The Ion Transport Peptide Is a New Functional Clock Neuropeptide in the Fruit Fly<i>Drosophila melanogaster</i>

Hermann-Luibl, Christiane; Yoshii, Taishi; Senthilan, Pingkalai R.; Dircksen, Heinrich; Helfrich‐Förster, Charlotte

doi:10.1523/jneurosci.0111-14.2014

Cited by 96 publications

(110 citation statements)

References 44 publications

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“…ITP is involved in ion and fluid transport over the ileum, and recently has been shown to have a role in the regulation of circadian rhythm [69]. While ITP was initially isolated from CC extracts of locusts [70], it has so far not been reported to occur in CCs of dipterans.…”

Section: Diuretic Hormones -Ion Transport Peptidementioning

confidence: 99%

Peptidomics of Neuropeptidergic Tissues of the Tsetse FlyGlossina morsitans morsitans

Caers

Boonen

Abbeele³

et al. 2015

J. Am. Soc. Mass Spectrom.

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Abstract. Neuropeptides and peptide hormones are essential signaling molecules that regulate nearly all physiological processes. The recent release of the tsetse fly genome allowed the construction of a detailed in silico neuropeptide database (International Glossina Genome Consortium, Science 344, 380-386 (2014)), as well as an in-depth mass spectrometric analysis of the most important neuropeptidergic tissues of this medically and economically important insect species. Mass spectrometric confirmation of predicted peptides is a vital step in the functional characterization of neuropeptides, as in vivo peptides can be modified, cleaved, or even mispredicted. Using a nanoscale reversed phase liquid chromatography coupled to a Q Exactive Orbitrap mass spectrometer, we detected 51 putative bioactive neuropeptides encoded by 19 precursors: adipokinetic hormone (AKH) I and II, allatostatin A and B, capability/ pyrokinin (capa/PK), corazonin, calcitonin-like diuretic hormone (CT/DH), FMRFamide, hugin, leucokinin, myosuppressin, natalisin, neuropeptide-like precursor (NPLP) 1, orcokinin, pigment dispersing factor (PDF), RYamide, SIFamide, short neuropeptide F (sNPF) and tachykinin. In addition, propeptides, truncated and spacer peptides derived from seven additional precursors were found, and include the precursors of allatostatin C, crustacean cardioactive peptide, corticotropin releasing factor-like diuretic hormone (CRF/DH), ecdysis triggering hormone (ETH), ion transport peptide (ITP), neuropeptide F, and proctolin, respectively. The majority of the identified neuropeptides are present in the central nervous system, with only a limited number of peptides in the corpora cardiaca-corpora allata and midgut. Owing to the large number of identified peptides, this study can be used as a reference for comparative studies in other insects.

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Section: Diuretic Hormones -Ion Transport Peptidementioning

confidence: 99%

Peptidomics of Neuropeptidergic Tissues of the Tsetse FlyGlossina morsitans morsitans

Caers

Boonen

Abbeele³

et al. 2015

J. Am. Soc. Mass Spectrom.

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“…Similar to NPF, it peaks during the day and is CLK regulated (Fig. 1H) (Hermann-Luibl et al 2014). ITP activity also stabilizes PER in the s-LNvs at night (Hermann-Luibl et al 2014).…”

Section: Coordination Between Differentially Regulated Circadian Clocksmentioning

confidence: 82%

“…1H) (Hermann-Luibl et al 2014). ITP activity also stabilizes PER in the s-LNvs at night (Hermann-Luibl et al 2014). The short-NPF (sNPF) neuropeptide is expressed in the two LNds lacking NPF, as well as in the s-LNvs (Fig.…”

Section: Coordination Between Differentially Regulated Circadian Clocksmentioning

confidence: 91%

“…Unlike PDF, NPF and NPFR1 production is rhythmic, peaking in the mid-to late day in an apparent reverse phase with TIM and PER protein production ( Fig. 1H) (Hardin et al 1992;Park et al 2000;He et al 2013;Hermann-Luibl et al 2014). If NPF/NPFR1 is dominant over PDF signaling in a target neuron such as the s-LNvs, it would drive cAMP levels down.…”

Section: Other Neuropeptides and Evening Anticipationmentioning

confidence: 99%

“…Ion transport protein (ITP) is a neurotransmitter peptide that helps regulate evening anticipation (Hermann-Luibl et al 2014). Similar to NPF, it peaks during the day and is CLK regulated (Fig.…”

Section: Coordination Between Differentially Regulated Circadian Clocksmentioning

confidence: 99%

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Coordination between Differentially Regulated Circadian Clocks Generates Rhythmic Behavior

Top

Young

2017

Cold Spring Harb Perspect Biol

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Specialized groups of neurons in the brain are key mediators of circadian rhythms, receiving daily environmental cues and communicating those signals to other tissues in the organism for entrainment and to organize circadian physiology. In Drosophila, the "circadian clock" is housed in seven neuronal clusters, which are defined by their expression of the main circadian proteins, Period, Timeless, Clock, and Cycle. These clusters are distributed across the fly brain and are thereby subject to the respective environments associated with their anatomical locations. While these core components are universally expressed in all neurons of the circadian network, additional regulatory proteins that act on these components are differentially expressed, giving rise to "local clocks" within the network that nonetheless converge to regulate coherent behavioral rhythms. In this review, we describe the communication between the neurons of the circadian network and the molecular differences within neurons of this network. We focus on differences in protein-expression patterns and discuss how such variation can impart functional differences in each local clock. Finally, we summarize our current understanding of how communication within the circadian network intersects with intracellular biochemical mechanisms to ultimately specify behavioral rhythms. We propose that additional efforts are required to identify regulatory mechanisms within each neuronal cluster to understand the molecular basis of circadian behavior. C ircadian rhythms are behavioral and physiological responses that allow anticipation of daily changes in the environment, such as day/ night cycles. Indeed, circadian rhythms are entrained by diurnal oscillations in light, temperature, and food availability, each of which can be considered a "zeitgeber," or "time giver." Such anticipatory behavior of daily events confers adaptive advantages on individuals that organize physiology around planetary rhythms, as well as within a species as a whole, for purposes of mating, cooperation, protection, etc. In a sense, rhythmic anticipation can be thought of as a primitive mechanism of planning and cognition.The circadian clock, consisting of transcriptional negative feedback loops, underlies the regulation of a ∼24-h behavioral rhythm. The molecular architecture of this feedback loop is conserved across the majority of multicellular organisms. In animals, the "master clock" is housed in specialized pacemaker neurons in the brain that coordinate various "peripheral clocks" throughout the organism to regulate daily physiological and behavioral changes.

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Managing fuels and fluids: Network integration of osmoregulatory and metabolic hormonal circuits in the polymodal control of homeostasis in insects

Koyama,

Rana,

Halberg

2023

BioEssays

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Osmoregulation in insects is an essential process whereby changes in hemolymph osmotic pressure induce the release of diuretic or antidiuretic hormones to recruit individual osmoregulatory responses in a manner that optimizes overall homeostasis. However, the mechanisms by which different osmoregulatory circuits interact with other homeostatic networks to implement the correct homeostatic program remain largely unexplored. Surprisingly, recent advances in insect genetics have revealed several important metabolic functions are regulated by classic osmoregulatory pathways, suggesting that internal cues related to osmotic and metabolic perturbations are integrated by the same hormonal networks. Here, we review our current knowledge on the network mechanisms that underpin systemic osmoregulation and discuss the remarkable parallels between the hormonal networks that regulate body fluid balance and those involved in energy homeostasis to provide a framework for understanding the polymodal optimization of homeostasis in insects.

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The Ion Transport Peptide Is a New Functional Clock Neuropeptide in the Fruit FlyDrosophila melanogaster

Cited by 96 publications

References 44 publications

Peptidomics of Neuropeptidergic Tissues of the Tsetse FlyGlossina morsitans morsitans

Peptidomics of Neuropeptidergic Tissues of the Tsetse FlyGlossina morsitans morsitans

Coordination between Differentially Regulated Circadian Clocks Generates Rhythmic Behavior

Managing fuels and fluids: Network integration of osmoregulatory and metabolic hormonal circuits in the polymodal control of homeostasis in insects

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