The involvement of neuroinflammation and necroptosis in the hippocampus during vascular dementia

Belkhelfa, Mourad; Beder, Narimene; Mouhoub, Daya; Amri, Manel; Rafa, Hayet; Tighilt, Nabila; Bakheti, Souad; Laimouche, Soraya; Azzouz, Djamel; Belhadj, Rachid; Touil-Boukoffa, Chafia

doi:10.1016/j.jneuroim.2018.04.004

Cited by 65 publications

(50 citation statements)

References 62 publications

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“…At the same time, both CD and UC are associated with high levels of Th17 cytokines that induce the production of TNF-α, IL-1β, and chemokines [10]. Activation of TNF-α, IL-1β, and TGF-β induces necroptosis, whereas neuroinflammation is involved in amyloidogenesis, memory impairment, and multiple sclerosis [11][12][13]. Therefore, DSS-induced colitis serves as a great model to study complex interactions between microbes and the host in a state of inflammation, as well as provides a platform to test molecules capable of modulating microbiome-to-host crosstalk.…”

Section: Introductionmentioning

confidence: 99%

Fucose Ameliorates Tryptophan Metabolism and Behavioral Abnormalities in a Mouse Model of Chronic Colitis

et al. 2020

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Growing evidence suggests that intestinal mucosa homeostasis impacts immunity, metabolism, the Central Nervous System (CNS), and behavior. Here, we investigated the effect of the monosaccharide fucose on inflammation, metabolism, intestinal microbiota, and social behavior in the Dextran Sulfate Sodium (DSS)-induced chronic colitis mouse model. Our data show that chronic colitis is accompanied by the decrease of the serum tryptophan level and the depletion of the intestinal microbiota, specifically tryptophan-producing E. coli and Bifidobacterium. These changes are associated with defects in the male mouse social behavior such as a lack of preference towards female bedding in an odor preference test. The addition of fucose to the test animals' diet altered the bacterial community, increased the abundance of tryptophan-producing E. coli, normalized blood tryptophan levels, and ameliorated social behavior deficits. At the same time, we observed no ameliorating effect of fucose on colon morphology and colitis. Our results suggest a possible mechanism by which intestinal inflammation affects social behavior in male mice. We propose fucose as a promising prebiotic, since it creates a favorable environment for the beneficial bacteria that promote normalization of serum tryptophan level and amelioration of the behavioral abnormalities in the odor preference test.

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Section: Introductionmentioning

confidence: 99%

Fucose Ameliorates Tryptophan Metabolism and Behavioral Abnormalities in a Mouse Model of Chronic Colitis

et al. 2020

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“…Additionally, it was hypothesized that there will be subcortical and deep brain regions exhibiting significant correlations with verb fluency performance. Specifically, we hypothesized that those regions affected early by the effects of dementia such as the hippocampus will be found to correlate with verb fluency performance because the hippocampus is known to contribute to the performance of other verbal fluency tasks (Glikmann-Johnston et al, 2015), and many types of dementias show hippocampal atrophy and dysfunction early in the disease process including FTLD, AD, and vascular dementia (Ostojic et al, 2015;Bede et al, 2018;Belkhelfa et al, 2018;Lladó et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Neural Correlates of Verb Fluency Performance in Cognitively Healthy Older Adults and Individuals With Dementia: A Pilot fMRI Study

Paek

Murray

Newman

2020

Front. Aging Neurosci.

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Currently there are ∼6 million Americans who are affected by dementia. Verbal fluency tasks have been commonly and frequently utilized to document the disease progression in many forms of dementia. Verb fluency has been found to display substantial potential to detect and monitor the cognitive declines of individuals with dementia who have fronto-striatal involvement. The neural substrates underlying verb fluency task performance, however, have remained unclear so far, especially in individuals with dementia. Therefore, in the current study, brain activation patterns of seven individuals with dementia and nine healthy older adults were investigated using functional MRI. The participants performed in the scanner an overt, subject-paced verb fluency task, representative of fluency tasks used in clinical settings. The brain activation patterns during the verb fluency task were compared between the two groups, and a correlational analysis was conducted to determine the neural correlates of verb fluency performance. The results suggest that compared to healthy older adults, individuals with dementia demonstrated poorer verb fluency performance and showed higher activation in specific neural regions, such as the bilateral frontal lobe. In addition, the correlational analysis revealed that poorer verb fluency performance lead to increased activation in certain cortical and subcortical areas, including left hippocampus and right supramarginal gyrus. The current findings are consistent with previous neurophysiological findings related to semantic (noun) fluency performance in older adults and individuals with dementia and add to the empirical evidence that supports the role of the frontal lobe and hippocampus in verb retrieval and search. Declines in verb fluency performance cannot only be used as a cognitive marker, but also represent neuropathological changes due to the neurodegenerative disease.

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“…Beyond parthanatos and mitochondrial permeability transition, other mechanisms involved in neuronal death include intrinsic and extrinsic pathways of the apoptotic process, autophagy, phagoptosis (phagocytosis), oncosis, necroptosis, ferroptosis, sarmoptosis, autosis, autolysis, paraptosis, and pyroptosis . NO has been implicated in all these mechanisms . Figure charts the pathways associated with NO concentration fluctuations.…”

Section: No's Double‐edged Sword: a Cause Of Ocular Pathologymentioning

confidence: 99%

Impact of nitric oxide's bidirectional role on glaucoma: focus on Helicobacter pylori–related nitrosative stress

Papaefthymiou

Doulberis

Katsinelos

et al. 2019

Annals of the New York Academy of Sciences

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Nitric oxide (NO), a small molecule generated ubiquitously, targets a plethora of tissues to regulate both physiological and pathophysiological functions. NO overproduction, stimulated by microenvironmental conditions, is the main component that dysregulates the tight balance between its beneficial and damaging roles in ocular homeostasis. Considering the protective functions of NO against glaucoma, its endogenous release facilitates aqueous humor drainage and regulates ocular blood flow, maintaining a normal intraocular pressure. NO overproduction generates free radicals, such as peroxynitrite, which induce a vicious circle of vascular disharmony and dysregulation, transient ischemia, nitrosative stress, neuronal degeneration, and permanent glaucomatic injury. Helicobacter pylori (Hp) is considered a burdening factor of glaucoma. NO overproduction and possible systematic dispersion in Hp infection (Hp‐I) could suggest a potential pathophysiological bridge between these conditions. In this review, we aim to elucidate the role of NO in glaucoma with respect to Hp‐I, with the aim to stimulate further studies.

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The involvement of neuroinflammation and necroptosis in the hippocampus during vascular dementia

Cited by 65 publications

References 62 publications

Fucose Ameliorates Tryptophan Metabolism and Behavioral Abnormalities in a Mouse Model of Chronic Colitis

Fucose Ameliorates Tryptophan Metabolism and Behavioral Abnormalities in a Mouse Model of Chronic Colitis

Neural Correlates of Verb Fluency Performance in Cognitively Healthy Older Adults and Individuals With Dementia: A Pilot fMRI Study

Impact of nitric oxide's bidirectional role on glaucoma: focus on Helicobacter pylori–related nitrosative stress

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