The iodinated radiographic contrast medium iohexol mimics the vasodilator effect seen with small increases in extracellular K⁺ in the isolated rabbit central ear artery

Abstract

The vasodilator effect of IRCM mimics the vasodilator effect seen upon small increase in extracellular K+. Under the experimental conditions employed in the present study, a considerable part of the IRCM-induced vasodilatation appears to be due to activation of Na+/K+-ATPase in the smooth muscle cells.

Incidence of ventricular fibrillation during left coronary arteriography in pigs: comparison of a solution of the nonionic dimer iodixanol with solutions of five different nonionic monomers

“…BØYUM and coworkers (16) have shown convincing evidence that the CM iohexol at plasma iso-osmotic concentration induces an outward K + current over the monocyte cell membrane. Furthermore, the vasodilator effects of CM may be due to vascular smooth muscle hyperpolarization (17). The monomer iopromide is a much more potent vasodilator than the dimer iodixanol (18).…”