The involvement of RIPK4 in TNF-α-stimulated IL-6 and IL-8 production by melanoma cells
Ewelina Madej,
Anna Lisek,
Anna A. Brożyna
et al.
Abstract:Purpose
The receptor-interacting protein kinase (RIPK4) has an oncogenic function in melanoma, regulates NF-κB and Wnt/β-catenin pathways, and is sensitive to the BRAF inhibitors: vemurafenib and dabrafenib which lead to its decreased level. As its role in melanoma remains not fully understood, we examined the effects of its downregulation on the transcriptomic profile of melanoma.
Methods
Applying RNA-seq, we revealed global alterations in the tra… Show more
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