The Involvement of Endogenous Neural Oscillations in the Processing of Rhythmic Input: More Than a Regular Repetition of Evoked Neural Responses

Zoefel, Benedikt; Oever, Sanne ten; Sack, Alexander T.

doi:10.3389/fnins.2018.00095

Cited by 149 publications

(177 citation statements)

References 94 publications

(153 reference statements)

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“…Hickok, Farahbod, & Saberi, 2015;Kösem et al, 2018). Similar evidence for an involvement of endogenous oscillatory activity in the field of "entrainment" has been recently summarized elsewhere (Haegens & Zion Golumbic, 2018;Zoefel, ten Oever, & Sack, 2018).…”

Section: Limitations and Future Directionssupporting

confidence: 55%

Perception of rhythmic speech is modulated by focal bilateral tACS

Zoefel¹,

Allard²,

Anil³

et al. 2019

Preprint

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Several recent studies have used transcranial alternating stimulation (tACS) to demonstrate a causal role of neural oscillatory activity in speech processing. In particular, it has been shown that the ability to understand speech in a multi-speaker scenario or background noise depends on the timing of speech presentation relative to simultaneously applied tACS. However, it is possible that tACS did not change actual speech perception but rather auditory stream segregation. In this study, we tested whether the phase relation between tACS and the rhythm of degraded words, presented in silence, modulates word report accuracy. We found strong evidence for a tACS-induced modulation of speech perception, but only if the stimulation was applied bilaterally using ring electrodes (not for unilateral left hemisphere stimulation with square electrodes). These results were only obtained when data was analyzed using a statistical approach that was identified as optimal in a previous simulation study. The effect was driven by a phasic disruption of word report scores. Our results suggest a causal role of neural entrainment for speech perception and emphasize the importance of optimizing stimulation protocols and statistical approaches for brain stimulation research.

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Section: Limitations and Future Directionssupporting

confidence: 55%

Perception of rhythmic speech is modulated by focal bilateral tACS

Zoefel¹,

Allard²,

Anil³

et al. 2019

Preprint

Self Cite

View full text Add to dashboard Cite

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“…Vialatte, Maurice, Dauwels, & Cichocki, 2010). However, the underlying mechanism of SSEPs, is still 57 debated (see Zoefel, Ten Oever, & Sack, 2018). While some studies report evidence for entrainment 58 of ongoing brain oscillations by showing an interaction between stimulation and endogenous activity 59 (Notbohm, Kurths, & Herrmann, 2016;Schwab et al, 2006), others found responses to be nothing 60 more than regular repetitions of evoked neural potentials (Capilla, Pazo-Alvarez, Darriba, Campo, & 61 Gross, 2011; C. Keitel, Quigley, & Ruhnau, 2014).…”

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confidence: 99%

Steady-state responses in the somatosensory system interact with endogenous beta activity

Bächinger

et al. 2019

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Brain oscillations have been related to many aspects of human behavior. To understand a potential causal relationship, it is of great importance to develop methods for modulating ongoing neural activity. It has been shown that external rhythmic stimulation leads to an oscillatory brain response that follows the temporal structure of the presented stimulus and is assumed to reflect the synchronization of ongoing neural oscillations with the stimulation rhythm. This interaction between individual brain activity and so called steady-state evoked potentials (SSEPs) is the fundamental requirement of neural entrainment. Here, we investigate whether neural responses to rhythmic vibrotactile stimulation, measured with EEG, are dependent on ongoing individual brain oscillations, and therefore reflect entrained oscillatory activity. For this, we measured phase synchronization in response to rhythmic stimulation across various frequencies in the alpha and beta band. Three different stimulation intensities were applied for each frequency relative to the individual sensory threshold. We found that a higher stimulation intensity, compared to lower intensities, resulted in a more pronounced phase synchronization with the stimulation signal. Moreover, EEG responses to low stimulation frequencies closer to individual beta peak frequencies revealed a higher degree of entrainment, compared to stimulation conditions with frequencies that were more distant to endogenous oscillations. Our findings provide evidence that the efficacy of vibrotactile rhythmic beta stimulation to evoke a SSEPs is dependent on ongoing brain oscillations.

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“…The effects of tACS on auditory perception are thought to be mediated by oscillatory neural mechanisms that would be critical for auditory and linguistic processing (Giraud and Poeppel 2012;Peelle and Davis 2012;Zoefel, ten Oever, and Sack 2018). Previous evidence shows that neural activity in the auditory cortices tracks the rhythmic structure of the speech signal.…”

Section: Introductionmentioning

confidence: 99%

Biasing the perception of spoken words with tACS

Kösem

Bosker

Jensen

et al. 2019

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Recent neuroimaging evidence suggests that the frequency of entrained oscillations in auditory cortices influences the perceived duration of speech segments, impacting word perception (Kösem et al. 2018). We further tested the causal influence of neural entrainment frequency during speech processing, by manipulating entrainment with continuous transcranial alternating current stimulation (tACS) at distinct oscillatory frequencies (3 Hz and 5.5 Hz) above the auditory cortices. Dutch participants listened to speech and were asked to report their percept of a target Dutch word, which contained a vowel with an ambiguous duration. Target words were presented either in isolation (first experiment) or at the end of spoken sentences (second experiment). We predicted that the frequency of the tACS current would influence neural entrainment and therewith how speech is perceptually sampled, leading to a perceptual over-or underestimation of the vowel duration. Experiment 1 revealed no significant result. In contrast, results from experiment 2 showed a significant effect of tACS frequency on target word perception. Faster tACS lead to more long-vowel word percepts, in line with previous findings suggesting that neural oscillations are instrumental in the temporal processing of speech. The different results from the two experiments suggest that the impact of tACS is dependent on the sensory context. tACS may have a stronger effect on spoken word perception when the words are presented in a continuous stream of speech as compared to when they are isolated, potentially because prior (stimulus-induced) entrainment of brain oscillations might be a prerequisite for tACS to be effective.

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The Involvement of Endogenous Neural Oscillations in the Processing of Rhythmic Input: More Than a Regular Repetition of Evoked Neural Responses

Cited by 149 publications

References 94 publications

Perception of rhythmic speech is modulated by focal bilateral tACS

Perception of rhythmic speech is modulated by focal bilateral tACS

Steady-state responses in the somatosensory system interact with endogenous beta activity

Biasing the perception of spoken words with tACS

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