The involvement of annexin A1 in human placental response to maternal Zika virus infection

Targeting the Annexin A1-FPR2/ALX pathway for host-directed therapy in dengue disease

“…In line with this, a growing body of evidence indicates that pro-resolving mediators are regulated during infection , contributing to the control and resolution of experimental and human infectious diseases ( Abdulnour et al, 2016 ; Basil and Levy, 2016 ; Chiang et al, 2012 ; Frediani et al, 2014 ; Oliveira et al, 2017 ; Shirey et al, 2014 ). On the other hand, dysregulation in the production and/or action of pro-resolving mediators might contribute to the pathogenesis of sterile ( Eke Gungor et al, 2014 ; Fredman et al, 2016 ; Murri et al, 2013 ; Sena et al, 2013 ; Thul et al, 2017 ; Vong et al, 2012 ) and infectious ( Cilloniz et al, 2010 ; Colas et al, 2019 ; Molás et al, 2020 ; Morita et al, 2013 ) diseases, including atherosclerosis, inflammatory bowel diseases and tuberculous meningitis. Modulation of AnxA1 in the context of viral infections has been less investigated, and clinical data are scarce ( Arora et al, 2016 ; Molás et al, 2020 ).…”

“…On the other hand, dysregulation in the production and/or action of pro-resolving mediators might contribute to the pathogenesis of sterile ( Eke Gungor et al, 2014 ; Fredman et al, 2016 ; Murri et al, 2013 ; Sena et al, 2013 ; Thul et al, 2017 ; Vong et al, 2012 ) and infectious ( Cilloniz et al, 2010 ; Colas et al, 2019 ; Molás et al, 2020 ; Morita et al, 2013 ) diseases, including atherosclerosis, inflammatory bowel diseases and tuberculous meningitis. Modulation of AnxA1 in the context of viral infections has been less investigated, and clinical data are scarce ( Arora et al, 2016 ; Molás et al, 2020 ). Since recent evidence suggests a defective engagement of pro-resolving pathways during self-resolving infections ( Cilloniz et al, 2010 ; Colas et al, 2019 ; Molás et al, 2020 ; Morita et al, 2013 ), we queried whether such alterations could also be occurring in dengue disease.…”

“…Modulation of AnxA1 in the context of viral infections has been less investigated, and clinical data are scarce ( Arora et al, 2016 ; Molás et al, 2020 ). Since recent evidence suggests a defective engagement of pro-resolving pathways during self-resolving infections ( Cilloniz et al, 2010 ; Colas et al, 2019 ; Molás et al, 2020 ; Morita et al, 2013 ), we queried whether such alterations could also be occurring in dengue disease. Focus was given to the pro-resolving protein AnxA1 and its cognate receptor FPR2/ALX, a pathway that has been shown to exert a degree of protection in experimental tuberculosis ( Tzelepis et al, 2015 ; Vanessa et al, 2015 ), sepsis ( Damazo et al, 2005 ; Gobbetti et al, 2014 ), pneumococcal pneumonia ( Machado et al, 2020 ; Tavares et al, 2016 ), and influenza ( Schloer et al, 2019 ).…”

ANNEXIN A1: Roles in Placenta, Cell Survival, and Nucleus

“…Our research group identified that ANXA1 is highly expressed in the placenta, especially in the syncytiotrophoblast, while there is a decrease in the gene expression of this protein in groups infected with ZIKV [53]. These data suggest that maternal infection with ZIKV is sufficient to develop an inflammatory response in the placenta by increasing the recruitment of cytokines and inflammatory cells, possibly related to ANXA1 modulation.…”

“…Recent studies have investigated ANXA1 in different models of inflammation [13,[48][49][50][51], including placentas from high-risk pregnancies, such as those associated with Toxoplasma gondii [52] and Zika virus (ZIKV) infections [53] (Figure 1).…”