The involvement of inflammatory cytokines in the pathogenesis of recurrent miscarriage

Giannubilo, Stefano Raffaele; Landi, Beatrice; Pozzi, Valentina; Sartini, Davide; Cecati, Monia; Stortoni, Piergiorgio; Corradetti, Alessandra; Saccucci, Franca; Tranquilli, Andrea Luigi; Emanuelli, Monica

doi:10.1016/j.cyto.2011.12.019

Cited by 53 publications

(37 citation statements)

References 39 publications

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“…We included in this group a variety of inflammatory conditions of the uterus, ovaries, and pelvis as well as Fallopian tubes. These conditions can lead to adhesions or scaring of the Fallopian tubes resulting in difficulties getting pregnant but they can also increase rates of infertility and miscarriage without resulting in scaring (20–22). Given the extent of their influence, a more comprehensive analysis of the prevalence of these inflammatory diagnoses in the infertility population and their effect on outcomes may be warranted.…”

Section: Discussionmentioning

confidence: 99%

Adverse pregnancy and birth outcomes associated with underlying diagnosis with and without assisted reproductive technology treatment

Stern

Luke

Tobias

et al. 2015

Fertility and Sterility

119

116

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Objective To compare the risks for adverse pregnancy and birth outcomes by diagnoses with and without ART treatment to non-ART pregnancies in fertile women. Design Historical cohort Setting Massachusetts vital records linked to ART clinic data from SART CORS Patients Diagnoses included male factor (ART only), endometriosis, ovulation disorders, tubal (ART only) and reproductive inflammatory disorders (non-ART only). Pregnancies resulting in singleton and twin live births from 2004–08 were linked to hospital discharges in women who had ART treatment (N=3,689), women with no ART treatment in the current pregnancy (N=4,098) and non-ART pregnancies to fertile women (N= 297,987). Interventions None Main Outcome Measures Risks of gestational diabetes, prenatal hospitalizations, prematurity, low birth weight, and small-for-gestation were modeled using multivariate logistic regression with fertile deliveries as the reference group adjusted for maternal age, race/ethnicity, education, chronic hypertension, diabetes mellitus, and plurality (adjusted odds ratios, AORs, and 95% confidence intervals, CI). Results Risk of prenatal hospital admissions was increased for endometriosis (ART 1.97, 1.38–2.80; non-ART 3.34, 2.59–4.31), ovulation disorders (ART 2.31, 1.81–2.96; non-ART 2.56, 2.05–3.21), tubal (ART 1.51, 1.14–2.01), and reproductive inflammation (non-ART 2.79, 2.47–3.15). Gestational diabetes was increased for women with ovulation disorders (ART 2.17, 1.72–2.73; non-ART 1.94, 1.52–2.48). Preterm delivery (AORs 1.24–1.93) and low birthweight (AORs 1.27–1.60) were increased in all groups except endometriosis with ART. Conclusions The findings indicate substantial excess perinatal morbidities associated with underlying infertility-related diagnoses in both ART-treated and non-ART-treated women.

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Section: Discussionmentioning

confidence: 99%

Adverse pregnancy and birth outcomes associated with underlying diagnosis with and without assisted reproductive technology treatment

Stern

Luke

Tobias

et al. 2015

Fertility and Sterility

119

116

View full text Add to dashboard Cite

show abstract

“…A number of studies have revealed that the abnormal expression of genes involved in apoptosis, such as Fas/Fas ligand (FasL) (13), transforming growth factor (TGF)-β (14), tumor necrosis factor (TNF)-α (15) and Bcl-2/Bcl-2-associated X protein (Bax) (16), in placental villi and decidual tissues is one of the causes of RSA. p53 is an important protein involved in apoptosis and has been shown to participate in cell cycle regulation (17,18).…”

Section: Discussionmentioning

confidence: 99%

Apoptosis and p53 expression in the placental villi of females with unexplained recurrent spontaneous abortion

Dehua

Shi

2013

Experimental and Therapeutic Medicine

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The aim of this study was to explore the level of apoptosis and p53 expression in the placental villi of patients with unexplained recurrent spontaneous abortion (URSA). Fifty-three pregnant females with URSA and 32 pregnant females who required an induced abortion were selected as the subjects of this study. Placental villus tissues were collected from June 2010 to June 2012 and quantitative polymerase chain reaction (qPCR) and immunohistochemical analysis were performed to determine the mRNA and protein levels of p53 in the placental villus tissues. The level of apoptosis in the tissues was studied using terminal deoxynucleotidyltransferase-mediated dUTP nick end labeling (TUNEL) assay. The mRNA and protein expression levels of p53 in the URSA group were significantly higher than those in the control group (P<0.05). Furthermore, the levels of apoptosis were increased markedly in the URSA group compared with the control group (P<0.05). In conclusion, the placental villi of patients with URSA express a high level of p53, which may result in cell apoptosis and lead to recurrent spontaneous abortion.

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“…Additionally, women with recurrent miscarriages [26] or who experience preterm labor [21] generally fail to down-regulate their Th1 responses particularly at the maternal-fetal interface. They also have improper control of inflammatory cytokine levels at the placental interface [27].…”

Section: Prenatal Symbiosismentioning

confidence: 99%

The Completed Self: An Immunological View of the Human-Microbiome Superorganism and Risk of Chronic Diseases

Dietert

Dietert²

2012

Entropy

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Abstract:In this review, we discuss an immunological-driven sign termed the Completed Self, which is related to a holistic determination of health vs. disease. This sign (human plus commensal microbiota) forms the human superorganism. The worldwide emergence of an epidemic of chronic diseases has caused increased healthcare costs, increased premature mortality and reduced quality of life for a majority of the world's population. In addition, it has raised questions concerning the interactions between humans and their environment and potential imbalances. Misregulated inflammation, a host defensehomeostasis disorder, appears to be a key biomarker connecting a majority of chronic diseases. We consider the apparent contributors to this disorder that promote a web of interlinked comorbid conditions. Three key events are suggested to play a role: (1) altered epigenetic programming (AEP) that may span multiple generations, (2) developmental immunotoxicity (DIT), and (3) failure to adequately incorporate commensal microbes as a newborn (i.e., the incomplete self). We discuss how these three events can combine to determine whether the human superorganism is able to adequately and completely form during early childhood. We also discuss how corruption of this event can affect the risk of later-life diseases.

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The involvement of inflammatory cytokines in the pathogenesis of recurrent miscarriage

Cited by 53 publications

References 39 publications

Adverse pregnancy and birth outcomes associated with underlying diagnosis with and without assisted reproductive technology treatment

Adverse pregnancy and birth outcomes associated with underlying diagnosis with and without assisted reproductive technology treatment

Apoptosis and p53 expression in the placental villi of females with unexplained recurrent spontaneous abortion

The Completed Self: An Immunological View of the Human-Microbiome Superorganism and Risk of Chronic Diseases

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