, borderline intellectual disability or normal/high intelligence). The relation between EF and intelligence was assessed through analyses of the correlation pattern; groups were compared using analysis of covariance. Results Analyses showed significant correlations between the constructs of EF and intelligence. A significant interaction effect was found for shifting, with highest correlations in the normal to high intelligence group, but not for inhibition and updating. Conclusions Results support a specific role for shifting in this EF–intelligence relation. The correlational pattern of updating and intelligence, as well as the differential relation of shifting and intelligence across ability groups, suggests that EF tasks may not measure distinct EFs in lower intellectual ability but rely on cognitive primitives such as processing speed. EF tasks can be considered less valid indicators of EF ability. Implications in terms of the need for development of specific tasks to measure cognition in low intellectual ability are discussed.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Inhibition, shifting and updating in relation to psychometric intelligence across ability groups in the psychiatric population

Biesmans

Aken

Frunt³

et al. 2018

J intellect Disabil Res

View full text Add to dashboard Cite

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“…PKU cards for individuals who met inclusion criteria and for controls were extracted from DNSB. Additional samples [ANGI-DK(Clinic)] were obtained from the Danish Psychiatric Biobank that recruits individuals with mental disorders for genetic studies (24). The biobank holds DNA samples and demographic, familial, and clinical information, including complete records of all hospital in- and out-patient admissions and diagnoses.…”

Section: Methodsmentioning

confidence: 99%

“…ANGI-DK controls were selected from DNSB (24) based on date of birth, sex, and absence of major psychiatric disorders.…”

Section: Methodsmentioning

confidence: 99%

“…DNA was sent to the Broad Institute for genotyping on the Illumina PsychArray; 3,769 control samples were genotyped as part of ANGI-DK. Data for the remaining control samples and for 224 cases were supplied by the Lundbeck Initiative for Integrative Psychiatric Research (iPsych) consortium (24) and were genotyped at the same time and on the same platform as those for ANGI-DK. The ANGI-DK(Clinical) DNA samples were extracted from whole blood samples and sent to the Broad for genotyping on the Illumina GSA chip.…”

Section: Methodsmentioning

confidence: 99%

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The Anorexia Nervosa Genetics Initiative (ANGI): Overview and methods

Thornton

Munn‐Chernoff

Baker

et al. 2018

Contemporary Clinical Trials

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116

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Background: Genetic factors contribute to anorexia nervosa (AN); and the first genome-wide significant locus has been identified. We describe methods and procedures for the Anorexia Nervosa Genetics Initiative (ANGI), an international collaboration designed to rapidly recruit 13,000 individuals with AN as well as ancestrally matched controls. We present sample characteristics and the utility of an online eating disorder diagnostic questionnaire suitable for large-scale genetic and population research. Methods: ANGI recruited from the United States (US), Australia/New Zealand (ANZ), Sweden (SE), and Denmark (DK). Recruitment was via national registers (SE, DK); treatment centers (US, ANZ, SE, DK); and social and traditional media (US, ANZ, SE). All cases had a lifetime AN diagnosis based on DSM-IV or ICD-10 criteria (excluding amenorrhea). Recruited controls had no lifetime history of disordered eating behaviors. To assess the positive and negative predictive validity of the online eating disorder questionnaire (ED100K-v1), 109 women also completed the Structured Clinical Interview for DSM-IV (SCID), Module H. Results: Blood samples and clinical information were collected from 13,364 individuals with lifetime AN and from controls. Online diagnostic phenotyping was effective and efficient; the validity of the questionnaire was acceptable. Conclusions: Our multi-pronged recruitment approach was highly effective for rapid recruitment and can be used as a model for efforts by other groups. High online presence of individuals with AN rendered the Internet/social media a remarkably effective recruitment tool in some countries. ANGI has substantially augmented Psychiatric Genomics Consortium AN sample collection. ANGI is a registered clinical trial: clinicaltrials.gov NCT01916538; https://clinicaltrials.gov/ct2/show/NCT01916538?cond=Anorexia+Nervosa&draw=1&rank=3.

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Association of Childhood Exposure to Nitrogen Dioxide and Polygenic Risk Score for Schizophrenia With the Risk of Developing Schizophrenia

et al. 2019

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The iPSYCH2012 case–cohort sample: new directions for unravelling genetic and environmental architectures of severe mental disorders

Cited by 280 publications

References 87 publications

Inhibition, shifting and updating in relation to psychometric intelligence across ability groups in the psychiatric population

Inhibition, shifting and updating in relation to psychometric intelligence across ability groups in the psychiatric population

The Anorexia Nervosa Genetics Initiative (ANGI): Overview and methods

Association of Childhood Exposure to Nitrogen Dioxide and Polygenic Risk Score for Schizophrenia With the Risk of Developing Schizophrenia

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