The involvement of fibroblast growth factor receptor signaling pathways in dermatofibroma and dermatofibrosarcoma protuberans

Ishigami, Tatsuzo; Hida, Yasutoshi; Matsudate, Yoshihiro; Murao, Kazutoshi; Kubo, Yoshiaki

doi:10.2152/jmi.60.106

Cited by 12 publications

(8 citation statements)

References 23 publications

(36 reference statements)

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“…It stimulates the growth and maturation of fibroblasts, in conjunction with other cytokines. It was observed that all the conditions were created for the fibroblasts to have an increased expression in groups with tumors 17 , 23 . In this study, the evaluation of FGF is increased in the groups with tumors, that is, higher than in the control group.…”

Section: Discussionmentioning

confidence: 60%

Growth Factors and Cox2 in Wound Healing: An Experimental Study With Ehrlich Tumors

Salgado

Neto

Filho

2016

ABCD, arq. bras. cir. dig.

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Background: Healing is an innate biological phenomenon, and carcinogenesis acquired, but with common humoral and cellular elements. Carcinogenesis interferes negatively in healing. Aim: To evaluate the histological changes in laparotomy scars of healthy Balb/c mice and with an Ehrlich tumor in its various forms of presentation. Methods: Fifty-four mice were divided into three groups of 18 animals. First group was the control; the second had Ehrlich tumor with ascites; and the third had the subcutaneous form of this tumor. Seven days after tumor inoculation, all 54 mice were submitted to laparotomy. All of the animals in the experiment were operated on again on 7th day after surgery, with resection of the scar and subsequent euthanasia of the animal. The scars were sent for histological assessment using immunohistochemical techniques to evaluate Cox-2 (cyclooxygenase 2), VEGF (vascular endothelial growth factor) and FGF (fibroblast growth factor). Semi-quantitatively analysis was done in the laparotomy scars and in the abdominal walls far away from the site of the operation. Results: Assessing the weight of the animals, the correct inoculation of the tumor and weight gain in the group with tumoral ascites was observed. The histological studies showed that groups with the tumor showed a statistically significant higher presence of Cox-2 compared to the control. In the Cox-2 analysis of the abdominal wall, the ascites group showed the most significant difference. VEGF did not present any significant differences between the three groups, regardless of the site. The FGF showed a significant increase in animals with the tumor. Conclusion: Histological findings in both laparotomy scar and the abdominal wall showed that with Ehrlich's neoplasia there was an exacerbated inflammatory response, translated by more intense expression of Cox-2 and greater fibroblast proliferation, translated by more intense expression of FGF, that is, it stimulated both the immediate inflammatory reactions, observed with Cox-2 reactions, and late scarring by fibroblasts and FGF.

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Section: Discussionmentioning

confidence: 60%

Growth Factors and Cox2 in Wound Healing: An Experimental Study With Ehrlich Tumors

Salgado

Neto

Filho

2016

ABCD, arq. bras. cir. dig.

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“…4 Furthermore, it is known that the expression of FGFR is observed in DFSP although it is not as strong as dermatofibroma. 5 We assume that these are the possible reasons why pazopanib is effective in our case despite no genetic translocations.…”

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confidence: 79%

Pazopanib induced a partial response in a patient with metastatic fibrosarcomatous dermatofibrosarcoma protuberans without genetic translocations resistant to mesna, doxorubicin, ifosfamide and dacarbazine chemotherapy and gemcitabine–docetaxel chemotherapy

Miyagawa

Kadono

Kimura

et al. 2016

The Journal of Dermatology

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Dear Editor, Fibrosarcomatous dermatofibrosarcoma protuberans (FS-DFSP) is a variant of DFSP with increased risk of recurrence and metastasis (~30% and 15%, respectively).1 There are only limited choices of treatment once metastasis occurs. Metastatic DFSP is resistant to conventional chemotherapy. 2Imatinib is effective for metastatic DFSP with genetic translocations involving the platelet-derived growth factor (PDGF) locus. However, it is known that imatinib is not efficacious without the fusion genes, and in such cases there has been almost no promising systemic treatment. We first describe a case of metastatic FS-DFSP without genetic translocations which was resistant to conventional chemotherapy but was sensitive to pazopanib.A 47-year-old man was referred to our department with an abdominal mass (Fig. 1a). Wide local excision was performed. Histopathology revealed that spindle cells were arranged in irregular interwoven fascicles in most parts, while in some parts these cells were lined in diagonal fascicles (Fig. 1b). The tumor cells forming a storiform pattern stained positively for

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“…Overexpression of FOXN1 was observed in the epidermal regions of DFs, suggesting that these regions are similar to SKs both in terms of histological features and the activation of FOXN1. On the other hand, FOXN1 expression was negative to weakly positive in the epidermal regions of DFSPs (65). Thus, DFs and DFSPs, akin to SKs and SCCs, provide another example where FOXN1 expression allows a determination between benign and malignant tumor development.…”

Section: Skin Cancer In Human Patientsmentioning

confidence: 98%

“…In addition, like SKs, the epidermal regions of DFs often display hyperpigmentation. This, again, may be caused by FOXN1 overexpression in epidermal keratinocytes, which promotes melanogenic stimulation in adjacent epidermal melanocytes (65).…”

Section: Skin Cancer In Human Patientsmentioning

confidence: 99%

FOXN1 Transcription Factor in Epithelial Growth and Wound Healing

Grabowska

Wilanowski

2017

Molecular and Cellular Biology

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FOXN1 is a prodifferentiation transcription factor in the skin epithelium. Recently, it has also emerged as an important player in controlling the skin wound healing process, as it actively participates in reepithelialization and is thought to be responsible for scar formation. FOXN1 positivity is also a feature of pigmented keratinocytes, including nevi, and FOXN1 is an attribute of benign epithelial tumors. The lack of FOXN1 favors the skin regeneration process displayed by nude mice, pointing to FOXN1 as a switch between regeneration and reparative processes. The stem cell niche provides a functional source of cells after the loss of tissue following wounding. The involvement of prodifferentiation factors in the regulation of this pool of stem cells is suggested. However, the exact mechanism is still under question, and we speculate that the FOXN1 transcription factor is involved in this process. This review analyzes the pleiotropic effects of FOXN1 in the skin, its function in the tumorigenesis process, and its potential role in depletion of the stem cell niche after injury, as well as its suggested mechanistic role, acting in a cell-autonomous and a non-cell-autonomous manner during skin self-renewal.

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The involvement of fibroblast growth factor receptor signaling pathways in dermatofibroma and dermatofibrosarcoma protuberans

Cited by 12 publications

References 23 publications

Growth Factors and Cox2 in Wound Healing: An Experimental Study With Ehrlich Tumors

Growth Factors and Cox2 in Wound Healing: An Experimental Study With Ehrlich Tumors

Pazopanib induced a partial response in a patient with metastatic fibrosarcomatous dermatofibrosarcoma protuberans without genetic translocations resistant to mesna, doxorubicin, ifosfamide and dacarbazine chemotherapy and gemcitabine–docetaxel chemotherapy

FOXN1 Transcription Factor in Epithelial Growth and Wound Healing

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