Abstract:The aim of the study was to understand the effect of alterations in local ionic concentrations due to neuronal activity on calcium activity in astrocytes.Materials and Methods. In this study we investigated astrocytic calcium dynamics using confocal microscopy on hippocampal slices from Wistar rats P15-18.Results. Here we demonstrated that activation of metabotropic glutamate receptors on astrocytes led to an increase of the frequency and duration of calcium events. Elevations of the extracellular calcium conc… Show more
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